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Faculty

22059-Capitano, Maegan

Maegan L. Capitano, PhD

Assistant Professor of Microbiology & Immunology

Extrinsic regulation of hematopoiesis

The laboratory’s research emphasis is to study novel agents that regulate hematopoietic stem/progenitor cell migration, proliferation, differentiation, and survival capacity under normal and stressed conditions and to study how these agents can be used to improve both mouse and human donor hematopoietic stem/progenitor cell engraftment following transplantation in animal models.

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9949-Clapp, D.

D. W. Clapp, MD

Chair, Department of Pediatrics

Molecular pathogenesis of Fanconi anemia & neurofribromatosis

My laboratory focuses on understanding the molecular pathogenesis of NF1 and particularly the role of immune cells in tumor initiation and progression. We utilize a combined approach of using GEMMs and bone marrow transplantation to identify molecular and pharmacologic targets to treat the benign tumors in mice and in humans.

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6485-Cornetta, Kenneth

Kenneth G. Cornetta, MD

Professor of Clinical Medical & Molecular Genetics

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20826-Dahl, Richard

Richard Dahl, PhD

Associate Professor of Microbiology & Immunology

Gene regulation programming hematopoietic development

The Dahl Laboratory investigates how transcription factors and miRNAs program the maintenance and differentiation of adult hematopoietic stem and progenitor cells and how these normal programs are disrupted in hematopoietic diseases.

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26940-Dave, Utpal

Utpal Dave, MD

Associate Professor of Medicine

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15118-Dent, Alexander

Alexander L. Dent, PhD

Professor of Microbiology & Immunology

Regulation of the antibody response by T cells

My lab studies the regulation of the antibody response, and specifically the T helper cells that are required for helping B cells. Our work has implications for controlling allergic disease and autoimmune disease, and also for helping to develop vaccines that can target infectious diseases and cancer cells.

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5023-Dunn, Kenneth

Kenneth W. Dunn, PhD

Professor of Medicine

Kidney microtubules function in diabetic patients

Development and implementation of methods of quantitative fluorescence microscopy, intravital microscopy studies of the function of the liver and kidney in health and disease.

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5074-Farag, Sherif

Sherif S. Farag, PhD, MB,BS, FRACP, FRCPA

Kenneth Wiseman Professor of Medicine

Cord blood and marrow HSC transplantation. NK cell function in transplant recipients

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41867-Herzog, Roland

Roland W. Herzog, PhD

Riley Children's Foundation Professor of Immunology

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Aki Hoji, PhD

Assistant Research Professor of Pediatrics

Bioactive Lipids regulation of HSC self-renewal and lineage differentiation and development of the in vitro 3D human BM bioprinting system

Overreaching aims of current projects are to: 1) characterize effects of bioactive lipids on LTHSC self-renewal in vivo, and 2) establish in vitro 3D biopriting assay system l of human LTHSC as a model for in vivo effects of bioactive lipids.

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18628-Kacena, Melissa

Melissa A. Kacena, PhD, MS, BS

Professor of Orthopaedic Surgery

Role of osteoblasts in hematopoietic niche. Impact of megakaryocytes on osteogenesis

Our research focuses on the regulatory interactions between skeletal and hematopoietic cells in 3 main areas: 1) The effects of megakaryocytes on osteoblast proliferation and bone formation; 2) The regulation of bone regeneration by thrombopoietin; and 3) The regulation of hematopoietic stem cells by osteoblasts, megkaryocytes, and osteal macrophages.

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906-Kaplan, Mark

Mark H. Kaplan, PhD

Chair, Department of Microbiology & Immunology

Cytokine and cellular control of inflammation

Research in the Kaplan lab focuses on understanding communication between cells during inflammatory diseases including allergy, asthma, and autoimmune disease. Studies explore the development of cytokine-producing T cells, how T cell-proudced cytokines impact mast cells and macrophage homeostasism and transcriptoin factors important in these cells that control effector function.

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13517-Kapur, Reuben

Reuben Kapur, PhD

Director, Herman B Wells Center for Pediatric Research

Molecular mechanisms involved in normal and abnormal hematopoiesis

We study signaling pathways involved in regulating normal hematopoiesis as well as non-malignant hematologic diseases. Specifically, we study how PI3Kinase and Rho family GTPases ROCK and Rap1 contribute to stem and progenitor cell functions. We also study the role of stress MAPKinase pathways in normal and stress hematopoiesis.

