4932-DeWitt, John
Faculty

John M. DeWitt, MD

Professor of Medicine

Address
University Hospital, Suite 1634
550 University Blvd
UH 4100
Indianapolis, IN 46202-5250
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Bio

Dr. DeWitt completed his undergraduate degree at the University of Virginia and medical degree (M.D.) at the Medical College of Viriginia (MCV). His internship at the University of North Carolina at Chapel Hill was followed by residency in internal medicine and fellowship in gastroenterology at MCV.  He completed training in advanced endoscopy at the University of Massachusetts.

Dr. DeWitt has been at Indiana University Health since 2001 where he is currently Professor of Medicine and Director of Endoscopic Ultrasound.  He has achieved national and international recognition for research in diagnostic and therapeutic endoscopic ultrasound and pioneered the use of endoscopy for the nonoperative ablation of pancreatic cystic neoplasms. In 2011, he started the submucosal endoscopy program at IU where he performed the first peroral endsocopic myotomy (POEM) for achalasia, first endoscopic submucosal dissection (ESD) for superficial tumors and the first flexible endoscopic treatment for Zenkers' diverticulum in the state of Indiana.  He has been active in multiple national societies including past chair of both the Standards of Practice Committee and Publications Commitee for the American Society of Gastrointestinal Endoscopy (ASGE) and past chair of the Imaging and Advanced Technology Section of the AGA Council.  He has published over 150 peer-reviewed papers and 150 abstracts on the diagnosis and treatment of gastrointestinal disease. 

Key Publications

Publications

1. DeWitt J, LeBlanc J, McHenry L, Ciaccia D, Imperiale T, Chappo J, Cramer H, McGreevy K, Chriswell M, Sherman, S. Endoscopic Ultrasound Guided-Fine Needle Aspiration Cytology of Solid Liver Lesions: A Large Single Center Experience.  Am J Gastroenterol 2003; 98:1976-81.   

2. DeWitt J, Devereaux B, Chriswell M, McGreevy K, Howard T, Imperiale TF, Ciaccia D, Kathleen Lane KA, Maglinte D, Kopecky K, LeBlanc J, McHenry L, Madura J, Aisen A, Cramer H, Cummings O, Sherman S. Comparison of Endoscopic Ultrasound and Multidetector Computed Tomography for the Detection and Staging of Pancreatic Cancer. Ann Int Med 2004; 141:753-763.

3. DeWitt J, Devereaux BM, Lehman GA, Sherman S, Imperiale TF.  Comparison of Endoscopic Ultrasound and Computed Tomography for the Preoperative Evaluation of Pancreatic Cancer:  A Systematic Review.  Clin Gastroenterol Hepatol 2006; 4:717-725.

4. Pais SA, Attasaranya S, LeBlanc JK, Sherman S, Schmidt CM, DeWitt J.  The Role of EUS in the Diagnosis of Intraductal Papillary Mucinous Tumors: Correlation with Surgical Histopathology. Clin Gastroenterol Hepatol 2007;5:489-95

5. DeWitt J, McGreevy K, Sherman S, Imperiale TF. Nurse-administered propofol sedation compared to midazolam and meperidine for endoscopic ultrasound: a prospective, randomized trial.  Gastrointest Endosc 2008;68:499-509

6. DeWitt J, McGreevy K, Cummings O, Sherman S, LeBlanc JK, McHenry L, Al-Haddad M, Chalasani N.  Initial Experience with Endoscopic Ultrasound-Guided Trucut Biopsy of Benign Liver Disease. Gastrointest Endosc 2009; 69:535-42

7. DeWitt J, McGreevy K, Schmidt CM, Brugge WR. Endoscopic Ultrasound-Guided Ethanol versus Saline Lavage for Pancreatic Cysts: A Randomized Double Blinded Study. Gastrointest Endosc 2009;70:710-723.

8.  Pais SA, Al-Haddad MA, Leblanc J, Sherman S, McHenry L, DeWitt JM. Endoscopic Ultrasound for Pancreatic Endocrine Tumors: A single center 11-year experience. Gastrointest Endosc 2010; 71:1185-93.

