Fueled by foundational teaching and innovative research, the Indiana CTSI Pharmacometrics Modeling and Simulation (M&S) Program (formerly the Disease and Therapeutic Response Modeling Program) equips young scientists with diverse experiences in the design, application and interpretation of quantitative approaches that drive the evolution of medical therapies.
Learn more about our Annual Indiana CTSI Pharmacometrics M&S Symposium
Join us Wednesday, March 19 through Friday, March 21, 2025 for the 14th Annual Indiana CTSI Pharmacometrics M&S Symposium in Indianapolis, IN. Virtual attendance also available. Registration coming soon!
With the growth of model-informed drug discovery, the roles of quantitative pharmacologists and pharmacometricians are rapidly growing in the pharmaceutical industry. Since 2009, the Indiana CTSI Pharmacometrics M&S Program at Indiana University School of Medicine has trained over 30 postdoctoral fellows and graduate students, the majority of whom continue to play important research and leadership roles within the pharmaceutical industry.
The Indiana CTSI Pharmacometrics M&S Program also plays a critical role in the Division of Clinical Pharmacology’s T32 Training Program, with most fellows attending didactic sessions offered on population pharmacokinetic/pharmacodynamic or physiologically based pharmacokinetic modeling, and many participating in pharmacometric-oriented research projects. Additionally, graduate students from Purdue University’s Department of Pharmacy Practice participate in the didactic sessions and are often actively mentored by Indiana CTSI Pharmacometrics M&S Program faculty.
Sara Quinney, PhD, is the current director of the Indiana CTSI Pharmacometrics Modeling and Simulation Program.
Dr. Quinney serves as a standing member of the IU Simon Comprehensive Cancer Center Cancer Drug Development Working Group, is PI for the MPRINT DMKRCC (supporting pharmacometric modeling in maternal and pediatric therapeutics) and provides support to Drug Think Tank investigators. Additionally, the Indiana CTSI Pharmacometrics M&S Program supports PK/PD study design and analyses for multiple clinical studies.
For additional information on the Indiana CTSI Pharmacometrics M&S Program, please contact Dr. Quinney.
In addition to the introductory Pharmacokinetics and Pharmacodynamics course that is part of the Clinical Pharmacology T32 didactics training program, the Indiana CTSI Pharmacometrics M&S Program has developed two advanced pharmacometrics courses: Physiologically-Based Pharmacokinetics and Population Pharmacokinetics. These courses are offered every-other year. Purdue University Department of Pharmacy Practice offers credit for these courses to their graduate students. Additionally, we offer a short-course in biostatistics for clinical pharmacologists. These courses utilize experts from the pharmaceutical industry to provide fundamental knowledge of pharmacometrics as well as cutting-edge applications.
| Course Name | Director(s) |
| Clinical Pharmacokinetics and Pharmacodynamics | Richard Bergstrom Sara Quinney Brian Overholser Kevin Sowinski |
| Physiologically Based Pharmacokenetic Modeling | Sara Quinney |
| Population Pharmacokinetics | Michael Heathman |
| Biostatistics for Clinical Pharmacologists | Richard Bergstrom |
The Indiana CTSI Pharmacometrics M&S Program (formerly DTRMP) hosts an annual symposium featuring international experts in pharmacometrics and quantitative sciences from academia, industry and regulatory agencies. Learn more about our annual symposium.
The Indiana CTSI Pharmacometrics M&S Program plays a critical collaborative role in numerous drug development and personalized therapeutics initiatives at Indiana University School of Medicine.
Services provided by the Indiana CTSI Pharmacometrics M&S Program include:
