Zhenhui Chen, PhD, MS

Dr. Zhenhui Chen is an Associate Professor within the Department of Medicine.  His research focuses on biochemical and biophysical characterizations of ion transports (pumps and ion channels) in cardiac myocytes. Dr. Chen’s research has been funded by the NIH and AHA. 

Dr. Chen earned his undergraduate degree from Nankai University and his PhD degree from Indiana University. He completed his research fellowships at Johns Hopkins University.

Chen Z, Song Y-L, Chen PS, Li X, Guo J.  Na⁺, K⁺-Pump/Phospholemman Are Concentrated at Intercalated Discs for Conduction. Circ. Res. 2022 Jul 22;131(3):283-285. doi: 10.1161/CIRCRESAHA.122.321167. Epub 2022 Jun 30. PubMed PMID: 35770663; PubMed Central PMCID: PMC9308724.

He W, Huang D, Guo S, Wang D, Guo J, Cala SE and Chen Z. Association with SERCA2a directs phospholamban trafficking to sarcoplasmic reticulum from a nuclear envelope pool. J Mol Cell Cardiol. 2020;143:107-119. doi.org/10.1016/j.yjmcc.2020.04.025. PMID: 32353354.

Chen M, Xu D, Wu AZ, Kranias EK, Lin SF, Chen PS, Chen Z.  Phospholamban Regulates Nuclear Ca²⁺ Stores and Inositol 1,4,5-Trisphosphate Mediated Nuclear Ca²⁺ Cycling in Cardiomyocytes. J. Mol. Cell. Cardiol., 2018, Oct;123:185-197. PMID:30261161.  

Wu AZ, Xu D, Yang N, Lin SF, Chen PS, Cala SE, Chen Z. Phospholamban is concentrated in the nuclear envelope of cardiomyocytes and involved in perinuclear/nuclear calcium handling. J. Mol. Cell. Cardiol. 2016;100:1-8. doi: 10.1016/j.yjmcc.2016.09.008. PubMed PMID: 27642167.