Over the last 25 years, hundreds of clinical trials for drugs treating Alzheimer’s disease have failed. As the field takes stock, a team at IU School of Medicine hunts for new targets—and hope for patients.
I AM CURLED up on my side, knees to my chest, hospital gown gaping in the back, when Liana Apostolova, MD, pulls out a needle that looks big enough to use on a baby elephant and takes aim at the space between a pair of vertebrae in my lower back. I am neither ill nor injured. I don’t have to be here. I am here for the sake of science—and because Apostolova is good at asking people to do this. […]
RESEARCH INDICATES that exercise can reduce the risk of Alzheimer’s disease. The problem, however, is that we don’t know why. By understanding the precise processes happening in the body when we exercise, Bruce Lamb, PhD, who holds the Roberts Family Chair in Alzheimer’s Disease Research, hopes to replicate the mechanisms with new drugs or therapies. Specifically, Lamb will study what role exercise may play in reducing inflammation and how this is linked to Alzheimer’s disease. By understanding the precise processes happening in the body […]
DAVE ROBERTS is all about speed. The North Carolina-based businessman cultivated a love of racing at an early age and has amassed a collection of autos that would make any fan jealous. There’s the 1978 Indy car that ran in the 500. A coveted ’16 Porsche and an ’08 Corvette. And the ’69 yellow-and-blue Camaro he partnered with Indy Car driver Alex Lloyd to race in the 2016 pro-am Brickyard Vintage Racing Invitational at the Indianapolis Motor Speedway. The multinational […]
PEER BAEKGAARD had a knack for cheating death. As a young man growing up in Denmark during World War II, he joined the Danish Underground and helped Jews flee to freedom. He was eventually captured by the Nazis, shipped by train to a prisoner-of-war camp, and sentenced to die. On one occasion, Peer and his five cell mates complained to a seemingly friendly guard that their cramped quarters meant they had to sleep in shifts. The guard asked for volunteers. […]
TO ANDREW Saykin, PSYD, Alzheimer’s disease is a race against time. He and other researchers now believe that most forms of dementia begin to develop at least two decades before someone arrives at a doctor’s office worried about misplaced keys or slipping memory. By that point, the damage could be irreversible. “It could be 20 or 30 years too late,” said Saykin, director of the Indiana Alzheimer Disease Center at the Indiana University School of Medicine. “To actually do something […]