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PGX Antidepressant (CYP2C19 and CYP2D6) Genotyping

CPT Code(s): 81225, 81226

Ordering Recommendation: Information about CYP2C19 and CYP2D6 genotype may be used as an aid to clinicians in determining therapeutic strategy and treatment dose for antidepressants.

Synonyms: CYP2C19, CYP2D6, antidepressants, amitriptyline, atomoxetine, codeine, nortriptyline, doxepin, paroxetine, clozapine, olanzapine, risperidone, carvediol, tetrabenazine, deutetrabenazine, eliglustat

Methodology: Real-time polymerase chain reaction (PCR) and microarray and copy number analysis

Performed: Weekly

Reported: 7-10 days

Specimen Requirements

Collect: Preferred: Lavender (EDTA); Acceptable: Yellow (ACD Solution A or B), Green (Heparin), Saliva (Oragene collection device)

Specimen Volume: Blood: 3 mL whole blood (minimum 1 mL); Saliva: 2 mL

Storage/Transport: Refrigerated/Room temperature

Unacceptable Conditions: Grossly hemolyzed or clotted

Stability: Two weeks refrigerated; One month frozen