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Cirrhosis Research Studies

Cirrhosis is a condition in which the liver slowly deteriorates and is unable to function normally due to chronic, or long lasting, injury. Scar tissue replaces healthy liver tissue and partially blocks the flow of blood through the liver.

Investigators

Naga P. Chalasani, MD

Interim Chair, Department of Medicine

Archita Desai, MD

Assistant Professor of Medicine

Marwan S. Ghabril, MD

Professor of Medicine

Craig Lammert, MD

Assistant Professor of Medicine

Eric Orman, MD

Assistant Professor of Medicine

Kavish Patidar, DO, BS

Assistant Professor of Medicine

Raj Vuppalanchi, MB,BS

Professor of Medicine

Open Research Studies for Cirrhosis

ALC Database

Enrolling: Yes

Principle Investigator: Craig Lammert, MD

Duration: 1 visit

Patient Population: Alcoholic liver cirrhosis, no viral hepatitis, pre/post transplant.

Interested in this study? Please contact the following coordinator:
Kelsey Green
greenke@iu.edu
(317) 278-9292

The Cirrhosis Medical Home

Enrolling: Yes

Principle Investigator: Eric Orman, MD

Duration: Patients are enrolled for 6 months - total study duration is 2 years.

Patient Population: Patients with cirrhosis who have recently been discharged from the hospital and their caregivers.

Interested in this study? Please contact the following coordinator:
Elizabeth Peek
peeke@iu.edu
(317) 278-9303

Cirrhosis OP QoL

Enrolling: Yes

Principle Investigator: Archita Desai, MD

Duration: 3 -5 years

Patient Population: Patients over the age of 18 with cirrhosis.

Interested in this study? Please contact the following coordinator:
Logan Hobbs
lshobbs@iu.edu
(317) 274-8422

Cirrhosis Readmit. Inpatient

Enrolling: Yes

Principle Investigator: Archita Desai, MD

Duration: 3 - 5 years

Patient Population: Inpatients over the age of 18 with cirrhosis.

Interested in this study? Please contact the following coordinator:
Logan Hobbs
lshobbs@iu.edu
(317) 274-8422

Galectin - Phase 2b/3

Enrolling: TBD

Principle Investigator: Raj Vuppalanchi, MD

Duration: 52 week treatment period with possibility of 52 additional weeks.

Patient Population: Patients 18-75 years old with NASH cirrhosis and no varices.

Drug(s): Belapectin every 2 week infusion.

Interested in this study? Please contact the coordinator below:
Mandy Cruz
mandcruz@iu.edu
(317) 278-6215

HRQoL Comparison

Enrolling: Yes

Principle Investigator: Naga Chalasani, MD

Duration: 3 - 5 years

Patient Population: Patients that are over 18 years old with liver disease.

Interested in this study? Please contact the following coordinator:
Logan Hobbs
lshobbs@iu.edu
(317) 274-8422

ICU Study

Enrolling: Yes

Principle Investigator: Kavish Patidar, DO

Duration: 5 years

Patient Population: Adults over the age of 18 with a diagnosis of cirrhosis admitted to the ICU.

Interested in this study? Please contact the following coordinator:
Casey Snoddy
casnoddy@iu.edu
(317) 278-8118

Midwest Cirrhosis Consortium

Enrolling: Yes

Principle Investigators: Marwan Ghabril, MD and Eric Orman, MD

Duration: 1 visit

Patient Population: Adults over the age of 18 with a diagnosis of cirrhosis admitted to the ICU, PCU and wards as an inpatient.

Inerested in this study? Please contact the following coordinator:
Jake McCarty
jacmccar@iu.edu
(317) 278-6305

Safety and Efficacy of Ketogenic Diet for PromotingWeight Loss in Obese Individuals with Compensated NASH Cirrhosis

Enrolling: Yes

Principle Investigator: Raj Vuppalanchi, MD

Duration: 16 weeks

Patient Population: Patients over the age of 18 with a diagnosis of NASH cirrhosis with a BMI >30kg/m2.

Interested in this study? Please contact the following coordinator:
Casey Snoddy
casnoddy@iu.edu
(317) 278-8118

Tocotrienol

Enrolling: Yes

Principle Investigator: Raj Vuppalanchi, MD

Duration: 3 years

Patient Population: Compensated or decompensated with only 1 symptom of decompensation of NASH cirrhosis with MELD score 10-15.

Drug(s): Tocovid/tocotrienol

Interested in this study? Please contact the coordinator below:
Heather Adams
hadams3@IUHealth.org
(317) 962-1130

Closed Cirrhosis Studies

  • Cirrhotic Database

    Enrolling: No

    Duration: 1 visit.

  • UCD Database

    Enrolling: No

    Duration: 1 visit.