Over the last 25 years, hundreds of clinical trials for drugs treating Alzheimer’s disease have failed. As the field takes stock, a team at IU School of Medicine hunts for new targets—and hope for patients.
COMBING THE SCIENTIFIC literature, Tim Corson, PhD, searched for a new way to treat macular degeneration, the deterioration of part of the retina. It led to him to an unlikely place. A delicate orchid. Or more accurately, a medicinal compound the orchid produces. Patients diagnosed with wet age-related macular degeneration spend their golden years in a gauzy haze. Inside their eye, abnormal blood vessels sprout underneath tissue in the center of the retina. These vessels leak fluid, creating scar tissue. […]
XIONGBIN LU, PhD, spends his days engrossed in research into the factors that lead normal breast tissue cells to turn into Triple Negative Breast Cancer—and engineering therapies to stop it. Across the hall from Lu’s lab, Xinna Zhang, PhD, dives deeply into her the study of the biology of HER2-positive breast cancer, and what makes cells resistant to drug therapies. But Lu and Zhang share more than their proximity to one another in the Vera Bradley Foundation Breast Cancer Research […]
THE PAIN pulsing in James Mikesh’s lower back was so bad it shook him from his sleep. When it hit, Mikesh—then a senior at the University of Minnesota—would trudge into his bathroom, turn on the knobs in his bathtub and slip into warm water, searching for relief. For a while, that was enough. Then the pain spread to his groin, and Mikesh sought help. It took little time for an oncologist to diagnose the problem: Testicular cancer, stage 3. At […]
IN THE fight against one of the most aggressive forms of breast cancer, an Indiana University School of Medicine researcher is refining what he hopes will be a weapon as deadly as its foe—a “nanobomb.” Xiongbin Lu, PhD, the Vera Bradley Foundation Professor of Breast Cancer Innovation, is working on a microscopic cancer-fighting tool that—in its assault on triple negative breast cancer cells—acts almost like a Trojan horse, but with an explosive twist. Lu’s nanobomb is a pair of cancer […]