Worldwide, 1 in 4 people will suffer from a depressive episode in their lifetime. While current diagnosis and treatment approaches are largely trial and error, a breakthrough study by Indiana University School of Medicine researchers sheds new light on the biological basis of mood disorders, and offers a promising blood test aimed at a precision medicine approach to treatment.
Researchers at Indiana University School of Medicine have successfully reprogrammed a glial cell type in the central nervous system into new neurons to promote recovery after spinal cord injury—revealing an untapped potential to leverage the cell for regenerative medicine.
For years, scientists have observed that women with pulmonary hypertension have better survival rates than men with the same condition. It wasn’t clear exactly why this is true—until now. Indiana University School of Medicine researchers studying a type of pulmonary hypertension called pulmonary arterial hypertension (PAH) found that estrogen, its receptor ER-α, and a protein called BMPR2 work together to increase an abundance of another protein called apelin, which exerts a protective effect on the right heart.
Researchers from Indiana University have identified key genetic changes in the interstitial kidney tissue of people with diabetes, a discovery that signifies the potential for a revolutionary new genetic approach to the treatment of kidney disease.
Researchers at the Indiana University Melvin and Bren Simon Comprehensive Cancer Center have identified how breast cancer cells hide from immune cells to stay alive. The discovery could lead to better immunotherapy treatment for patients.
Researchers are learning more about ways to predict the likelihood of newborn complications from early in pregnancy using samples provided by the Indiana University School of Medicine Building Blocks of Pregnancy Biobank.
A group of researchers including Chandy John, MD, from Indiana University School of Medicine, published a study in the New England Journal of Medicine showing malaria chemoprevention reduces morbidity and mortality in children with severe anemia.
Researchers at Indiana University School of Medicine have published their work about a specific type of childhood cancer in the peer-reviewed, international oncology journal, Cancers. This research involves a combination therapy that significantly slows tumor growth in models, which includes a model established from cells taken from tumors donated by Tyler Trent.