Publications

Selected CCEH Member Publications (from January 2021 through April 2022). Names of CCEH members are bolded.

  1. Xu C, Fu Y, Liu S, Trittipo J, Lu X, Qi R, Du H, Yan C, Zhang C, Wan J, Kaplan MH, Yang K. (2021) BATF Regulates T regulatory cell functional specification and fitness of triglyceride metabolism in restraining allergic responses. J. Immunol. 206 (9):2088-2100.
  2. Mehrpouya-Bahrami P, Moriarty A, de Melo P, Keeter WC, Alakhras N, Nelson AS, Hoover M, Barrios M, Nadler JL, Serezani H, Kaplan MH, Galkina EV. (2021) STAT4 is expressed in neutrophils and promotes antimicrobial immunity. JCI Insight. 6(14):141326.
  3. Khan, IM, Ulrich BJ, Nelson AS, Sehra S, Kansas GS, Kaplan MH (2021) Selectin-dependence of allergic skin inflammation is diminished by maternal atopy. ImmunoHorizons. 5: 703–710.    
  4. AM Patterson, T Wu, HL Chua, CH Sampson, A Fisher, P Singh, TA Guise, H Feng, J Muldoon, L Wright, PA Plett, LM Pelus, and CM Orschell. Optimization and Profiling of Prostaglandin E2 as a Medical Countermeasure for the Hematopoietic Acute Radiation Syndrome. Radiation Res. 195(2):115-127, Feb 2021. PMID: 33302300
  5. AM Patterson, R Sellamuthu, PA Plett, CH Sampson, HL Chua, A Fisher, S Vemula, H Feng, BP Katz, G Tudor, SJ Miller, TJ MacVittie, C Booth, and CM Orschell. Establishing Pediatric Mouse Models of the Hematopoietic Acute Radiation Syndrome and the Delayed Effects of Acute Radiation Exposure. Radiation Research. 2021 Apr 1;195(4):307-323. doi: 10.1667/RADE-20-00259.1. PMID: 33577641.
  6. AM Patterson, PA Plett, CH Sampson, E Simpson, Y Liu, LM Pelus, and CM Orschell. Prostaglandin E2 Enhances Aged Hematopoietic Stem Cell Function. Stem Cells Reviews and Reports. 2021 May. DOI:10.1007/s12015-021-10177-z.
  7. Naidu SR*, Capitano M*, Ropa J*, Cooper S, Huang X, Broxmeyer HE. Chromatin remodeling subunit BRM and valine regulate hematopoietic stem/progenitor cell function and self-renewal via intrinsic and extrinsic effects. Leukemia. 2022 Mar;36(3):821-833. doi: 10.1038/s41375-021-01426-8. Epub 2021 Oct 1. PMID: 34599272. *, Co-first authors.
  8. Chen, Y., Fang, S., Ding, Q., Jiang, Q., He, J., Wang, Q., Jin, Y., Huang, X., Liu, S., Capitano, M. L., Trinh, T., Teng, Y., Meng, Q., Wan, J., Broxmeyer, H. E., & Guo, B. (2021) ADGRG1 enriches for functional human hematopoietic stem cells following ex vivo expansion-induced mitochondrial oxidative stress. Journal of Clinical Investigation. 131(20):e148329. PMCID: PMC8516455 (available on 2022-01-15)
  9. Capitano, M. L., Jaiswal, A., Broxmeyer, H. E., Pride, Y., Glover, S., Amlashi, F. G., Srinivasan, G., Williamson, E. A., Mais, D., & Hromas, R. (2021) A humanized monoclonal antibody against the endothelial chemokine CCL21 for the diagnosis and treatment of inflammatory bowel disease. PLoS One. 16(7): e0252805. PMID: 34197491.
  10. Noonan, M. L., Ni, P., Agoro, R., Sacks, S. A., Swallow, E. A., Wheeler, J. A., Clinkenbeard, E. L., Capitano, M. L., Prideaux, M., Atkins, G. J., Thompson, W. R., Allen, M. R., Broxmeyer, H. E., & White, K. E. (2021) The HIF-PHI BAY 85-3934 (Molidustat) Improves Anemia and Is Associated With Reduced Levels of Circulating FGF23 in a CKD Mouse Model. Journal of Bone and Mineral Research. 36(6): 117-1130. PMID: 33592127.
