UGT1A1 Genotyping by Fragment Analysis

CPT Code(s): 81350

Ordering Recommendation: Information about genotype may be used as an aid to clinicians in determining therapeutic strategy and treatment dose for therapeutics that are metabolized by UGT1A1.

Synonyms: UGT1A1, fragment analysis, irinotecan, atazanavir

Methodology: Polymerase chain reaction (PCR) and fragment analysis with capillary electrophoresis.

Performed: Weekly

Reported: 7-10 days

Collect: Preferred: Lavender (EDTA); Acceptable: Yellow (ACD Solution A or B), Green (Heparin), Saliva (Oragene collection device)

Specimen Volume: Blood: 3 mL whole blood (minimum 1 mL); Saliva: 2 mL

Storage/Transport: Refrigerated/Room temperature

Unacceptable Conditions: Grossly hemolyzed or clotted

Stability: One month refrigerated; One month frozen