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Eosinophilic GI Disorders Research Studies

Eosinophilic esophagitis (EoE) is a chronic, allergic inflammatory disease of the esophagus. EoE affects children and adults. It occurs when a type of white blood cell, the eosinophil, accumulates in the esophagus. The elevated number of eosinophils causes injury and inflammation to the esophagus. Eventually leading to scar tissues. Adults with EoE usually present with difficulty swallowing. Many patient have other allergic diseases, such as seasonal allergies, asthma, allergic reactions to foods and environment.


4878-Kessler, William

William R. Kessler, MD

Associate Professor of Clinical Medicine

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5155-Siwiec, Robert

Robert M. Siwiec, MD

Assistant Professor of Clinical Medicine

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5144-Wo, John

John M. Wo, MD

Douglas Rex Professor of Gastroenterology and Hepatology

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Open Research Studies for Eosinophilic Eosophagitis

Changes in Esophageal Distensability in Patients with Esophageal Eosinophilia with Proton Pump Inhibitors and Patients with Eosinophilic Esophagitis with Steroid Suspension

Enrolling: Yes
Principle Investigator: John M. Wo, MD
Duration: 4 months
Primary Outcomes Measured: Change in proximal and distal esophageal distensibility before and after treatment
Interested in this study? Please contact the coordinator below:
Megan Rattin
(317) 278-0695

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Study to Determine the Efficacy and Safety of Dupilumab in Adult and Adolescent Patients with Eosinophilic Esophagitis

Enrolling: Yes
Principle Investigator:John M. Wo, MD

Duration: 24 weeks
Primary Outcomes Measured:

  1. Proportion of patients achieving peak esophageal intraepithelial eosinophil count of ≤6 eosinophils per high-power field Absolute change in Dysphagia Symptom Questionnaire score
  2. Frequency and intensity of dysphagia.

Interested in this study? Please contact the coordinator below:
Alka Kadariya

(317) 278-9296

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