Cardiopulmonary research explores the molecular underpinnings of heart and lung disorders utilizing precision medicine tools and techniques. This includes understanding the mechanisms and genetics of pulmonary arterial hypertension, a condition that affects the blood vessels in the lungs, and sickle cell cardiomyopathy, which could lead to sudden death.
Pulmonary arterial hypertension largely affects women (4:1 female to male ratio) with survival rates estimated to be around 50% at 7 years despite the addition of multiple therapies.
Studies are aimed at new molecular pathways that are discovered from genetic studies in patients and translating them as targets for novel therapies.