CPT Code(s): 81403
Ordering Recommendation: Targeted PSEN2 sequencing is recommended for individuals with clinical symptoms of early onset Alzheimer disease, which begins before age 65, and 1) where either the familial variant is known or 2) the variant has been identified by a research protocol and needs to be confirmed in a clinical laboratory.
Synonyms: PSEN2, Presenilin 2, Alzheimer disease, early onset Alzheimer disease, dementia
Methodology: Sanger sequence analysis. The PSEN2 cDNA reference sequence used is NM_000447.3.
Performed: Monday through Friday
Reported: 14 days