Showing results for Research Findings

B cell activating factor could hold key to immune tolerance for hemophilia, study finds

A group of scientists have just made a key discovery that could prevent and eradicate immune responses that lead to treatment failure in about one-third of people with severe hemophilia A.

IU School of Medicine | Apr 15, 2021

Niculescu biomarkers blood test mood disorders

IU School of Medicine researchers develop blood test for depression, bipolar disorder

Worldwide, 1 in 4 people will suffer from a depressive episode in their lifetime. While current diagnosis and treatment approaches are largely trial and error, a breakthrough study by Indiana University School of Medicine researchers sheds new light on the biological basis of mood disorders, and offers a promising blood test aimed at a precision medicine approach to treatment.

IU School of Medicine | Apr 07, 2021

spinal cord injury stark neuroscience research institute

IU School of Medicine researchers discover new potential for functional recovery after spinal cord injury

Researchers at Indiana University School of Medicine have successfully reprogrammed a glial cell type in the central nervous system into new neurons to promote recovery after spinal cord injury—revealing an untapped potential to leverage the cell for regenerative medicine.

IU School of Medicine | Mar 05, 2021

Unexpected protein key to estrogen’s protective effect on right heart function, IU researchers find

For years, scientists have observed that women with pulmonary hypertension have better survival rates than men with the same condition. It wasn’t clear exactly why this is true—until now. Indiana University School of Medicine researchers studying a type of pulmonary hypertension called pulmonary arterial hypertension (PAH) found that estrogen, its receptor ER-α, and a protein called BMPR2 work together to increase an abundance of another protein called apelin, which exerts a protective effect on the right heart.

IU School of Medicine | Feb 25, 2021

IU School of Medicine researchers discover gamechanger combination drug for triple negative breast cancer

A team of Indiana University School of Medicine researchers has developed a novel antibody-drug conjugate for treating triple negative breast cancer.

IU School of Medicine | Feb 23, 2021

IU School of Medicine researchers identify disease-related gene changes in kidney tissue

Researchers from Indiana University have identified key genetic changes in the interstitial kidney tissue of people with diabetes, a discovery that signifies the potential for a revolutionary new genetic approach to the treatment of kidney disease.

IU School of Medicine | Feb 16, 2021

IU cancer center researchers discover how breast cancer cells hide from immune attack

Researchers at the Indiana University Melvin and Bren Simon Comprehensive Cancer Center have identified how breast cancer cells hide from immune cells to stay alive. The discovery could lead to better immunotherapy treatment for patients.

IU School of Medicine | Jan 26, 2021

Researchers learn to predict very preterm birth, neonatal complications in early pregnancy

Researchers are learning more about ways to predict the likelihood of newborn complications from early in pregnancy using samples provided by the Indiana University School of Medicine Building Blocks of Pregnancy Biobank.

IU School of Medicine | Jan 07, 2021

Chandy John malaria New England Journal of Medicine

Malaria chemoprevention reduces disease and death in children after being hospitalized for severe anemia

A group of researchers including Chandy John, MD, from Indiana University School of Medicine, published a study in the New England Journal of Medicine showing malaria chemoprevention reduces morbidity and mortality in children with severe anemia.

IU School of Medicine | Dec 02, 2020

IU School of Medicine researchers publish first scientific article dedicated to Tyler Trent’s donated tumors, his legacy

Researchers at Indiana University School of Medicine have published their work about a specific type of childhood cancer in the peer-reviewed, international oncology journal, Cancers. This research involves a combination therapy that significantly slows tumor growth in models, which includes a model established from cells taken from tumors donated by Tyler Trent.

IU School of Medicine | Dec 01, 2020