Zhenhui Chen, PhD

Faculty

Zhenhui Chen, PhD

Associate Professor of Medicine

Phone (317) 274-0964

Address

Krannert Institute of Cardiology, Room E400
1801 N. Senate Blvd., Suite E400

Indianapolis, IN 46202-1228

Bio

Dr. Chen received his PhD degree from the Indiana University School of Medicine in the field of medical biophysics. He was a postdoctoral fellow at the Institute of Molecular Cardiobiology at The Johns Hopkins University School of Medicine in Baltimore, Maryland. He currently serves as an assistant research professor at the IU School of Medicine and the Krannert Institute of Cardiology.

Titles & Appointments

Associate Professor of Medicine

Education

2000 FEL Postdoctoral Fellowship, Institute of Molecular Cardiobiology, The Johns Hopkins University School of Medicine, Baltimore, MD

1997 PhD Indiana University

1990 MS Nankai University

1987 BS Nankai University
Publications

Phospholamban regulates nuclear Ca<sup>2+</sup> stores and inositol 1,4,5-trisphosphate mediated nuclear Ca<sup>2+</sup> cycling in cardiomyocytes.
Chen M; Xu D; Wu AZ; Kranias E; Lin SF; Chen PS; Chen Z; 2018 Sep 24

Role of apamin sensitive small conductance calcium-activated potassium currents in long term cardiac memory in rabbits.
Yin D; Chen M; Yang N; Wu AZ; Xu D; Tsai WC; Yuan Y; Tian Z; Chan YH; Shen C; Chen Z; Lin SF; Weiss JN; Chen PS; Everett TH 4th; Heart rhythm 2018 Jan 8

Long-term intermittent high-amplitude subcutaneous nerve stimulation reduces sympathetic tone in ambulatory dogs.
Yuan Y; Jiang Z; Zhao Y; Tsai WC; Patel J; Chen LS; Shen C; Lin SF; Chen HV; Everett TH 4th; Fishbein MC; Chen Z; Chen PS; Heart rhythm 2017 Nov 27

Phospholamban is concentrated in the nuclear envelope of cardiomyocytes and involved in perinuclear/nuclear calcium handling.
Wu AZ; Xu D; Yang N; Lin SF; Chen PS; Cala SE; Chen Z; Journal of molecular and cellular cardiology 2016 Sep 15

Acute reversal of phospholamban inhibition facilitates the rhythmic whole-cell propagating calcium waves in isolated ventricular myocytes.
Chan YH; Tsai WC; Song Z; Ko CY; Qu Z; Weiss JN; Lin SF; Chen PS; Jones LR; Chen Z; Journal of molecular and cellular cardiology 2015 Jan 14

Small Conductance Calcium-Activated Potassium Current is Important in Transmural Repolarization of Failing Human Ventricles.
Yu CC; Corr C; Shen C; Shelton R; Yadava M; Rhea I; Straka S; Fishbein MC; Chen Z; Lin SF; Lopshire JC; Chen PS; Circulation. Arrhythmia and electrophysiology 2015 Apr 23

Competitive displacement of wild-type phospholamban from the Ca2+-free cardiac calcium pump by phospholamban mutants with different binding affinities.
Chen Z; Journal of molecular and cellular cardiology 2014 Sep 3

Apamin-sensitive calcium-activated potassium currents in rabbit ventricles with chronic myocardial infarction.
Lee YS; Chang PC; Hsueh CH; Maruyama M; Park HW; Rhee KS; Hsieh YC; Shen C; Weiss JN; Chen Z; Lin SF; Chen PS; Journal of cardiovascular electrophysiology 2013 May 29

Amiodarone inhibits apamin-sensitive potassium currents.
Turker I; Yu CC; Chang PC; Chen Z; Sohma Y; Lin SF; Chen PS; Ai T; PloS one 2013 Jul 29

Low-level vagus nerve stimulation upregulates small conductance calcium-activated potassium channels in the stellate ganglion.
Shen MJ; Hao-Che Chang; Park HW; George Akingba A; Chang PC; Zheng Zhang; Lin SF; Shen C; Chen LS; Chen Z; Fishbein MC; Chiamvimonvat N; Chen PS; Heart rhythm : the official journal of the Heart Rhythm Society 2013 Jan 26

Apamin-sensitive potassium current modulates action potential duration restitution and arrhythmogenesis of failing rabbit ventricles.
Hsieh YC; Chang PC; Hsueh CH; Lee YS; Shen C; Weiss JN; Chen Z; Ai T; Lin SF; Chen PS; Circulation. Arrhythmia and electrophysiology 2013 Feb 18

Triggered firing and atrial fibrillation in transgenic mice with selective atrial fibrosis induced by overexpression of TGF-ß1.
Choi EK; Chang PC; Lee YS; Lin SF; Zhu W; Maruyama M; Fishbein MC; Chen Z; Rubart-von der Lohe M; Field LJ; Chen PS; Circulation journal : official journal of the Japanese Circulation Society 2012 Mar 22

Imaging arrhythmogenic calcium signaling in intact hearts.
Chen PS; Ogawa M; Maruyama M; Chua SK; Chang PC; Rubart-von der Lohe M; Chen Z; Ai T; Lin SF; Pediatric cardiology 2012 Feb 17

A phospholamban-tethered cardiac Ca2+ pump reveals stoichiometry and dynamic interactions between the two proteins.
Chen Z; The Biochemical journal 2011 Oct 15

Small-conductance calcium-activated potassium channel and recurrent ventricular fibrillation in failing rabbit ventricles.
Chua SK; Chang PC; Maruyama M; Turker I; Shinohara T; Shen MJ; Chen Z; Shen C; Rubart-von der Lohe M; Lopshire JC; Ogawa M; Weiss JN; Lin SF; Ai T; Chen PS; Circulation research 2011 Feb 24

Superinhibitory phospholamban mutants compete with Ca2+ for binding to SERCA2a by stabilizing a unique nucleotide-dependent conformational state.
Akin BL; Chen Z; Jones LR; The Journal of biological chemistry 2010 Jul 11

Mechanisms of sinoatrial node dysfunction in a canine model of pacing-induced atrial fibrillation.
Joung B; Lin SF; Chen Z; Antoun PS; Maruyama M; Han S; Piccirillo G; Stucky M; Zipes DP; Chen PS; Das MK; Heart rhythm : the official journal of the Heart Rhythm Society 2009 Sep 16

Ca2+ binding to site I of the cardiac Ca2+ pump is sufficient to dissociate phospholamban.
Chen Z; Akin BL; Jones LR; The Journal of biological chemistry 2009 Nov 30

Intracellular calcium dynamics and acceleration of sinus rhythm by beta-adrenergic stimulation.
Joung B; Tang L; Maruyama M; Han S; Chen Z; Stucky M; Jones LR; Fishbein MC; Weiss JN; Chen PS; Lin SF; Circulation 2009 Feb 2

The initiation of the heart beat.
Chen PS; Joung B; Shinohara T; Das M; Chen Z; Lin SF; Circulation journal : official journal of the Japanese Circulation Society 2009 Dec 18

Mechanism of reversal of phospholamban inhibition of the cardiac Ca2+-ATPase by protein kinase A and by anti-phospholamban monoclonal antibody 2D12.
Chen Z; Akin BL; Jones LR; The Journal of biological chemistry 2007 Jun 4

Cross-linking of C-terminal residues of phospholamban to the Ca2+ pump of cardiac sarcoplasmic reticulum to probe spatial and functional interactions within the transmembrane domain.
Chen Z; Akin BL; Stokes DL; Jones LR; The Journal of biological chemistry 2006 Mar 22

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