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Service Cores
Behavioral Phenotyping
Capabilities
Physiological and Behavioral Capabilities
The Behavioral Phenotyping Core at IU School of Medicine offers the following in vivo physiological and behavioral capabilities.
Basic Sensory/Motor/Reflexive/Autonomic/Consummatory Function
Frailty index, grip strength, & negative geotaxis reflex
Motor function (rotarod / wheel running coordination)
Acoustic and tactile startle reactivity
24-hr home-cage core body temperature + activity (circadian rhythm integrity). Capabilities to measure HR/BP and EEG.
24-hr food / liquid intake patterns; taste preferences
Affective Reactivity/Aggression
Startle responsivity (dark vs enhanced light conditions)
Social approach / withdrawal
Stress-induced hyperthermia
Open-field activity w/ light:dark preference
Novelty neophobia
Social dominance behavior
Resident intruder aggression
Forced swim / Tail suspension (‘behavioral despair’)
Elevated plus maze
Addiction
Reward-seeking / compulsive drinking:
2-bottle access
Schedule-induced polydipsia
Dependence:
Autonomic measurement of withdrawl
Somatic endpoints [e.g. activity / circadian changes]
Dysphoria / anhedonia [e.g. sucrose preference, immobility in forced swim / tail suspension]
Attention/Cognition
Habituation / dishabituation of startle / open-field activity (
nonassociative learning
)
Prepulse inhibition (
sensorimotor gating
)
Spontaneous & food-reinforced Y-maze alternation (
working memory
)
Novel object recognition (
short-term memory
)
Social recognition / learning (
ethological memory processes
)
One-trial inhibitory avoidance (
memory consolidation/retrieval
)
Active avoidance acquisition / Go, No-Go discrimination (
mesolimbic DA, executive function
)
8-arm radial (dry) maze (
spatial learning & memory
)
Morris water maze (
spatial learning & memory
)
Active Place Avoidance (spatial learning & memory)
Classical fear (tone/context) conditioning (
associative learning
;
amygdala/hippocampal circuits
)
Conditioned taste aversion (
long-term memory; attentional processes
)
Pain
Volitional wheel running (
motivational processes
)
Standard acute nociception assays (e.g. mechanical allodynia via Von Frey or algometer)
Volitional 2-plate thermal place preference (hot-cold allodynia)
Automated shock sensitivity thresholds using flinch response
IN THIS SECTION
3D Bioprinting
Behavioral Phenotyping
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Capabilities
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Chemical Genomics
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Medicinal and Analytical Chemistry
High-Throughput Screening
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Clinical Pharmacology Analytical
Electron Microscopy
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Genome Editing
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Histology
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Imaging and Flow Cytometry
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Immunohistochemistry
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Medical Genomics
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Confidentiality
Conflict Resolution
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RNA-Sequencing
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Proteomics
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Research Imaging
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