Publications

Selected CCEH Member Publications (from February 2023 through October 2024). Names of CCEH members are in bold. 

  1. Wang X, Cooper S, Broxmeyer HE, Kapur R. Transient regulation of RNA methylation in human hematopoietic stem cells promotes their homing and engraftment. Leukemia. 2023 Feb;37(2):453-464. doi: 10.1038/s41375-022-01761-4. Epub 2022 Dec 2. PMID: 36460765; PMCID: PMC9898034.

  2. Pasupuleti SK, Chao K, Ramdas B, Kanumuri R, Palam LR, Liu S, Wan J, Annesley C, Loh ML, Stieglitz E, Burke MJ, Kapur R. Potential clinical use of azacitidine and MEK inhibitor combination therapy in PTPN11-mutated juvenile myelomonocytic leukemia. Mol Ther. 2023 Apr 5;31(4):986-1001. doi: 10.1016/j.ymthe.2023.01.030. Epub 2023 Feb 3. PMID: 36739480; PMCID: PMC10124140.

  3. Jiang J, Srivastava S, Liu S, Seim G, Claude R, Zhong M, Cao S, Davé U, Kapur R, Mosley AL, Zhang C, Wan J, Fan J, Zhang J. Asparagine starvation suppresses histone demethylation through iron depletion. iScience. 2023 Mar 16;26(4):106425. doi: 10.1016/j.isci.2023.106425. PMID: 37034982; PMCID: PMC10074807.

  4. Wu T, Orschell CM. The delayed effects of acute radiation exposure (DEARE): characteristics, mechanisms, animal models, and promising medical countermeasures. Int J Radiat Biol. 2023;99(7):1066-1079. doi: 10.1080/09553002.2023.2187479. Epub 2023 Mar 16. PMID: 36862990; PMCID: PMC10330482.

  5. Wu T, Pelus LM, Plett PA, Sampson CH, Chua HL, Fisher A, Feng H, Liu L, Li H, Ortiz M, Chittajallu S, Luo Q, Bhatwadekar AD, Meyer TB, Zhang X, Zhou D, Fischer KD, McKinzie DL, Miller SJ, Orschell CM. Further Characterization of Multi-Organ DEARE and Protection by 16,16 Dimethyl Prostaglandin E2 in a Mouse Model of the Hematopoietic Acute Radiation Syndrome. Radiat Res. 2023 May 1;199(5):468-489. doi: 10.1667/RADE-22-00208.1. PMID: 37014943; PMCID: PMC10278147.

  6. Schorr C, Krishnan MS, Capitano M. Deficits in our understanding of natural killer cell development in mouse and human. Curr Opin Hematol. 2023 Jul 1;30(4):106-116. doi: 10.1097/MOH.0000000000000765. Epub 2023 Apr 18. PMID: 37074304; PMCID: PMC10239331.

  7. Palam LR, Ramdas B, Pickerell K, Pasupuleti SK, Kanumuri R, Cesarano A, Szymanski M, Selman B, Dave UP, Sandusky G, Perna F, Paczesny S, Kapur R. Loss of Dnmt3a impairs hematopoietic homeostasis and myeloid cell skewing via the PI3Kinase pathway. JCI Insight. 2023 May 8;8(9):e163864. doi: 10.1172/jci.insight.163864. PMID: 36976647; PMCID: PMC10243813.

  8. Pajulas A, Fu Y, Cheung CCL, Chu M, Cannon A, Alakhras N, Zhang J, Ulrich BJ, Nelson AS, Zhou B, Kaplan MH. Interleukin-9 promotes mast cell progenitor proliferation and CCR2-dependent mast cell migration in allergic airway inflammation. Mucosal Immunol. 2023 Aug;16(4):432-445. doi: 10.1016/j.mucimm.2023.05.002. Epub 2023 May 11. PMID: 37172907; PMCID: PMC10482122.

  9. Karnik SJ, Nazzal MK, Kacena MA, Bruzzaniti A. Megakaryocyte Secreted Factors Regulate Bone Marrow Niche Cells During Skeletal Homeostasis, Aging, and Disease. Calcif Tissue Int. 2023 Jul;113(1):83-95. doi: 10.1007/s00223-023-01095-y. Epub 2023 May 27. PMID: 37243755; PMCID: PMC11179715.

  10. Mesfin FM, Manohar K, Shelley WC, Brokaw JP, Liu J, Ma M, Markel TA. Stem cells as a therapeutic avenue for active and long-term complications of Necrotizing Enterocolitis. Semin Pediatr Surg. 2023 Jun;32(3):151311. doi: 10.1016/j.sempedsurg.2023.151311. Epub 2023 Jun 1. PMID: 37276782; PMCID: PMC10330659.

  11. Pasupuleti SK, Ramdas B, Burns SS, Palam LR, Kanumuri R, Kumar R, Pandhiri TR, Dave UP, Yellapu NK, Zhou X, Zhang C, Sandusky GE, Yu Z, Honigberg MC, Bick AG, Griffin GK, Niroula A, Ebert BL, Paczesny S, Natarajan P, Kapur R. Obesity-induced inflammation exacerbates clonal hematopoiesis. J Clin Invest. 2023 Jun 1;133(11):e163968. doi: 10.1172/JCI163968. PMID: 37071471; PMCID: PMC10231999.

