Fueled by foundational teaching and innovative research, the Disease and Therapeutic Response Modeling Program equips young scientists with diverse experiences in the design, application and interpretation of quantitative approaches that drive the evolution of medical therapies.
Disease and Therapeutic Response Modeling Program

Videos Now Available!
12th Annual Indiana CTSI Disease and Therapeutic Response Modeling Symposium: 2/22/23, Day 1, Video 1 of 212th Annual Indiana CTSI Disease and Therapeutic Response Modeling Symposium: 2/22/23, Day 1, Video 2 of 2
12th Annual Indiana CTSI Disease and Therapeutic Response Modeling Symposium; Day 2 Video 1 of 2
12th Annual Indiana CTSI Disease and Therapeutic Response Modeling Symposium; Day 2, Video 2 of 2
12th Annual Indiana CTSI Disease and Therapeutic Response Modeling Symposium; Day 3, Video 1 of 1
The DTRMP also plays a critical role in the Division of Clinical Pharmacology’s T32 Training Program, with most fellows attending didactic sessions offered on population pharmacokinetic/pharmacodynamic or physiologically based pharmacokinetic modeling, and many participating in pharmacometric-oriented research projects. Additionally, graduate students from Purdue University’s Department of Pharmacy Practice participate in the didactic sessions and are often actively mentored by DTRMP faculty.
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Director
Sara Quinney, PhD, is the current Director of the Disease and Therapeutic Response Modeling Program.
Dr. Quinney serves as a standing member of the IU Simon Comprehensive Cancer Center Cancer Drug Development Working Group, is PI for the MPRINT DMKRCC (supporting pharmacometric modeling in maternal and pediatric therapeutics) and provides support to Drug Think Tank investigators. Additionally, the DTRMP supports PK/PD study design and analyses for multiple clinical studies.
For additional information on the DTRMP program, please contact Dr. Quinney.
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Didactic CoursesIn addition to the introductory Pharmacokinetics and Pharmacodynamics course that is part of the Clinical Pharmacology T32 didactics training program, the DTRMP has developed two advanced pharmacometrics courses: Physiologically-Based Pharmacokinetics and Population Pharmacokinetics. These courses are offered every-other year. Purdue University Department of Pharmacy Practice offers credit for these courses to their graduate students. Additionally, we offer a short-course in biostatistics for clinical pharmacologists. These courses utilize experts from the pharmaceutical industry to provide fundamental knowledge of pharmacometrics as well as cutting-edge applications.
Course Name Director(s) Clinical Pharmacokinetics and Pharmacodynamics Richard Bergstrom
Sara Quinney
Brian Overholser
Kevin SowinskiPhysiologically Based Pharmacokenetic Modeling Sara Quinney Population Pharmacokinetics Michael Heathman Biostatistics for Clinical Pharmacologists Richard Bergstrom
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Annual DTRMP Symposium
The DTRMP hosts an annual symposium, featuring international experts in pharmacometrics and quantitative sciences from academia, industry, and regulatory agencies. In 2021, the symposium was held virtually over three days and included a number of interactive breakout sessions to provide networking and mentorship opportunities for trainees.
The 2022 symposium was held February 16-18, 2022. Speakers included Sander Vinks (University of Cincinnati), Christina Frederich (Rosa), Craig Goergen (Purdue University), Sebastian Wicha (University of Hamburg), Rada Savic (UCSF), Allison Hill (John Hopkins), lan Pearlson (Los Alamos Laboratories), Denise Kirschner (University of Michigan), and speakers from Eli Lilly, Abbvie, Metrum Research Group, and the FDA.
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Supporting Drug Development and Clinical StudiesThe DTRMP plays a critical collaborative role in numerous drug development and personalized therapeutics initiatives at Indiana University School of Medicine.
Services provided by the DTRMP include:
- In silico predictions; in vitro/in vivo extrapolation
- Preclinical study design – dosing, optimal sampling times
- Preclinical data assessment – bioavailability, clearance, volume, half-life
- Clinical study design – dosing, optimal sampling
- Pharmacokinetic-pharmacodynamic modeling of preclinical & clinical data
- Clinical data assessment – sources of inter-individual variability
- Noncompartmental, population and mechanistic PK/PD modeling
- MODEL-AD and TREAT-AD programs
Want to know more?
Disease and Therapeutic Response Modeling Program Fellowship