9. DeWitt J, Yu M, Al-Haddad MA, Sherman S, McHenry L, Leblanc J. Survival in patients with pancreatic cancer following the diagnosis of malignant ascites or liver metastases by EUS-FNA. Gastrointest Endosc 2010; 71:260-265.

10. DeWitt J, Al-Haddad M, Sherman S, LeBlanc J, Schmidt CM, Sandrasegaran K, Finkelstein SD. Alterations in Cyst Fluid Genetics Following Endoscopic Ultrasound Guided Pancreatic Cyst Ablation with Ethanol and Paclitaxel. Endoscopy 2014;46:457-464

11. Sey MS, Al-Haddad M, Imperiale TF, McGreevy K, Lin J, DeWitt JM. Endoscopic Ultrasound Guided Liver Biopsy for Parenchymal Disease. A comparison of diagnostic yield between two core biopsy needles. Gastrointest Endosc 2016; 83:347-52

12.  DeWitt JM, Murthy SK, Ardhanari R, DuVall GA, Wallner G, Litka P, Daugherty C, Fowers K. EUS-guided paclitaxel injection as an adjunctive therapy to systemic chemotherapy and concurrent external beam radiation before surgery for localized or locoregional esophageal cancer: a multicenter prospective randomized trial. Gastrointest Endosc 2017; 86:140-9

13. DeWitt JM, Sandrasegaran K, Perkins S, O’Neil B, House MG, Zyromski NJ, Sehdev A, McCranor L, Flynn, J, Shahda S.  Phase I study of EUS-guided Photodynamic Therapy for Locally Advanced Pancreatic Cancer.  Gastrointest Endosc 2019; 89:390-398

Videos

Gastrointestinal Endoscopy Author Interview Series. January 2019
https://youtu.be/FYfq-SksTis
For article published entitled, “Phase I study of EUS-guided photodynamic therapy for locally advanced pancreatic cancer”

Interview from Ecuadorian Institute of Digestive Diseases (IECED) in Ecuador during participation at a live endoscopy course. 2018
https://www.youtube.com/watch?v=e0Zh_3c8_Vc

Gastrointestinal Endoscopy Author Interview Series. November 2017
https://youtu.be/-1-wHA7_0X0
For article published entitled ”Endoscopic suturing of esophageal fully covered self-expanding metal stents reduces rates of stent migration” 

Gastrointestinal Endoscopy Author Interview Series. July 2017
https://www.youtube.com/watch?v=E47wcp4650
For article published entitled “EUS-guided oncogel injection as an adjunctive therapy to systemic chemotherapy and concurrent external beam radiation before surgery for localized or locoregional esophageal cancer: a multicenter prospective randomized trial”

Gastrointestinal Endoscopy Author Interview Series. June 2017
https://youtu.be/n7IAogmvw3g
For article published entitled “Sonographic and cyst fluid cytological changes after EUS-guided pancreatic cyst ablation”

Gastrointestinal Endoscopy Author Interview Series. April 2014
https://www.youtube.com/watch?v=zEsC-qMwyoQ
For article published entitled “Treatment of esophageal leaks, fistulae, and perforations with temporary stents: evaluation of efficacy, adverse events, and factors associated with successful outcomes.

Gastrointestinal Endoscopy Author Interview Series. October 2009
https://www.youtube.com/watch?v=SbGjR1aIL2I
For article published entitled “Endoscopic Ultrasound-Guided Ethanol versus Saline Lavage for Pancreatic Cysts: A Randomized Double Blinded Study” a short 7-8 minute video made and posted on YouTube with author explanation of pertinent study findings.

Podcasts

GIE Podcast hosted by Dr. Doug Adler for article entitled DeWitt JM, Murthy SK, Ardhanari R, DuVall GA, Wallner G, Litka P, Daugherty C, Fowers K. EUS-guided paclitaxel injection as an adjunctive therapy to systemic chemotherapy and concurrent external beam radiation before surgery for localized or locoregional esophageal cancer: a multicenter prospective randomized trial. Gastrointest Endosc 2017; 86:140-9.

http://www.giejournal.org/pb/assets/raw/Health%20Advance/journals/ymge/monthly_podcasts/YMGE_86_1_DeWitt.mp3

Titles & Appointments

  • Professor of Medicine

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