  11. Capitano, M. L.*, Mohamad, S. F., Cooper, S., Guo, B., Huang, X., Gunawan, A. M., Sampson, C., Ropa, J., Srour, E. F., Orschell, C. M., & Broxmeyer, H. E.* (2021) Mitigating oxygen stress enhances aged mouse hematopoietic stem cell numbers and function. Journal of Clinical Investigation. 131(1): e140177. PMCID: PMC7773345 *, Co-Corresponding Authors
  12. Ropa, J., Cooper, S., Capitano, M. L., Van’t Hof, W., & Broxmeyer, H. E. (2021) Human Hematopoietic Stem, Progenitor, and Immune Cells Respond Ex Vivo to SARS-CoV-2 Spike Protein. Stem Cell Reviews and Reports. 17(1): 253-265. PMID: 33089452
  13. Broxmeyer, H. E.*, Capitano, M. L.*, Cooper, S., Potchanant, E. S., & Clapp, D. W. (2021) Numbers of long-term hematopoietic stem cells from bone marrow of fanca and fancc knockout mice can be greatly enhanced by their collection and processing in physioxia conditions. Blood Cells, Molecules, and Diseases. 86: 102492. PMID: 32896825 *, Co-First and Corresponding Authors
  14. Xu, D., Yang, M., Capitano, M., Guo, B., Liu, S., Wan, J., Broxmeyer, H. E., & Huang, X. (2021) Pharmacological activation of nitric oxide signaling promotes human hematopoietic stem cell homing and engraftment. Leukemia. 35(1): 229-234. PMID: 32127640
  15. Jin, Y., Huang, J., Wang, Q., He, J., Teng, Y., Jiang, R., Broxmeyer, H. E., & Guo, B. (2021). RXR Negatively Regulates Ex Vivo Expansion of Human Cord Blood Hematopoietic Stem and Progenitor Cells. Stem cell reviews and reports. 17:1456–1464. PMCID: PMC8324505
  16. Noonan, M.L., Ni, P., Agoro, R., Spencer, S.A., Sacks, S.A., Swallow, E.A., Clinkenbeard, E.L., Capitano, M.L., Thompson, W.R., Allen, M.K., Broxmeyer, H.E., and White, K.E. 2021. HIF-PHI BAY85-3934 (Molidstat) improves anemia and is associated with reduced levels of circulating FGF23 in a CKD mouse model. J. Bone and Mineral Research. 36(6):1117-1130. PMCID: PMC8255270
  17. Broxmeyer, H.E., Cooper, S., and Blum, J.S. 2021. Expression of gilt as a positive regulator of mouse hematopoietic progenitor cells. Blood Cells Molecules and Diseases. 90,102574. PMCID: PMC8338767 (available on 2022-09-01)
  18. Broxmeyer, H.E., Cooper, S.H., and Ropa, J. 2021. CXCL15/Lungkine has suppressive activity on proliferation and expansion of multi-potential, erythroid, granulocyte and macrophage progenitors in S-phase specific manner. Blood Cells Mol Dis. 91:102594. PMID: 34520986
  19. Naidu, S.R., Capitano, M., Ropa, J., Cooper, S., Huang, X., and Broxmeyer, H.E. 2021. Naidu SR, Capitano M, Ropa J, Cooper S, Huang X, Broxmeyer HE. Chromatin remodeling subunit BRM and valine regulate hematopoietic stem/progenitor cell function and self-renewal via intrinsic and extrinsic effects. Leukemia. 2021 Oct 1. doi: 10.1038/s41375-021-01426-8. Epub ahead of print. PMID: 34599272.
  20. Chen, Y., Fang. S., Ding, Q., Jiang, R., He, J., Wang, Q., Jin, Y., Huang, X., Liu, S., Capitano, M.L., Trinh, T., Teng, Y., Meng, Q., Wan, J., Broxmeyer, H.E., and Guo, B. 2021. ADGRG1 enriches for functional human hematopoietic stem cells following ex vivo expansion-induced mitochondrial oxidative stress. J Clin Invest. 131(20):e148329. PMCID: PMC8516455.
  21. Yu, H., Gao, R., Chen, S., Liu, X., Wang, Q., Cai, W., Vemula, S., Fahey, A.C., Henley, D., Kobayashi, M., Liu, S.Z., Qian, Z., Kapur, R., Broxmeyer, H.E., Gao, Z., Xi, R., and Liu, Y. 2021. Bmi1 Regulates Wnt Signaling in Hematopoietic Stem and Progenitor Cells. Stem Cell Rev Rep. 17(6):2304-2313. PMID: 34561772.
