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Utpal Dave, MD
Utpal Dave, MD
Associate Professor of Medicine
Titles & Appointments
Associate Professor of Medicine
Associate Professor of Microbiology & Immunology
LDB1 Enforces Stability on Direct and Indirect Oncoprotein Partners in Leukemia.
Layer JH; Christy M; Placek L; Unutmaz D; Guo Y; Davé UP; Molecular and cellular biology 2020 Mar 30
Ldb1 is required for Lmo2 oncogene-induced thymocyte self-renewal and T-cell Acute Lymphoblastic Leukemia.
Li L; Mitra A; Cui K; Zhao B; Choi S; Lee J; Stamos DB; El-Khoury D; Warzecha C; Pfeifer K; Hardwick J; Zhao K; Venters B; Dave UP; Love PE; 2020 Mar 16
Genomic Profiling of T-Cell Neoplasms Reveals Frequent <i>JAK1</i> and <i>JAK3</i> Mutations With Clonal Evasion From Targeted Therapies.
Greenplate A; Wang K; Tripathi RM; Palma N; Ali SM; Stephens PJ; Miller VA; Shyr Y; Guo Y; Reddy NM; Kozhaya L; Unutmaz D; Chen X; Irish JM; Davé UP; JCO precision oncology 2018 Feb 13
PI3K?/d and NOTCH1 Cross-Regulate Pathways That Define the T-cell Acute Lymphoblastic Leukemia Disease Signature.
Efimenko E; Davé UP; Lebedeva IV; Shen Y; Sanchez-Quintero MJ; Diolaiti D; Kung A; Lannutti BJ; Chen J; Realubit R; Niatsetskaya Z; Ten V; Karan C; Chen X; Califano A; Diacovo TG; Molecular cancer therapeutics 2017 Jul 17
Myeloid translocation genes differentially regulate colorectal cancer programs.
Parang B; Bradley AM; Mittal MK; Short SP; Thompson JJ; Barrett CW; Naik RD; Bilotta AJ; Washington MK; Revetta FL; Smith JJ; Chen X; Wilson KT; Hiebert SW; Williams CS; Oncogene 2016 Jun 6
Endogenous dendritic cells from the tumor microenvironment support T-ALL growth via IGF1R activation.
Triplett TA; Cardenas KT; Lancaster JN; Hu Z; Selden HJ; Jasso GJ; Balasubramanyam S; Chan K; Li L; Chen X; Marcogliese AN; Davé UP; Love PE; Ehrlich LI; Proceedings of the National Academy of Sciences of the United States of America 2016 Feb 9
LMO2 Oncoprotein Stability in T-Cell Leukemia Requires Direct LDB1 Binding.
Layer JH; Alford CE; McDonald WH; Davé UP; Molecular and cellular biology 2015 Nov 23
Hhex is Required at Multiple Stages of Adult Hematopoietic Stem and Progenitor Cell Differentiation.
Goodings C; Smith E; Mathias E; Elliott N; Cleveland SM; Tripathi RM; Layer JH; Chen X; Guo Y; Shyr Y; Hamid R; Du Y; Davé UP; Stem cells (Dayton, Ohio) 2015 May 27
Whole-genome sequencing reveals oncogenic mutations in mycosis fungoides.
McGirt LY; Jia P; Baerenwald DA; Duszynski RJ; Dahlman KB; Zic JA; Zwerner JP; Hucks D; Dave U; Zhao Z; Eischen CM; Blood 2015 Jun 16
LMO2 induces T-cell leukemia with epigenetic deregulation of CD4.
Cleveland SM; Goodings C; Tripathi RM; Elliott N; Thompson MA; Guo Y; Shyr Y; Davé UP; Experimental hematology 2014 May 2
LIM domain only-2 (LMO2) induces T-cell leukemia by two distinct pathways.
Smith S; Tripathi R; Goodings C; Cleveland S; Mathias E; Hardaway JA; Elliott N; Yi Y; Chen X; Downing J; Mullighan C; Swing DA; Tessarollo L; Li L; Love P; Jenkins NA; Copeland NG; Thompson MA; Du Y; Davé UP; PloS one 2014 Jan 21
Tgif1 regulates quiescence and self-renewal of hematopoietic stem cells.
Yan L; Womack B; Wotton D; Guo Y; Shyr Y; Davé U; Li C; Hiebert S; Brandt S; Hamid R; Molecular and cellular biology 2013 Oct 7
Lmo2 induces hematopoietic stem cell-like features in T-cell progenitor cells prior to leukemia.
Cleveland SM; Smith S; Tripathi R; Mathias EM; Goodings C; Elliott N; Peng D; El-Rifai W; Yi D; Chen X; Li L; Mullighan C; Downing JR; Love P; Davé UP; Stem cells (Dayton, Ohio) 2013 May
Targeting nonclassical oncogenes for therapy in T-ALL.
Subramaniam PS; Whye DW; Efimenko E; Chen J; Tosello V; De Keersmaecker K; Kashishian A; Thompson MA; Castillo M; Cordon-Cardo C; Davé UP; Ferrando A; Lannutti BJ; Diacovo TG; Cancer cell 2012 Apr 17
Systematic screen for tyrosine kinase rearrangements identifies a novel C6orf204-PDGFRB fusion in a patient with recurrent T-ALL and an associated myeloproliferative neoplasm.
Chmielecki J; Peifer M; Viale A; Hutchinson K; Giltnane J; Socci ND; Hollis CJ; Dean RS; Yenamandra A; Jagasia M; Kim AS; Davé UP; Thomas RK; Pao W; Genes, chromosomes & cancer 2011 Sep 21
FERM domain mutations induce gain of function in JAK3 in adult T-cell leukemia/lymphoma.
Elliott NE; Cleveland SM; Grann V; Janik J; Waldmann TA; Davé UP; Blood 2011 Aug 5
Sox4 cooperates with PU.1 haploinsufficiency in murine myeloid leukemia.
Aue G; Du Y; Cleveland SM; Smith SB; Davé UP; Liu D; Weniger MA; Metais JY; Jenkins NA; Copeland NG; Dunbar CE; Blood 2011 Aug 30
Endoscopic ultrasound does not accurately stage early adenocarcinoma or high-grade dysplasia of the esophagus.
Young PE; Gentry AB; Acosta RD; Greenwald BD; Riddle M; Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association 2010 Sep 8
A role for proapoptotic Bax and Bak in T-cell differentiation and transformation.
Biswas S; Shi Q; Matise L; Cleveland S; Dave U; Zinkel S; Blood 2010 Sep 2
Murine leukemias with retroviral insertions at Lmo2 are predictive of the leukemias induced in SCID-X1 patients following retroviral gene therapy.
Davé UP; Akagi K; Tripathi R; Cleveland SM; Thompson MA; Yi M; Stephens R; Downing JR; Jenkins NA; Copeland NG; PLoS genetics 2009 May 22
Second-site cleavage in sterol regulatory element-binding protein occurs at transmembrane junction as determined by cysteine panning.
Duncan EA; Davé UP; Sakai J; Goldstein JL; Brown MS; The Journal of biological chemistry 1998 Jul 10
Synergistic regulation of human beta-globin gene switching by locus control region elements HS3 and HS4.
Bungert J; Davé U; Lim KC; Lieuw KH; Shavit JA; Liu Q; Engel JD; Genes & development 1995 Dec 15
Faculty research at IU School of Medicine is transforming health. Details about the medical research being conducted in faculty labs throughout IU School of Medicine are available in the Research section of this site.