Showing results for Research Findings

Researchers discover improved treatment for children with sickle cell anemia

A team of international researchers has learned that dose escalation of hydroxyurea treatment for children in Uganda with sickle cell anemia is more effective and has similar side effects than a lower fixed dose of the same drug. The study, known as NOHARM MTD (Novel use Of Hydroxyurea in an African Region with Malaria – Maximum Tolerated Dose), focused on children in Uganda, but the results could impact use of hydroxyurea worldwide, including the United States and Europe. The findings are being published in the June 25 issue of the New England Journal of Medicine.

IU School of Medicine | Jun 25, 2020

IU researchers model human stem cells to identify degeneration in glaucoma

INDIANAPOLIS — More than 3 million Americans have glaucoma, a serious eye condition causing vision loss. Using human stem cell models, researchers at Indiana University School of Medicine found they could analyze deficits within cells damaged by glaucoma, with the potential to use this information to develop new strategies to slow the disease process.

IU School of Medicine | Jun 11, 2020

Researchers grow hairy skin from human stem cells

Building on years of groundbreaking discoveries in stem cell research, scientists from Indiana University School of Medicine and Harvard Medical School have determined how to grow hairy skin using human stem cells—developing one of the most complex skin models in the world. The study, published June 3 in Nature, shows that skin generated from pluripotent stem cells can be successfully grafted on a nude mouse to grow human skin and hair follicles. That discovery could lead to future studies in skin reconstruction, disease modeling and treatment.

IU School of Medicine | Jun 04, 2020

IU study tracks COVID-19 spread in pediatric dialysis unit

As COVID-19 continues its sweep around the globe, dialysis units have continued to be hotspots for the virus’ spread. Researchers at Indiana University School of Medicine hope to combat that threat, through a novel study published May 14, 2020 in JAMA.

IU School of Medicine | May 14, 2020

headshots of xiongbin lu and sophie paczesny

Cancer center researchers identify checkpoint target for colorectal cancer immunotherapy

Researchers at the Indiana University Melvin and Bren Simon Comprehensive Cancer Center have identified a target for colorectal cancer immunotherapy.

IU School of Medicine | May 07, 2020

Types of vitamin E consumed by children linked to lung function

What we feed our young children—including certain baby formulas—could be interfering with the healthy development of their lungs. Researchers examined the effects of different forms of vitamin E on lung development during early childhood. They found that too much of one form could be detrimental to growing children.

IU School of Medicine | Apr 27, 2020

First study assessing active COVID-19 in asymptomatic people launched by IU School of Medicine

Indiana University School of Medicine researchers are launching a community-based study today to find out how many people in Marion County who aren’t currently showing symptoms have COVID-19.

IU School of Medicine | Apr 23, 2020

a graphic shows the flow of energy to boost recovery in spinal nerve damage

Boosting recovery: Scientists study link between energy levels, spinal cord injury

INDIANAPOLIS—Each year, thousands of people in the United States experience a spinal cord injury, damaging the system of nerves that the brain and body use to communicate. A team of researchers from Indiana University School of Medicine, in collaboration with the National Institute of Neurological Disorders and Stroke, have investigated how boosting energy levels within […]

IU School of Medicine | Mar 03, 2020

Indiana University School of Medicine researchers discover emerging combination therapy that halts tumor growth based on Tyler Trent’s cell lines

INDIANAPOLIS – Researchers at Indiana University School of Medicine have found a combination therapy that significantly slows tumor growth in models, built from cells taken from Tyler Trent’s tumors. Tyler was a Purdue University student and football superfan who died on January 1, 2019, after waging a long and valiant fight against an aggressive form […]

IU School of Medicine | Jan 16, 2020

First randomized clinical trial found no harms from dementia screening in primary care

INDIANAPOLIS – Research scientists at Regenstrief Institute and Indiana University School of Medicine have conducted the first randomized controlled trial to evaluate the pros and cons of population screening for dementia. The researchers found no harm, as measured by patient reported depressive and anxiety symptoms, from screening for Alzheimer’s disease and related dementia in diverse […]

IU School of Medicine | Jan 15, 2020