  22. Trinh, T. and Broxmeyer, H.E. 2021. Role for Leptin and Leptin Receptors in Stem Cells During Health and Disease. Stem Cell Reviews and Reports. Stem Cell Reviews and Reports. 17:511-522. PMCID: PMC7889057
  23. Ropa, J, Trinh, T., Aljoufi, A., and Broxmeyer, H.E. 2021. Consequences of coronavirus infections for primitive and mature hematopoietic cells: new insights and why it matters. Current Opinions in Hematopoiesis. 28:231-242.  PMCID: PMC8269959 (available on 2022-07-01)
  24. Broxmeyer, H.E. 2021. All in for nuclear PFKP-induced CXCR4 metastasis: a T cell acute lymphoblastic leukemia prognostic marker. (Commentary). J Clin Invest. 131(16):e151295. PMCID: PMC8363282 (available on 2022-08-16)
  25. Broxmeyer, H.E., Cooper, S.H., Yoder, K.K., Wu, Y-C, Hutchins, G.D., and Farag, S.S. 2021. The Brain: Is it a Next Frontier to Better Understand the Regulation and Control of Hematopoiesis for Future Modulation and Treatment? Stem Cell Reports and Reviews. Solicited Spotlight Commentary. 17:1083-1090.
  26. Bhatti FUR, Dadwal UC, Valuch CR, Tewari NP, Awosanya OD, de Andrade Staut C, Sun S, Mendenhall SK, Perugini AJ 3rd, Nagaraj RU, Battina HL, Nazzal MK, Blosser RJ, Maupin KA, Childress PJ, Li J, Kacena MA. The effects of high fat diet, bone healing, and BMP-2 treatment on endothelial cell growth and function. Bone. 2021 May;146:115883. PMCID: PMC8009863.
  27. Dadwal UC, Bhatti FUR, Awosanya OD, Nagaraj RU, Perugini AJ 3rd, Sun S, Valuch CR, de Andrade Staut C, Mendenhall SK, Tewari NP, Mostardo SL, Nazzal MK, Battina HL, Zhou D, Kanagasabapathy D, Blosser RJ, Mulcrone PL, Li J, Kacena MA. The effects of bone morphogenetic protein 2 and thrombopoietin treatment on angiogenic properties of endothelial cells derived from the lung and bone marrow of young and aged, male and female mice. FASEB J. 2021 Sep;35(9):e21840. PMCID: PMC8386046.
  28.  Liu L, Li H, Patterson AM, Plett PA, Sampson CH, Mohammad KS, Capitano ML, Singh P, Yao C, Orschell CM, Pelus LM. Upregulation of SIRT1 Contributes to dmPGE2-dependent Radioprotection of Hematopoietic Stem Cells. Stem Cell Rev Rep. 2022 Mar 23. doi: 10.1007/s12015-022-10368-2. Epub ahead of print. PMID: 35318613.
  29. Broxmeyer HE*, Ropa J*, Capitano ML*, Cooper S, Racioppi L, Sankar U. CaMKK2 Knockout Bone Marrow Cells Collected/Processed in Low Oxygen (Physioxia) Suggests CaMKK2 as a Hematopoietic Stem to Progenitor Differentiation Fate Determinant. Stem Cell Rev Rep. 2022 Mar 9. doi: 10.1007/s12015-021-10306-8. Epub ahead of print. PMID: 35262902. *, Co-first authors.
  30. Capitano ML*, Sammour Y, Ropa J, Legendre M, Mor-Vaknin N, Markovitz DM. DEK, a nuclear protein, is chemotactic for hematopoietic stem/progenitor cells acting through CXCR2 and Gαi signaling. J Leukoc Biol. 2022 Feb 8. doi: 10.1002/JLB.3AB1120-740R. Epub ahead of print. PMID: 35137444.
  31. Ulrich BJ, Kharwadkar R, Chu M, Pajulas, A, Muralidharan C, Koh B, Fu Y, Gao H, Hayes TA, Zhou HM, Goplen NP, Nelson AS, Liu Y, Linneman AK, Turner MJ, Licona-Limón P, Flavell RA, Sun J, Kaplan MH. (2022) Allergic airway recall responses require IL-9 from resident memory CD4+ T cells. Science Immunol. 7(69):eabg9296.
  32. Fu Y, Wang J, Zhou B, Pajulas A, Gao H, Ramdas B, Koh B, Ulrich BJ, Yang S, Kapur R, Renauld J-C, Paczesny S, Liu Y, Tighe RM, Licona-Limon P, Flavell RA, Takatsuka S, Kitamura D, Tepper RS, Sun J, Kaplan MH. (2022) An IL-9-pulmonary macrophage axis defines the allergic lung inflammatory environment. Science Immunol. 7(68):eabi9768.