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<p>This weekend, April 26 and 27, Sound Medicine, the award-winning weekly radio program hosted by Barbara Lewis, focuses on gene mutations and breast cancer, diabetes in women, and optimism and the brain.</p>

This Week on Sound Medicine — April 27

Sound Medicine reporter Shia Levitt will speak with Carol Galaty, a woman who, after special testing, discovered she carried a genetic mutation linked to an elevated risk for breast and ovarian cancer . She also will address the impact of this risk on her daughters’ lives.

Ann Goebel-Fabbri, Ph.D., an instructor of psychiatry at Harvard Medical School and investigator in behavioral and mental health at Joslin Diabetes Center, will talk about diabulimia, where women with type 1 diabetes deliberately take less insulin than prescribed. A new study found these women had a three-fold increased risk of death and higher rates of disease complications and also exhibited eating disorder symptoms and behaviors .

Why do some people anticipate the worst while others have an optimistic outlook? A new study has identified a small part of the mid-brain, the rostral anterior cingulate cortex (rACC), as the area responsible for optimism. Cognitive neuroscientist Elizabeth Phelps, Ph.D., of New York University and co-author of the study, will discuss the findings.

Also, Allen Zadoff, a writer and teacher in L.A., will discuss his book “Hungry: Lessons Learned on a Journey From Fat to Thin,” a memoir about recognizing his food addiction, changing his eating habits and how he continues to maintain a healthy weight.

Archived editions of Sound Medicine as well as other helpful information can be found at

Sound Medicine is underwritten by the Lilly Center for Medical Science, Clarian Health, and IU Medical Group; Jeremy Shere’s “Check-Up” is underwritten by IUPUI.