A team of international researchers has learned that dose escalation of hydroxyurea treatment for children in Uganda with sickle cell anemia is more effective and has similar side effects than a lower fixed dose of the same drug. The study, known as NOHARM MTD (Novel use Of Hydroxyurea in an African Region with Malaria – Maximum Tolerated Dose), focused on children in Uganda, but the results could impact use of hydroxyurea worldwide, including the United States and Europe. The findings are being published in the June 25 issue of the New England Journal of Medicine.
INDIANAPOLIS — Adrian Gardner, MD, MPH, a global health leader who spent the last seven years in Kenya as part of the Indiana University School of Medicine-led AMPATH program, has been named the school’s associate dean for global health. He will also serve as director of the IU Center for Global Health, an umbrella institute […]
Earlier this year, researchers determined that a common complication for children recovering from severe malaria is linked to long-term cognitive impairment. Now, they’ve worked to define how those impairments translate to behavioral outcomes for the thousands of children affected—especially in sub-Saharan Africa, where they are at high risk for parasite exposure. In a study published […]
Malaria continues to be a major threat to public health for much of the world’s population. In 2017, more than 400,000 malaria-related deaths were reported globally, and over 90 percent were in sub-Saharan Africa. Almost two-thirds of the deaths were in children. The most severe and deadliest form of the parasitic disease is cerebral malaria, […]
More than 200 million children around the world are at risk of failing to meet their developmental potential, and the risk is highest for children in sub-Saharan Africa. In that part of the world, severe malaria is a leading cause of acquired neurodisability—leaving many children with developmental delay even years after recovery. Scientists don’t fully […]
Hands-on global health opportunities and challenges await four first-year IU School of Medicine students selected to travel to the AMPATH program in western Kenya this summer. Students Sean Buehler, Michael Harding, Bilal Jawed and Grace Rushton form this year’s class of student ambassadors, called Slemenda Scholars, who will learn about every facet of AMPATH’s programs […]
During more than a dozen visits over the last 24 years, Stephanie and Craig Brater have witnessed the transformative development of the health care system in western Kenya and that experience will fuel more global health advances as they assume leadership of the Indiana University Center for Global Health development board. Established in 2010, the […]
Indiana University School of Medicine researchers have identified a way to block the ability of parasites that cause malaria to shield themselves against drug treatments in infected mice—a finding that could lead to the development of new approaches to combat this deadly disease in humans.
The drug hydroxyurea does not appear to increase the risk of malaria infection in patients with sickle cell anemia who live in malaria-endemic regions, according to a study published online today in Blood, a Journal of the American Society of Hematology (ASH).
African American women participating in a clinical study on breast cancer had more side effects and poorer survival rates than did women of European ancestry, according to a recently published Indiana University study that identified ethnicity through genetics, a first in this type of research.