4932-DeWitt, John

John M. DeWitt, MD

Professor of Medicine

550 North University Blvd
Suite 4100
UH 4100
Indianapolis, IN 46202-5250
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Dr. DeWitt completed his undergraduate degree at the University of Virginia and medical degree (M.D.) at the Medical College of Virginia (MCV). His internship at the University of North Carolina at Chapel Hill was followed by residency in Internal Medicine and fellowship in Gastroenterology at MCV.  He completed training in advanced endoscopy at the University of Massachusetts.

Dr. DeWitt has been at Indiana University Health since 2001 where he is currently Professor of Medicine and Director of Endoscopic Ultrasound.  He has achieved national and international recognition for research in diagnostic and therapeutic endoscopic ultrasound and pioneered the use of endoscopy for the nonoperative ablation of pancreatic cystic neoplasms. In 2011, he started the submucosal endoscopy program at IU where he performed the first peroral endsocopic myotomy (POEM) for achalasia, first endoscopic submucosal dissection (ESD) for superficial tumors and the first flexible endoscopic treatment for Zenker's diverticulum in Indiana.  He has been active in multiple national societies including past chair of both the Standards of Practice Committee and Publications Committee for the American Society of Gastrointestinal Endoscopy (ASGE) and past chair of the Imaging and Advanced Technology Section of the AGA Council.  He has published over 160 peer-reviewed papers and 180 abstracts on the diagnosis and treatment of gastrointestinal disease. 

Key Publications


1. DeWitt J, LeBlanc J, McHenry L, Ciaccia D, Imperiale T, Chappo J, Cramer H, McGreevy K, Chriswell M, Sherman, S. Endoscopic Ultrasound Guided-Fine Needle Aspiration Cytology of Solid Liver Lesions: A Large Single Center Experience.  Am J Gastroenterol 2003; 98:1976-81.   

2. DeWitt J, Devereaux B, Chriswell M, McGreevy K, Howard T, Imperiale TF, Ciaccia D, Kathleen Lane KA, Maglinte D, Kopecky K, LeBlanc J, McHenry L, Madura J, Aisen A, Cramer H, Cummings O, Sherman S. Comparison of Endoscopic Ultrasound and Multidetector Computed Tomography for the Detection and Staging of Pancreatic Cancer. Ann Int Med 2004; 141:753-763.

3. DeWitt J, Devereaux BM, Lehman GA, Sherman S, Imperiale TF.  Comparison of Endoscopic Ultrasound and Computed Tomography for the Preoperative Evaluation of Pancreatic Cancer:  A Systematic Review.  Clin Gastroenterol Hepatol 2006; 4:717-725.

4. Pais SA, Attasaranya S, LeBlanc JK, Sherman S, Schmidt CM, DeWitt J.  The Role of EUS in the Diagnosis of Intraductal Papillary Mucinous Tumors: Correlation with Surgical Histopathology. Clin Gastroenterol Hepatol 2007;5:489-95

5. DeWitt J, McGreevy K, Sherman S, Imperiale TF. Nurse-administered propofol sedation compared to midazolam and meperidine for endoscopic ultrasound: a prospective, randomized trial.  Gastrointest Endosc 2008;68:499-509

6. DeWitt J, McGreevy K, Cummings O, Sherman S, LeBlanc JK, McHenry L, Al-Haddad M, Chalasani N.  Initial Experience with Endoscopic Ultrasound-Guided Trucut Biopsy of Benign Liver Disease. Gastrointest Endosc 2009; 69:535-42

7. DeWitt J, McGreevy K, Schmidt CM, Brugge WR. Endoscopic Ultrasound-Guided Ethanol versus Saline Lavage for Pancreatic Cysts: A Randomized Double Blinded Study. Gastrointest Endosc 2009;70:710-723.

8.  Pais SA, Al-Haddad MA, Leblanc J, Sherman S, McHenry L, DeWitt JM. Endoscopic Ultrasound for Pancreatic Endocrine Tumors: A single center 11-year experience. Gastrointest Endosc 2010; 71:1185-93.

9. DeWitt J, Yu M, Al-Haddad MA, Sherman S, McHenry L, Leblanc J. Survival in patients with pancreatic cancer following the diagnosis of malignant ascites or liver metastases by EUS-FNA. Gastrointest Endosc 2010; 71:260-265.

10. DeWitt J, Al-Haddad M, Sherman S, LeBlanc J, Schmidt CM, Sandrasegaran K, Finkelstein SD. Alterations in Cyst Fluid Genetics Following Endoscopic Ultrasound Guided Pancreatic Cyst Ablation with Ethanol and Paclitaxel. Endoscopy 2014;46:457-464

11. Sey MS, Al-Haddad M, Imperiale TF, McGreevy K, Lin J, DeWitt JM. Endoscopic Ultrasound Guided Liver Biopsy for Parenchymal Disease. A comparison of diagnostic yield between two core biopsy needles. Gastrointest Endosc 2016; 83:347-52

12.  DeWitt JM, Murthy SK, Ardhanari R, DuVall GA, Wallner G, Litka P, Daugherty C, Fowers K. EUS-guided paclitaxel injection as an adjunctive therapy to systemic chemotherapy and concurrent external beam radiation before surgery for localized or locoregional esophageal cancer: a multicenter prospective randomized trial. Gastrointest Endosc 2017; 86:140-9

13. DeWitt JM, Sandrasegaran K, Perkins S, O’Neil B, House MG, Zyromski NJ, Sehdev A, McCranor L, Flynn, J, Shahda S.  Phase I study of EUS-guided Photodynamic Therapy for Locally Advanced Pancreatic Cancer.  Gastrointest Endosc 2019; 89:390-398

DeWitt JM, Arain M, Chang KJ, Sharaiha R, Komanduri S, Muthusamy VR, Hwang JH; AGA Center for GI Innovation and Technology. Interventional Endoscopic Ultrasound: Current Status and Future Directions. Clin Gastroenterol Hepatol. 2021 Jan;19(1):24-40.  

Titles & Appointments

  • Professor of Medicine

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