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Primary Sclerosing Cholangitis

Primary sclerosing cholangitis (PSC) is a condition that affects the bile ducts. These ducts carry bile from the liver, where bile is produced, to the gallbladder, where it is stored, and to the small intestine, where it aids in digestion. Primary sclerosing cholangitis occurs because of inflammation in the bile ducts (cholangitis) that leads to scarring (sclerosis) and narrowing of the ducts. As a result, bile cannot be released to the gallbladder and small intestine, and it builds up in the liver.

Investigators

4796-Lammert, Craig

Craig Lammert, MD

Assistant Professor of Medicine

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5034-Vuppalanchi, Raj

Raj Vuppalanchi, MB,BS

Professor of Medicine

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Open Research Studies for Primary Sclerosing Cholangitis

Gilead PSC (P2 & P3)


Enrolling:
 Yes

Principle Investigator: Raj Vuppalanchi, MD

Duration: P3 - 110 weeks

Patient Population: Non-cirrhotic large duct PSC

Drug(s): Oral GS9674 (Cilofexor)

Interested in this study? Please contact the coordinator below:
Mandy Cruz
mandcruz@iu.edu
(317) 278-6215

Mayo RC2

Enrolling: Yes

Principle Investigator: Craig Lammert, MD

Duration: 1 visit

Patient Population: PSC with at least 6 month biochemical presence of chronic cholangitis, must not have NASH.

Interested in this study? Please contact the coordinator below:
Kelsey Green
greenke@iu.edu
(317) 278-9292

Pliant

Enrolling: Yes

Principle Investigator: Raj Vuppalanchi, MD

Duration: 12 week study period

Patient Population: PSC patients without cirrhosis.

Drug(s): PLN-74809 Oral

Interested in this study? Please contact the coordinator below:
Stacey Richardson
stlyrich@iu.edu
(317) 278-9215

PSC CALID

Enrolling: Yes

Principle Investigator: Craig Lammert, MD

Duration: 1 visit per year over 20 years

Patient Population: Patient population is PSC/pre-transplant with no history concomitant liver disease.

Interested in this study? Please contact the coordinator below:
Nan Ash
na1@iu.edu
(317) 278-6201

Progress PSC

Enrolling: Yes

Principle Investigator: Craig Lammert, MD

Duration: 1 visit.

Patient Population: Patients with PSC with ERCP, MRCP or liver biopsy.

Interested in this study? Please contact the coordinator below:
Kelsey Green
greenke@iu.edu
(317) 278-9292