Skip to main content

Crohn's Disease Research Studies

Crohn's disease is a type of inflammatory bowel disease (IBD). It causes inflammation of the digestive tract, which can lead to abdominal pain, severe diarrhea, fatigue, weight loss and malnutrition. Inflammation caused by Crohn's disease can involve different areas of the digestive tract in different people.

Investigators

5139-Bohm, Matthew

Matthew Bohm, BA, DO

Assistant Professor of Clinical Medicine

Read Bio

4964-Fischer, Monika

Monika Fischer, MD

Associate Professor of Medicine

Read Bio

5125-Sagi, Sashi

Sashi Sagi, MD

Associate Professor of Clinical Medicine

Read Bio

Open Research Studies for Crohn's Disease

Diversity

Enrolling: Yes

Principle Investigator: Matthew Bohm, MD

Duration: 32-66 weeks + Long-term Extension (Approx. 8-13 clinic visits)

Patient Population:  Adult patients with moderately to severely active Crohn’s disease

Study Intervention:  Filgotinib (Oral)

Possibility of Placebo:  1 in 3

Interested in this study? Please contact the coordinator below:

Tonika Peterson

tonipete@iu.edu

(317) 948-3369

Galaxi

Enrolling: Yes

Principle Investigator: Sashidhar Sagi, MD

Duration: 48 weeks + potential to receive up to 2 additional years of treatment

Patient Population: Adult patients with moderately to severely active Crohn’s disease

Study Intervention:  Guselkumab or Ustekinumab  ( IV + Subcutaneous)

Possibility of Placebo:  1 in 5

Tonika Peterson

tonipete@iu.edu

(317) 948-3369

Yellowstone

Enrolling: Yes

Principle Investigator:  Monika Fischer, MD

Duration: 12 Weeks + potential to receive treatment for up to 4.5 years

Patient Population: Adult patients with moderately to severely active Crohn’s disease

Study Intervention:  Ozanimod (Oral)

Possibility of Placebo: 1 in 3

Interested in this study? Please contact the coordinator below:

Neeley Dukles

ndukles@iu.edu

(317) 278-9238

SPARC IBD

Enrolling: Yes

Principle Investigator:  Matthew Bohm, DO

Duration:  All bio-specimen collections and chart reviews will continue until 2026

Patient Population: Any patient with either Crohn’s Disease or Ulcerative Colitis

Study Intervention:  Medical chart reviews and biological specimen collection.

Interested in this study? Please contact the coordinator below:

Bianca Burrell

burrellb@iu.edu

(317) 278-0609

VIVID - 1

Enrolling: Yes

Principle Investigator:  Monika Fischer, MD

Duration: 1 year – Option to roll into the long term extension study VIVID-2

Patient Population: Adult patients with moderately to severely active Crohn’s disease

Study Intervention:  Mirikizumab vs Stelara vs Placebo

Possibility of Placebo: 2 in 11

Interested in this study? Please contact the coordinator below:

Tonika Peterson

tonipete@iu.edu

(317) 948-3369

IBD QORUS

Enrolling: Yes

Principle Investigator:  Sashidhar Sagi, MD

Duration:  Indefinate or upon withdraw

Patient Population: Any patient with either Crohn’s Disease or Ulcerative Colitis

Study Procedures:  Patient surveys before every office visit & medical chart reviews

Interested in this study? Please contact the coordinator below:

Neeley Dukles

ndukles@iu.edu

(317) 278-9238

Lattice

Enrolling: Yes

Principle Investigator:  Monika Fischer, MD

Duration: Approximately 112 weeks

Patient Population: Adult patients with moderately to severely active Crohn’s disease

Study Intervention:  BMS-986165 (oral)

Possibility of Placebo: 1 in 4

Interested in this study? Please contact the coordinator below:

Debbie Drenzyk

robinsd@iu.edu

(317) 948-9212