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Molecular Oncology and Experimental Therapeutics

The Pediatric Molecular Oncology and Experimental Therapeutics research team is focused on translating the basic science understanding of genes and protein mechanisms into new therapeutic modalities while developing better models for tumor studies and a greater understanding of tumor biology. The group puts emphasis on all types of pediatric cancers and related tumors, including sarcomas (osteosarcoma and rhadbomyosarcoma). Basic and preclinical studies facilitate clinical trials as well as understanding mechanism of the diseases.

Areas of Focus

The current areas of research for the Pediatric Molecular Oncology and Experimental Therapeutics group include DNA repair, epigenetics, signaling pathways, oncoproteins, tumor suppressors, angiogenesis and development of novel therapeutics, tumor-microenvironment interaction, and chemotherapy-induced peripheral neuropathy (CIPN).

Learn more about the program's active research

Personalized cancer therapy entails targeting and optimizing treatments to the patient. This includes clinical pharmacology of anti-cancer drugs, genetic assessment of each patient’s ability to tolerate treatment and identification of genetic biomarkers in DNA and proteins that predict therapy response.

7 principal investigators
12 trainees
$6 million annually in research funds

Cross Collaboration

Faculty members from the Pediatric Molecular Oncology and Experimental Therapeutics program work in partnership with like-minded faculty and researchers across IU School of Medicine and beyond to forge innovative cancer research.

Team members are proud to collaborate with the Melvin and Bren Simon Comprehensive Cancer Center, Center for HPV Research, the Eugene and Marilyn Glick Eye Institute, and other advocates committed to advancing transformational research.

Meet the Molecular Oncology & Experimental Therapeutics group

Featured News

A portrait of a smiling man.

Commitment to excellence

D. Wade Clapp, MD, and Mark R. Kelley, PhD, from the Pediatric Molecular Oncology and Experimental Therapeutics program were two of six Indiana University faculty members elected to the 2021 class of fellows of the American Association for the Advancement of Science. This is one of the most distinguished honors within the scientific community, which recognizes outstanding contributions to the progress of science and research.

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Improving outcomes

Karen E. Pollok, PhD, is the lead researcher for two new grants totaling nearly $2M to support osteosarcoma research which was built on previous research made possible by Tyler Trent's tumors. Tyler was a Purdue University student and football superfan who died in 2019, after waging a long and valiant fight against an aggressive form of bone cancer.

Wade Clapp, MD

Bench to bedside

D. Wade Clapp, MD, and his team of scientists are among the world’s foremost experts on neurofibromatosis type 1 (NF1), a rare and potentially fatal genetic condition. Clapp’s work has lead to several of clinical trials and improved quality of life for children with NF1 and their families.

Passion and purpose

Early losses led to a career in cancer research for Melissa Fishel, PhD. Now, she uses this inspired purpose to uncover the mysteries of cancerous cells by developing improved model systems.

HPV and its role in cancer

Rachel Katzenellenbogen, MD, joined IU School of Medicine as the inaugural Chuck and Tina Pagano Scholar in 2018. Her research is focused on human papillomavirus (HPV), a very common infection that affects more than 75 percent of the adult population. Learn more about Dr. Katzenellenbogen.