The Indiana University Genome Editing Center at Indiana University School of Medicine is an institutionally subsidized shared resource whose mission is to provide Indiana University and external investigators access to state-of-the-art genome editing technologies by assisting with the generation of genetically modified organisms in a time- and cost-effective manner. The center, established in July 2020, exploits various technologies, including CRISPR-based genome editing systems, conventional gene targeting in embryonic stem cells and transgenesis, to engineer genetically modified transformed cell lines, stem cells and animals that will help identify and validate novel therapeutic targets, accelerate translational research, and advance precision medicine.
Latest updates from the Genome Editing Center
Due to several new developments at the IUGEC, model production is moving ahead at a record pace. These improvements have not only allowed us to drastically increase the editing rate for our mouse models, but have also resulted in the successful completion of genetically engineered stem cell lines. The IUGEC is proud to announce that in addition to meeting our goals for the first three years of the core, we are now well on our way to completing the majority of our remaining ongoing projects. That being said, the IUGEC is excited for the opportunity to take on new projects and/or collaborations at this time. To schedule an appointment regarding potential projects, please reach out to Destinée Thomas at destthom@iu.edu.
The Genome Editing Center is located in the Medical Library and Research Building room IB237, IB237A/B, IB250 and LARC. The center is outfitted with state-of-the-art molecular biology, cell biology, biochemistry, tissue culture, microinjection, surgery, and cryopreservation equipment.
88
model generation services completed
22
ongoing model generation services
293
traditional transgenic services completed
6
ongoing traditional transgenic services