Diseases of the Pancreas Research Studies

Enrolling: Yes

Principle Investigator: Evan Fogel, MD

Primary Outcomes Measured:  Reduce the risk of subsequent acute pancreatitis episodes by 33%.

Enrolling: Yes

Principle Investigator: Evan Fogel, MD

Primary Objectives:

1. To establish a model longitudinal research cohort of adult patients for the study of chronic pancreatitis and its complications.
2. To estimate the risk of progression from suspected to definite chronic pancreatitis, and the risk of new-onset diabetes or exocrine insufficiency in definite chronic pancreatitis, and how the risks are influenced by patient characteristics and conditions.
3. To test the predictive capability of candidate biomarkers for diagnosis and prognosis of chronic pancreatitis.
4. To develop a framework for conducting biomarker, genetic, and mechanistic studies using clinical information and the biorepository developed as part of the longitudinal research cohort.

Enrolling: Yes

Principle Investigator: Jeffrey Easler, MD

Primary Objective:  Distinguish phenotypes characterized by segmental sensitization of the pancreatic viscerotome, and systematic sensitization with pathological central pain processing including augmented temporal summation and impaired descending pain inhibition.

Enrolling: Yes

Principle Investigator: Jeffrey Easler, MD

Primary Objective: Obtain pilot data to determine the optimal method of clearing large main pancreatic duct stones.

Enrolling: Yes

Principle Investigator:  Zeb Saeed, MD

Primary Objectives: 

1. Evaluate the pancreatic polypeptide response following a standardized mixed meal in new onset diabetes associated with PDAC and chronic pancreatitis vs. T2DM.

2. Evaluate the insulin and glucagon response following a standardized mixed meal in new onset diabetes associated with PDAC and chronic pancreatitis vs. T2DM.

3. Evaluate the incretin response following a standardized mixed meal in new onset diabetes associated with PDAC and chronic pancreatitis vs. T2DM.

4. Explore the differences in analytes from Objectives 1-3 in a cohort of subjects with the same diseases and long-standing DM or normoglycemia.

Enrolling: Yes

Principle Investigator: John DeWitt, MD

Primary Objective: Evaluate the efficacy and safety of chemotherapeutic pancreatic cyst ablation using ethanol lavage followed by the infusion of a dual-agent chemotherapeutic cocktail (paclitaxel + gemcitabine) compared with alcohol-free saline lavage followed by infusion of the same dual-agent chemotherapeutic cocktail (paclitaxel + gemcitabine) for the ablation of pancreatic cystic neoplasms using endoscopic ultrasound guided fine needle infusion (EUS-FNI) for agent delivery.

Enrolling: Yes

Principal Investigator: Mohammad Al-Haddad, MD

Primary Objective: Establish a biorepository to store leftover human specimens for use in the research and development and validation of diagnostic products.

Enrolling: Yes

Principal Investigator: Mohammad Al-Haddad, MD

Primary Objective: Collecting data related to endoscopic ultrasound procedures performed by Indiana University EUS physicians; specifically for the management of chronic pancreatitis pain. This data will be used for research purposes to determine the clinical impact of EUS-CPN management in chronic pancreatitis pain. The physicians will also be able to better understand the patient's condition and disease process that may lead to improved patient management.

Enrolling: Yes

Principle Investigator: Evan Fogel, MD

Primary Objective: Conduct a prospective longitudinal (36 months) observational clinical study to investigate the incidence, etiology, and pathophysiology of diabetes mellitus (DM) following acute pancreatitis (AP).