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Physician-scientists at IU School of Medicine conduct ground-breaking research studies to understand gastroparesis.

Gastroparesis Research Studies

Gastroparesis, or paralysis of the stomach, refers to a stomach that empties slowly. Gastroparesis is characterized by symptoms by bloating, nausea, vomiting and feeling full after eating only a small amount of food. Some patients can be quite sick with nausea, retching, vomiting and weight loss requiring ER visits and hospitalizations. Gastroparesis can occur as a result of several conditions, especially in people with diabetes. However, the cause of gastroparesis is not known in many patients. It is more common in women than men.

Investigators

4915-Nowak, Thomas

Thomas V. Nowak, MD

Professor of Clinical Medicine

Read Bio Thomas V. Nowak, MD

5155-Siwiec, Robert

Robert M. Siwiec, MS, MD

Associate Professor of Clinical Medicine

Read Bio Robert M. Siwiec, MS, MD

5144-Wo, John

John M. Wo, MD

Douglas Rex Professor of Gastroenterology and Hepatology

Read Bio John M. Wo, MD

Open Research Studies for Gastroparesis

Magnetic Resonance Imaging of the Brain and the Upper Gastrointestinal Tract in Healthy Volunteers and Patients with Gastroparesis

Enrolling: Yes

Principle Investigator: John M. Wo, MD

Primary Outcomes Measured: Compare 3D--dimensional gastric peristalsis progression before & after test meals in healthy volunteers and patients with gastroparesis

Secondary Outcomes Measured:

  1. Compare colored 3-D heat map of stomach contraction frequency before & after test meals in healthy volunteers and patients with gastroparesis
  2. Compare pylorus mean opening diameter before & after test meals in healthy volunteers and patients with gastroparesis 

 

Gastroparesis Test Meal ImageImage related to Gastroparesis - showing internal organsImage featuring Antral Peristalsis

 

Interested in this study? Please contact the coordinator below:

Kara Murphy
clarkara@iu.edu

Anita Gupta
anigupta@iu.edu

View the study on clinicaltrials.gov

Effect of Electrical Stimulation of the Auricular Branch of the Vagus Nerve (ABVN) on Cervical Vagus Nerve Compound Action Potentials- Phase 2

Enrolling: Yes

Principle Investigator: Thomas V. Nowak, MD

Duration: TBD

Primary Outcomes Measured: To measure the amplitude of vagal nerve compound action potentials in gastroparetic subjects with symptoms of nausea and vomiting with skin electrodes over right and left vagus nerve during ABVN stimulation and also during the vagal maneuvers phase.

Secondary Outcomes Measured: To measure changes in the amplitude of the surface electrogastrogram during ABVN and also during the vagal maneuvers phase.

Interested in this study? Please contact the coordinator below

Anita Gupta

(317) 278-0406
anitgupta@iu.edu