Primary Sclerosing Cholangitis

Primary sclerosing cholangitis (PSC) is a condition that affects the bile ducts. These ducts carry bile from the liver, where bile is produced, to the gallbladder, where it is stored, and to the small intestine, where it aids in digestion. Primary sclerosing cholangitis occurs because of inflammation in the bile ducts (cholangitis) that leads to scarring (sclerosis) and narrowing of the ducts. As a result, bile cannot be released to the gallbladder and small intestine, and it builds up in the liver.

Enrolling: Yes

Principle Investigator: Raj Vuppalanchi, MD

Duration: P3 - 110 weeks

Patient Population: Non-cirrhotic large duct PSC

Drug(s): Oral GS9674 (Cilofexor)

Interested in this study? Please contact the coordinator below:
Mandy Cruz
mandcruz@iu.edu
(317) 278-6215

Enrolling: Yes

Principle Investigator: Craig Lammert, MD

Duration: 1 visit

Patient Population: PSC with at least 6 month biochemical presence of chronic cholangitis, must not have NASH.

Interested in this study? Please contact the coordinator below:
Kelsey Green
greenke@iu.edu
(317) 278-9292

Enrolling: Yes

Principle Investigator: Raj Vuppalanchi, MD

Duration: 12 week study period

Patient Population: PSC patients without cirrhosis.

Drug(s): PLN-74809 Oral

Interested in this study? Please contact the coordinator below:

Mandy Cruz
mandcruz@iu.edu
(317) 278-6215

Enrolling: Yes

Principle Investigator: Craig Lammert, MD

Duration: 1 visit.

Patient Population: Patients with PSC with ERCP, MRCP or liver biopsy.

Interested in this study? Please contact the coordinator below:
Kelsey Green
greenke@iu.edu
(317) 278-9292