4842-Chen, Zhenhui

Zhenhui Chen, PhD

Associate Professor of Medicine

Krannert Cardiovascular Research Center
1801 N. Senate Blvd., Suite E312 (E371 Mailing Address)

Indianapolis, IN 46202-1228
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Dr. Zhenhui Chen is an Associate Professor within the Department of Medicine.  His research focuses on biochemical and biophysical characterizations of ion transports (pumps and ion channels) in cardiac myocytes. Dr. Chen’s research has been funded by the NIH and AHA. 

Dr. Chen earned his undergraduate degree from Nankai University and his PhD degree from Indiana University. He completed his research fellowships at Johns Hopkins University.

Key Publications

Chen Z, Song Y-L, Chen PS, Li X, Guo J.  Na+, K+-Pump/Phospholemman Are Concentrated at Intercalated Discs for Conduction. Circ. Res. 2022 Jul 22;131(3):283-285. doi: 10.1161/CIRCRESAHA.122.321167. Epub 2022 Jun 30. PubMed PMID: 35770663; PubMed Central PMCID: PMC9308724.

He W, Huang D, Guo S, Wang D, Guo J, Cala SE and Chen Z. Association with SERCA2a directs phospholamban trafficking to sarcoplasmic reticulum from a nuclear envelope pool. J Mol Cell Cardiol. 2020;143:107-119. doi.org/10.1016/j.yjmcc.2020.04.025. PMID: 32353354.

Chen M, Xu D, Wu AZ, Kranias EK, Lin SF, Chen PS, Chen Z.  Phospholamban Regulates Nuclear Ca2+ Stores and Inositol 1,4,5-Trisphosphate Mediated Nuclear Ca2+ Cycling in Cardiomyocytes. J. Mol. Cell. Cardiol., 2018, Oct;123:185-197. PMID:30261161.  

Wu AZ, Xu D, Yang N, Lin SF, Chen PS, Cala SE, Chen Z. Phospholamban is concentrated in the nuclear envelope of cardiomyocytes and involved in perinuclear/nuclear calcium handling. J. Mol. Cell. Cardiol. 2016;100:1-8. doi: 10.1016/j.yjmcc.2016.09.008. PubMed PMID: 27642167.

Titles & Appointments

  • Associate Professor of Medicine
  • Adjunct Associate Professor of Anatomy, Cell Biology & Physiology

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