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XY, Bone Marrow/Neoplastic Blood — FISH Analysis

CPT Code(s): 88230, 88273, 88271 (x per probe)

Ordering Recommendation: Detection of patient gender in dividing or non-dividing cells. No additional specimen required in conjunction with chromosome study. Chimerism analysis using XY FISH performed to monitor engraftment of donor cells to assess graft success after bone marrow transplantation in patients transplanted with an opposite sex donor.

Synonyms: XY FISH, Bone marrow transplant

Methodology: Fluorescence in situ hybridization (FISH) analysis.

Performed: Monday through Friday

Reported: 5-7 days

Specimen Requirements

Collect: Whole blood in dark green-top sodium heparin tube.

Specimen Volume: Infants: 2-4 mL; Adults: 7-10 mL

Storage/Transport: Room temperature. Do not freeze or expose to extreme temperatures.

Unacceptable Conditions: Frozen or clotted.

Stability: Ambient: 48 hours; Frozen: Unacceptable.