Showing results for Research Findings

IU researchers develop new brain network modeling tools to advance Alzheimer's disease research

Indiana University researchers are collaborating on a novel approach to use neuroimaging and network modeling tools—previously developed to analyze brains of patients in the clinic—to investigate Alzheimer’s disease progression in preclinical animal models.

IU School of Medicine | Nov 30, 2023

IU South Bend. | Photo by James Brosher, Indiana University

New target identified for pulmonary hypertension treatment

Indiana University School of Medicine researchers at the school’s South Bend regional campus, in collaboration with colleagues at the University of Notre Dame, have identified a new therapeutic target for pulmonary hypertension, a type of high blood pressure that affects the blood vessels in the lungs. Their findings were recently published in Circulation Research.

IU School of Medicine | Nov 17, 2023

Repurposed drug offers new potential for managing type 1 diabetes

A recent study led by Indiana University School of Medicine in collaboration with the University of Chicago Medicine presents exciting future possibilities for the management of type 1 diabetes and the potential reduction of insulin dependency.

IU School of Medicine | Nov 01, 2023

KCVRC investigators review a heart image.

First ever clinical classification of heart attacks based on tissue damage adopted by Canadian Cardiovascular Society

The Canadian Cardiovascular Society (CCS) released the world’s first classification of acute myocardial infarction (AMI) — or heart attack — based on heart tissue damage research that was driven by two cardiovascular investigators within the Ischemic Heart Disease Program of Krannert Cardiovascular Research Center (KCVRC) at Indiana University School of Medicine and Northern Ontario School of Medicine.

IU School of Medicine | Oct 29, 2023

Nathan Schmidt wears a white lab coat and stands next to instrumentation in his lab

Specific gut bacteria increase risk of severe malaria

Indiana University School of Medicine researchers have identified multiple species of bacteria that, when present in the gut, are linked to an increased risk of developing severe malaria in humans and mice.

IU School of Medicine | Oct 27, 2023

Harikrishna Nakshatri, PhD IU Simon Cancer Center

IU cancer center researchers identify biology behind aggressive breast cancers in Black women

Researchers at Indiana University Melvin and Bren Simon Comprehensive Cancer Center are unlocking the biology behind aggressive breast cancers in Black women.

IU Simon Comprehensive Cancer Center | Oct 25, 2023

a close up photo of gloved hands preparing a sample in the lab

IU researchers identify new gene mutation that alters Alzheimer’s disease risk

A groundbreaking study led by experts from Indiana University School of Medicine has shed new light on the genetic underpinnings of Alzheimer's disease.

IU School of Medicine | Sep 06, 2023

Study: health equity an important aspect of improving quality of care provided to children in emergency departments

A new multi-site study led by Indiana University School of Medicine found increasing pediatric readiness in emergency departments reduces, but does not eliminate, racial and ethnic disparities in children and adolescents with acute medical emergencies.

IU School of Medicine | Sep 05, 2023

Overlooked part of brain could play critical role in addiction recovery

Researchers from Indiana University School of Medicine have discovered a neglected brain region that could play a critical role in how likely a person with drug use disorders is to relapse, even after a long withdrawal period. Their findings were published recently in Biological Psychiatry.

IU School of Medicine | Aug 24, 2023

Tau protein in Alzheimer's disease, illustration. The insets show two ways in which pathological phosphorylation (yellow) of Tau proteins (red-orange) by kinases (blue-purple) affect nerve cells in what is called a neurofibrillary tangle. The main illustration showing a nerve cell (neuron, blue, lower left) and its axon (across bottom), shown in a misshapen and abnormal state. Pathological aggregations of tau proteins cause disintegration of microtubules (inset at left). The transport of synaptic vesicles (orange-blue spheres, inset at right) is also interrupted. A neurofibrillary tangle consists of abnormal aggregates and insoluble fibres of the protein tau. Tau protein is an abundant neural protein, aggregations of which are thought to play a role in Alzheimer's disease and other neural disorders.

Neuroscientists create new resource to improve Alzheimer’s disease research models

Genetic diversity key to new study on abnormal protein accumulation in the brain—a hallmark of Alzheimer’s disease development

IU School of Medicine | Aug 22, 2023