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Indiana University School of Medicine
Studies

Cirrhosis Research Studies

Cirrhosis is a condition in which the liver slowly deteriorates and is unable to function normally due to chronic, or long lasting, injury. Scar tissue replaces healthy liver tissue and partially blocks the flow of blood through the liver.

Investigators

4910-Chalasani, Naga

Naga P. Chalasani, MD

David W. Crabb Professor of Gastroenterology and Hepatology

42036-Desai, Archita

Archita Desai, MD

Assistant Professor of Medicine

5104-Ghabril, Marwan

Marwan S. Ghabril, MD

Professor of Medicine

4796-Lammert, Craig

Craig Lammert, MD

Assistant Professor of Medicine

5166-Orman, Eric

Eric Orman, MD

Associate Professor of Medicine

5034-Vuppalanchi, Raj

Raj Vuppalanchi, MD

Professor of Medicine

Open Research Studies for Cirrhosis

A Study for Evaluation of BIV201 to Reduce Ascites and Complications in Patients With Cirrhosis and Refractory Ascites

Enrolling: No

Principle Investigator: Eric Orman, MD

Duration: 1 year

Patient Population: Patients with refractory ascites

Drug(s): Terlipressin

Interested in this study? Please contact the following coordinator:

Holly King

hrking1@iu.edu

(317) 278-6200

View the study on clinicaltrials.gov

ALTUS: Performance of a Multi-Target Hepatocellular Carcinoma (HCC) Test in Subjects with Increased Risk

Enrolling: No

Principle Investigator: Naga Chalasani, MD

Duration: 6-8 months

Patient Population: Adults 18+, Child-Pugh A or B, no known cancer diagnosis < 5 years

Interested in this study? Please contact the following coordinator:
Jake McCarty
jacmccar@iu.edu
(317) 278-6305

The Cirrhosis Medical Home

Enrolling: No

Principle Investigator: Eric Orman, MD

Duration: Patients are enrolled for 6 months - total study duration is 2 years.

Patient Population: Patients with cirrhosis who have recently been discharged from the hospital and their caregivers.

Interested in this study? Please contact the following coordinator:

Jake McCarty

jacmccar@iu.edu

(317) 278-6305

 

Kristin Struck

krstruck@iu.edu

(317) 278-6206

A Randomized, Double-Blind, Placebo-Controlled, Multicenter Study to Assess the Efficacy and Safety of Rifaximin Soluble Solid Dispersion (SSD) Tablets for the Delay of Encephalopathy Decompensation in Cirrhosis (RED-C) RNLC3131 and RNLC3132

Enrolling: No

Principle Investigator: Marwan Ghabril, MD

Duration: 72 week treatment period with 4 week screening and 4 week follow-up

Patient Population: Adults with cirrhosis and no history of hepatic encephalopathy

Drug(s): Rifaximin SSD/placebo

Interested in this study? Please contact the coordinator below:

Jennifer Terrell

jkramey@iu.edu

(317) 278-6266

View the study on clinicaltrials.gov

Galectin - Phase 2b/3

Enrolling: No

Principle Investigator: Raj Vuppalanchi, MD

Duration: 52 week treatment period with possibility of 52 additional weeks.

Patient Population: Patients 18-75 years old with NASH cirrhosis and no varices.

Drug(s): Belapectin every 2 week infusion.

Interested in this study? Please contact the coordinator below:
Mandy Cruz
mandcruz@iu.edu
(317) 278-6215

Midwest Cirrhosis Consortium

Enrolling: Yes

Principle Investigators: Marwan Ghabril, MD and Eric Orman, MD

Duration: 1 visit

Patient Population: Adults over the age of 18 with a diagnosis of cirrhosis admitted to the ICU, PCU and wards as an inpatient.

Interested in this study? Please contact the following coordinator(s):
Jake McCarty
jacmccar@iu.edu
(317) 278-6305

Janeth Castano
jccastan@iu.edu
(317) 278-2401

Safety and Efficacy of Ketogenic Diet for PromotingWeight Loss in Obese Individuals with Compensated NASH Cirrhosis

Enrolling: Yes

Principle Investigator: Raj Vuppalanchi, MD

Duration: 16 weeks

Patient Population: Patients over the age of 18 with a diagnosis of NASH cirrhosis with a BMI >30kg/m2.

Interested in this study? Please contact the following coordinator:
Emily Smith
es37@iu.edu
(317) 274-1692

Tocotrienol

Enrolling: Yes

Principle Investigator: Kavish Patidar, DO

Duration: 5 years

Patient Population: Adults over the age 18 with a diagnosis of cirrhosis admitted to the ICU.

Interested in this study? Please contact the following coordinator:

Anna Smith

asmith81@IUHealth.org

(317) 962 - 9978

View the study on clinicaltrials.gov

Closed Cirrhosis Studies

  • ALC Database

    Enrolling: No

    Principle Investigator: Craig Lammert, MD

    Duration: 1 visit

    Patient Population: Alcoholic liver cirrhosis, no viral hepatitis, pre/post-transplant

  • Cirrhosis Readmit. Inpatient

    Enrolling: No

    Principle Investigator: Archita Desai, MD

    Duration: 3-5 years

    Patient Population: Inpatients over the age of 18 with cirrhosis.

  • A Phase 2, Multicenter, Randomized, Double-Blind, Placebo-Controlled Trial to Evaluate the Efficacy and Safety of AXA1665 in Subjects With Liver Cirrhosis and Prior Overt Hepatic Encephalopathy (EMMPOWER)
    Enrolling: No Principle Investigator: Marwan Ghabril, MD

    Duration: 24 week treatment period with 4 week screening and 4 week follow-up

    Patient Population: Adults with cirrhosis and history of hepatic encephalopathy

    Drug(s): AXA1665/Placebo

    View this study on clinicaltrials.gov

  • ICU Study

    Enrolling: No

    Principle Investigator: Kavish Patidar, DO

    Duration: 5 years

    Patient Population: Adults over the age of 18 with a diagnosis of cirrhosis admitted to the ICU.

  • Orman Fitness Pilot Study
    Enrolling: No

    Principle Investigator: Eric Orman, MD

    Duration: 3 months

    Patient Population: 18 and older

  • Cirrhotic Database

    Enrolling: No

    Duration: 1 visit.

  • UCD Database

    Enrolling: No

    Duration: 1 visit.

  • HRQoL Comparison Study

    Enrolling: No

    Principle Investigator: Naga Chalasani, MD

    Duration: 3 - 5 years

    Patient Population: Patients that are over 18 years old with liver disease

  • Cirrhosis OP QoL
    Enrolling: No

    Principle Investigator: Archita Desai, MD

    Duration: 3 -5 years

    Patient Population: Patients over the age of 18 with cirrhosis.