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4819-Orschell, Christie

Christie M. Orschell, PhD

Robert Wallace Miller Professor of Oncology

Radiation effects on hematopoiesis, hematopoietic reconstitution, and hematopoietic stem cell biology

Dr. Orschell is a radiobiologist/experimental hematologist focused on understanding mechanisms of radiation damage to normal tissue and developing protection and mitigation strategies to overcome this damage and enhance recovery/survival from the hematopoietic acute radiation syndrome and the delayed effects of acute radiation exposure.

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23630-Patterson, Andrea

Andrea M. Patterson, PhD

Assistant Research Professor of Medicine

HSC radiobiology and aging

Our research is focused on defining functional and molecular mechanisms by which bioactive lipids and cytokines affect HSCs under stress for development of novel therapeutic agents for radiation- and aging-induced HSC dysfunction.

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13373-Pelus, Louis

Louis M. Pelus, PhD

Senior Research Professor of Medicine

Bioactive cytokines/growth factor control of HSC proliferation & migration

Our research focuses on hematopoietic stem cell self-renewal, differentiation and regeneration. We study how these processes are normally regulated by intrinsic and extrinsic mechanisms or altered under stress such as aging and radiation exposure.   

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44428-Perna, Fabiana

Fabiana Perna, PhD, MD

Associate Professor of Medicine

The cell surface proteome of hematologic malignancies for immune targeting

The Perna lab investigates how essential genetic and epigenetic determinants of hematologic malignancies shape the cell surface proteome, thus providing targets for promoting leukemogenesis and use of precision immunotherapy. We develop innovative proteogenomic approaches for cell surface target discovery. 

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13544-Pollok, Karen

Karen E. Pollok, PhD

Associate Professor of Pediatrics

Immunotherapy and DNA repair

Our research on normal hematopoiesis is to discover mechanistically how human hematopoietic cells respond to genotoxic stress. We are using ex-vivo expanded myeloid precursor cells and humanized bone marrow mouse models to interrogate molecular mechanisms and develop strategies to protect these life-sustaining cells from the deleterious effects of genotoxic stress.

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17632-Ramdas, Baskar

Baskar Ramdas, PhD, MSC

Assistant Research Professor of Pediatrics

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Martin J. Richer, PhD

Associate Professor of Microbiology & Immunology

How host-pathogen interaction shape the immune response

The Richer laboratory is interested in understanding the regulation of T cell function in health and disease using viral models of infection.

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16603-Singh, Pratibha

Pratibha Singh, PhD, MSC

Assistant Research Professor of Medicine

The role of bone marrow microenvironment in hematopoiesis

My research focuses on understanding mechanisms/factors that regulate stem cell homeostasis and deciphering specific changes in stem cells and their niches under stress/pathologic conditions such as myeloablation, aging, and diabetes. I am particularly interested in exploring the roles of neuronal signals in hematopoietic stem cell niche regulation.

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photo of edward srour

Edward F. Srour, PhD, MS

Robert J. and Annie S. Rohn Professor of Leukemia Research

Hematopoietic microenvironment; cell cycle regulation and engraftment of HSC

The Srour research focuses on the impact of interactions between hematopoietic stem cells (HSC) and cellular elements of the hematopoietic niche on the maintenance and function of HSC. This research centers on how osteoblasts, osteomacs, and megakaryocytes maintain the stem cell pool and how CD166 bridges these cells together. 

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59861-Tran, Ngoc Tung

Ngoc Tung Tran, PhD

Assistant Professor of Pediatrics

Gene Editing in Hematopoietic Stem Cells, Monogenic Diseases, Multiple Myeloma

My research interest is to utilize gene editing tools to understand disease mechanisms and develop therapeutic approaches for blood disorders. The current lab research focus are (1) developing the CRISPR/Cas9-based gene therapy for Fanconi Anemia and (2) targeting N-link glycosylation for treatment of multiple myeloma.

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39166-Yang, Kai

Kai Yang, PhD

Assistant Professor of Pediatrics

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38080-Zhang, Ji

Ji Zhang, PhD

Assistant Professor of Pediatrics

Metabolic regulation of hematopoiesis

The Zhang lab combines biochemical, molecular/cellular and mouse genetic approaches to elucidate the role of asparagine metabolism in (1) normal HSC function during hematopoietic reconstitution and (2) B cell activation/differentiation in response to antigen stimulation. 

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