FISH Analysis (Individual probes) for Non-FFPE Hematological Disorders, Solid Tumors and Lymphoma
CPT Code(s): 88237, 88275 (x per analyses), 88271 (x per probe)
Service Code (IU Health): 53101259, 53100707, 53100640
Ordering Recommendation: Detection of known or suspected genetic abnormalities to confirm or establish patient diagnosis of tumor subtypes and prognostic grouping important for subsequent therapy. Companion testing with chromosome analysis to further delineate chromosomal abnormalities.
Synonyms: FISH, fluorescence in situ hybridization, hematopoietic malignancy, lymphoma, solid tumor, cancer
Methodology: Fluorescence in situ hybridization (FISH) analysis.
Performed: Monday through Friday
Reported: 2-3 days
List of FISH Probes: (for additional probes, contact laboratory)
Hematologic Probes:
- 1q21
- t(1;19) (PBX1/TCF3)
- 1q25.2 (ABL2)
- inv(3) (RPN1/MECOM)
- 4q12 (PDGFRA)
- t(4;14) (FGFR3/IGH)
- 5q32 (PDGFRB)
- -5/del(5q)
- t(6;9) (DEK/NUP214)
- del(6q) (6q21 (PRDM1) & 6q23.3 (MYB))
- del(7q)
- 8 centromere
- t(8;21) (RUNX1T1/RUNX1)
- 9p21 (CDKN2A)
- 9q34.1 (ABL1)
- t(9;22) [BCR/ABL1]
- 9q34.1 (ASS1)
- 11q23 (KMT2A, formerly MLL)
- 12 centromere
- 12p13 (ETV6)
- t(12;21) (ETV6/RUNX1)
- 13q14 (RB1 & D13S319)
- 14q32.3 (IGH)
- t(14;16) (IGH/MAF)
- t(15;17) (PML/RARA)
- inv(16) (CBFB)
- inv(16) (MYH11/CBFB)
- 17p13.1 (TP53)
- 17q21.1 (RARA)
- del(20q)
- X/Y
- Xp22.3/Yp11.2 (CRLF2)
Lymphoma Probes:
- 3q27 (BCL6)
- t(8;14) (MYC/IGH)
- 8q24 (MYC)
- t(11;14) (CCND1/IGH)
- t(11;18) (BIRC3/MALT1)
- t(14;18) (IGH/BCL2)
- 18q21 (MALT1)
Solid Tumor Probes:
- 2p24.1 (MYCN)
- 13q14.1 (FOXO1)
- 22q12 (EWSR1)