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Ischemic Heart Disease Clinical Trials

Hispanic older couple pictured with wife embracing husband around the shoulder. Ischemic heart disease, also known as coronary artery disease, stems from reduced oxygen supply to the heart muscle from the plaque built up in someone's arteries. 

This disease remains the most common cause of death in western countries and according to the National Heart, Lung and Blood Institute, approximately 366,000 Americans die from ischemic heart disease annually.

Our clinical trials in ischemic heart disease investigate the structural, compositional and functional changes to the heart at early, progressive and terminal stages of ischemic heart disease, using MRI technology, positron emission tomography or PET, a type of nuclear medicine that measures metabolic activity of cells, and CT technology. 

Current Clinical Trials

Iron Chelation Therapy (ICT) Study: Randomized, controlled pilot study to determine Cardiac MRI-guided Deferiprone Therapy for Acute Myocardial Infarction Patients

Objective: To evaluate the clinical translatability of intracellular iron chelation therapy (ICT) toward reduction of iron concentration in infarcted myocardium among acute MI patients with intramyocardial hemorrhage.

PI: Rohan Dharmakumar, PhD

Status: Now Enrolling  

NCT No. NCT05604131


Ischemic Heart Disease Registry

Objective: The main objective of the registry is to evaluate the association between outpatient investigations, inpatient treatments and out of hospital clinical outcomes in both the short and long term.

PI: Rohan Dharmakumar, PhD

Status: Registry

NCT No. N/A

 

Pilot trial to determine Relationship between Troponin Kinetics and Hemorrhagic MI

Objective: The primary objective of this study is to determine the quantitative threshold differences in troponin-I level between hemorrhagic and non-hemorrhagic myocardial infarction. 

PI: Rohan Dharmakumar, PhD

Status: Enrolling By Invitation

NCT No. N/A

 

Selatogrel Outcome Study in Suspected Acute Myocardial Infarction (SOS-AMI)

Objective: This multicenter, double-blind, randomized, placebo-controlled, parallel-group study evaluates the efficacy and safety of self-administered subcutaneous Selatogrel for prevention of all-cause death and treatment of acute myocardial infarction in subjects with a recent history of acute myocardial infarction.

PI: Rolf P. Kreutz, MD

Status: Now Enrolling

NCT No. NCT04957719

 

TRIUMPH OUTCOMES STUDY: The Effect of Retatrutide Once Weekly on Cardiovascular Outcomes and Renal Function in Adults Living With Obesity

Objective: To determine if retatrutide can significantly lower the incidence of serious heart-related complications or prevent the worsening of kidney function. The trial will enroll adults with a body mass index (BMI) ≥27 kg/m2 and Atherosclerotic Cardiovascular Disease (ASCVD) and/or chronic kidney disease (CKD).

PI: Suparna Clasen, MD

Status: Now Enrolling

NCT No. NCT06383390

Utilizing Carbon Dioxide for Assessing Coronary Blood Flow in Subjects with Coronary Artery Disease (NIMO-CAD)

Objective: The purpose of this study is to evaluate the safety, tolerability and technical feasibility of utilizing carbon dioxide for assessing coronary blood flow in subjects with coronary artery disease.

PI: Rohan Dharmakumar, PhD

Status: Not yet recruiting

NCT No. NCT06253884

 


Email the clinical research team to learn more and participate.

Featured Publications

Intramyocardial Hemorrhage Drives Fatty Degeneration of Infarcted Myocardium
Cokic I, Chang SF, Nair AR, Guan X, Yang HJ, Liu T, Chen Y, Hernando D, Sykes J. Tang R, Butler J, Dohnalkova A, Kovarik L, Finney R, Kali A, Sharif B, Bouchard L, Gupta R, Krishnam MS, Vora K, Tamarappoo B, Howarth A, Kumar A, Francis J, Reeder SB, Woo JC, Prato FS, Dharmakumar R. Nat Commun 13, 6394 (2022)

A Multi-Center Study on the Diagnostic Performance of Native- T1 CMR of Chronic Myocardial Infarctions at 3T
Wang G, Lee S, Yang Q, Sadras V, Patel S, Yang HJ, Sharif B, Kali A, Cokic I, Tighiouart M, Collins J, Li D, Berman DS, Chang HJ, Dharmakumar R. Circulation: Cardiovascular Imaging, 2020, June.

PRINCIPAL INVESTIGATOR
60337-Dharmakumar, Rohan

Rohan Dharmakumar, PhD

Director for Cardiovascular Imaging Research, Indiana Institute for Biomedical Imaging Sciences

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PRINCIPAL INVESTIGATOR
5070-Kreutz, Rolf

Rolf P. Kreutz, MD

Professor of Clinical Medicine

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PRINCIPAL INVESTIGATOR
44716-Clasen, Suparna

Suparna C. Clasen, MD, MSCE

Assistant Professor of Clinical Medicine

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Investigators

60685-Vora, Keyur

Keyur Vora, M.D.

Assistant Research Professor of Radiology & Imaging Sciences

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40541-Sharif, Marina

Marina Sharif, MD

PGY 6
Indiana University School of Medicine

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Faculty Profile Picture Placeholder IUSM Logo

Huaibi Huo, MD

Visiting Scholar in Medicine

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