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Primary Biliary Cholangitis

Primary biliary cholangitis (PBC), previously called primary biliary cirrhosis, is a chronic disease in which the bile ducts in the liver are slowly destroyed.

Investigators

4796-Lammert, Craig

Craig Lammert, MD

Assistant Professor of Medicine

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5034-Vuppalanchi, Raj

Raj Vuppalanchi, MB,BS

Professor of Medicine

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Open Research Studies for Primary Biliary Cholangitis

Cara PBC

Enrolling: Yes

Principle Investigator: Raj Vuppalanchi, MD

Duration: 21 weeks

Patient Population: Patients with moderate to severe itching.

Drug(s): Oral CR845

Interested in this study? Please contact the coordinator below:
Mandy Cruz
mandcruz@iu.edu
(317) 278-6215

Intercept - 302 PBC

Enrolling: Yes

Principle Investigator: Raj Vuppalanchi, MD

Duration: Upwards 6 - 8 years.

Patient Population: PBC with total Bili > ULN and ≤3x ULN or ALP >5x ULN

Drug(s): Obeticholic Acid tablet or placebo

Interested in this study? Please contact the coordinator below:
Holly King
hrking1@iu.edu
(317) 278-6200

PBC Itch

Enrolling: Yes

Principle Investigator: Craig Lammert, MD

Duration: 1 visit

Patient Population: PBC/Pre-Transplant and history of no/minimal itch or severe itch.

Interested in this study? Please contact the coordinator below:
Kelsey Green
greenke@iu.edu
(317) 278-9292

Zydus PBC

Enrolling: Yes

Principle Investigator: Raj Vuppalanchi, MD

Duration: 26 weeks

Patient Population: Non-cirrhotic

Drug(s): Oral Saroglitazar

Interested in this study? Please contact the coordinator below:
Mandy Cruz
mandcruz@iu.edu
(317) 278-6215

Phase 1 Zydus Discovery SARO.19.003

Enrolling: TBD

Principle Investigator: Raj Vuppalanchi, MD

Duration: 44 day study period

Patient Population: Patients 18-80 years old with either a diagnosis of PBC or PSC.

Drug(s): Single oral dose Saroglitazar Magnesium

Interested in this study? Please contact the coordinator below:
Mandy Cruz
mandcruz@iu.edu
(317) 278-6215