Maternal-Fetal Medicine Research

Principal Investigator: Hiba Mustafa, MD

Coordinator: Rachel Tullar

This study aims to investigate the hypothesis that delivery at 35 0/7- 35 6/7 weeks in stable patients with gastroschisis is superior to observation and expectant management with a goal of delivery at 38 0/7 - 38 6/7 weeks. We will complete a randomized, prospective, multi-institutional trial across NAFTNet-affiliated institutions to test this hypothesis. Patients may be enrolled in the study any time before 33 weeks but will be randomized at 33 weeks to delivery at 35 weeks or observation with a goal of 38 weeks. The primary composite outcome will include stillbirth, neonatal death before discharge, respiratory morbidity and the need for parenteral nutrition at 30 days.

Principal Investigator: Christina Scifres, MD

Coordinator: Sarah Oswalt

The expected outcome of this study is high-quality evidence of the effectiveness, safety, and cost-effectiveness of intensive glycemic targets in reducing adverse perinatal outcomes among overweight and obese women with GDM. If proven effective, the use of intensive glycemic targets in overweight and obese women with GDM will have a significant positive impact on the health of these high-risk women and their infants.  

Principal Investigator: Christina Scifres, MD

Coordinator: Sarah Oswalt

The goal of PRAM-T1D is to collect real-world data on strategies currently employed by pregnant individuals with T1D in the United States to manage their disease and assess glycemic and pregnancy outcomes associated with these strategies, with a particular focus on the use of diabetes technology. 

Principal Investigator: Brownsyne Tucker Edmonds, MD, MPH

Coordinator: Shelley Hoffman

Pregnant people in Indiana experience mortality and morbidity at rates that significantly outpace the national average. Of the reviewed pregnancy-related deaths in Indiana in 2020, the Indiana State Department of Health determined 87% of these to be preventable. Indiana data suggests using additional pregnancy healthcare specialists, such as doulas, could reduce these rates. Birth doulas are trained to provide physical, emotional, and educational support to birthing people during the prenatal period, labor, birth and immediately postpartum.