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Microtubule Associated Protein Tau (MAPT), Targeted Variant Sequencing

CPT Code(s):  81403

Ordering Recommendation: Targeted MAPT sequencing is recommended for individuals with clinical symptoms of frontotemporal dementia and 1) where either the familial variant is known or 2) the variant has been identified by a research protocol and needs to be confirmed in a clinical laboratory.

Synonyms: MAPT, Microtubule Associated Protein Tau, Alzheimer disease, early-onset Alzheimer disease, dementia, frontotemporal dementia, Alzheimer's

Methodology: Sanger sequence analysis. The MAPT cDNA reference sequence used is NM_005910.5.

Performed: Monday through Friday

Reported: 14 days

Specimen Requirements

Collect: Preferred: whole blood in a lavender top (EDTA) tubes, cultured and uncultured cells

Specimen Volume: Blood: 3 mL whole blood (minimum 1 mL)

Storage/Transport: Refrigerated/Room temperature

Unacceptable Conditions: Grossly hemolyzed or clotted.

Stability: One month refrigerated; One month frozen