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Electrophysiology Research

Indiana University School of Medicine researchers have a strong legacy as pioneers of cardiac electrophysiology. Their seminal contributions inform the current understanding of the mechanics of fibrillation and defibrillation, the development and implantation of the transvenous cardioverter to prevent cardiac arrest and the evolution of the electrocardiogram. Today, investigators of the Krannert Cardiovascular Research Center are continuing to advance the electrophysiology through research at the molecular and cellular level, incorporating novel biomedical engineering approaches to contribute new findings regarding arrhythmogenesis in adults.

Illustration comparing normal heart to one with Atrial Fibrillation.

A normal heart normally pumps 60 to 100 times per minute to circulate blood throughout the human body and is managed by a network of cells that operate the body’s cardiac conduction system, otherwise known as the heart’s electrical system. However, more than 1.5 to 5 percent of the general population experience arrhythmia, an abnormal rhythm of the heart. When heart rhythm is impaired, electrical impulses may run too fast (tachycardia), too slow (bradycardia) or irregularly (fibrillation).

Arrhythmias can also begin in the ventricles or just above the ventricles. Left untreated, arrhythmias could damage a person’s brain, lungs, heart or other vital organs, and could lead to heart failure, stroke, dementia or cardiac arrest, culminating in sudden death.

Much of the electrophysiology research conducted at KCVRC focus on the following areas:

  • Molecular and Cellular Regulation of Cardiac Ion Transport Proteins

  • Modeling Cardiac Arrhythmias with iPSC-derived cells

  • Biomedical Engineering Approaches in Electrophysiology

Electrophysiology Research Team

HS V. Chen, BMED, PhD

Associate Professor of Medicine

Zhenhui Chen, PhD

Associate Professor of Medicine

Ankit A. Desai, MD

Associate Professor of Medicine

Thomas H. Everett, PhD

Associate Professor of Medicine

Douglas P. Zipes, MD

Distinguished Professor Emeritus

IU School of Medicine Collaborators

Electrophysiology Research Fellows

Md Aktaruzzaman, PhD

Postdoctoral Fellow in Medicine

Chirag D. Shah, MD, MPH

Eastern Virginia Medical School

Undergraduate Students

portrait of Molly Dye

Molly Dye

Purdue University, Weldon School of Biomedical Engineering

External Collaborators 

Steve Cala, PhD, Associate Professor of Physiology – Wayne State University

Peng-Sheng Chen, MD, Burns and Allen Chair in Cardiology Research, Cedars Sinai

Xuequn Chen, PhD, Associate Professor of Physiology – Wayne State University

Bradley Duerstock, PhD, Professor of Engineering Practice, Purdue University, Weldon School of Biomedical Engineering

Evangelia G. Kranias, PhD, Director of Cardiovascular Biology, Co-Director, Cardiovascular Center of Excellence, Hanna Chair of Cardiology, University of Cincinnati College of Medicine

Rengasayee Veeraraghavan, PhD, Associate Professor of Biomedical Engineering – The Ohio State University

Matthew Ward, PhD, Assistant Professor of Biomedical Engineering, Purdue University, Weldon School of Biomedical Engineering