  12. Kaczmarek R, Piñeros AR, Patterson PE, Bertolini TB, Perrin GQ, Sherman A, Born J, Arisa S, Arvin MC, Kamocka MM, Martinez MM, Dunn KW, Quinn SM, Morris JJ, Wilhelm AR, Kaisho T, Munoz-Melero M, Biswas M, Kaplan MH, Linnemann AK, George LA, Camire RM, Herzog RW. Factor VIII trafficking to CD4+ T cells shapes its immunogenicity and requires several types of antigen-presenting cells. Blood. 2023 Jul 20;142(3):290-305. doi: 10.1182/blood.2022018937. PMID: 37192286; PMCID: PMC10375270.

  13. Biswas M, So K, Bertolini TB, Krishnan P, Rana J, Muñoz-Melero M, Syed F, Kumar SRP, Gao H, Xuei X, Terhorst C, Daniell H, Cao S, Herzog RW. Distinct functions and transcriptional signatures in orally induced regulatory T cell populations. Front Immunol. 2023 Oct 26;14:1278184. doi: 10.3389/fimmu.2023.1278184. PMID: 37954612; PMCID: PMC10637621.

  14. Broxmeyer HE, Luchsinger LL, Weinberg RS, Jimenez A, Frenet EM, Van't Hof W, Capitano ML, Hillyer CD, Kaplan MH, Cooper S, Ropa J. Insights into highly engraftable hematopoietic cells from 27-year cryopreserved umbilical cord blood. Cell Rep Med. 2023 Nov 21;4(11):101259. doi: 10.1016/j.xcrm.2023.101259. Epub 2023 Oct 31. PMID: 37913777; PMCID: PMC10694620.

  15. Niese ML, Glosson-Byers N, Serezani APM, Alakhras NS, Kaplan MH. STAT3 Signaling Heterogeneity Underlies Cytokine-Expressing Fate in Th17 Cultures. Immunohorizons. 2023 Nov 1;7(11):747-754. doi: 10.4049/immunohorizons.2300072. PMID: 37938185; PMCID: PMC10695415.

  16. Patterson AM, Orschell CM, Pelus LM. Hematopoietic Stem Cell Identification Postirradiation. Methods Mol Biol. 2023;2567:127-140. doi: 10.1007/978-1-0716-2679-5_9. PMID: 36255699; PMCID: PMC11190781.

  17. Plett PA, Pelus LM, Orschell CM. Establishing a Murine Model of the Hematopoietic Acute Radiation Syndrome. Methods Mol Biol. 2023;2567:251-262. doi: 10.1007/978-1-0716-2679-5_16. PMID: 36255706; PMCID: PMC11192174.

  18. Sherman A, Bertolini TB, Arisa S, Herzog RW, Kaczmarek R. Factor IX administration in the skin primes inhibitor formation and sensitizes hemophilia B mice to systemic factor IX administration. Res Pract Thromb Haemost. 2023 Nov 4;7(8):102248. doi: 10.1016/j.rpth.2023.102248. PMID: 38193070; PMCID: PMC10772885.

  19. Kumar SRP, Biswas M, Cao D, Arisa S, Muñoz-Melero M, Lam AK, Piñeros AR, Kapur R, Kaisho T, Kaufman RJ, Xiao W, Shayakhmetov DM, Terhorst C, de Jong YP, Herzog RW. TLR9-independent CD8+ T cell responses in hepatic AAV gene transfer through IL-1R1-MyD88 signaling. Mol Ther. 2024 Feb 7;32(2):325-339. doi: 10.1016/j.ymthe.2023.11.029. Epub 2023 Dec 5. PMID: 38053332; PMCID: PMC10861967.

  20. Langevin B, Singh P, Plett PA, Sampson CH, Masters A, Gibbs A, Faria E, Triesler S, Zodda A, Jackson IL, Orschell CM, Gopalakrishnan M, Pelus LM. Pharmacokinetics and Biodistribution of 16,16 dimethyl Prostaglandin E2 in Non-Irradiated and Irradiated Mice and Non-Irradiated Non-Human Primates. Radiat Res. 2024 Jan 1;201(1):7-18. doi: 10.1667/RADE-23-00040.1. PMID: 38019093; PMCID: PMC11163368.

  21. Jiang W, Maldeney AR, Yuan X, Richer MJ, Renshaw SE, Luo W. Ipsilateral immunization after a prior SARS-CoV-2 mRNA vaccination elicits superior B cell responses compared to contralateral immunization. Cell Rep. 2024 Jan 23;43(1):113665. doi: 10.1016/j.celrep.2023.113665. Epub 2024 Jan 8. PMID: 38194344; PMCID: PMC10851277.

  22. Pattnaik A, Dhalech AH, Condotta SA, Corn C, Richer MJ, Snell LM, Robinson CM. A viral-specific CD4+ T cell response protects female mice from Coxsackievirus B3 infection. Front Immunol. 2024 Jan 11;14:1327384. doi: 10.3389/fimmu.2023.1327384. PMID: 38274806; PMCID: PMC10808549.

  23. Liu J, Joseph S, Manohar K, Lee J, Brokaw JP, Shelley WC, Markel TA. Role of innate T cells in necrotizing enterocolitis. Front Immunol. 2024 Feb 8;15:1357483. doi: 10.3389/fimmu.2024.1357483. PMID: 38390341; PMCID: PMC10881895.

  24. Rana J, Herzog RW, Muñoz-Melero M, Yamada K, Kumar SRP, Lam AK, Markusic DM, Duan D, Terhorst C, Byrne BJ, Corti M, Biswas M. B cell focused transient immune suppression protocol for efficient AAV readministration to the liver. Mol Ther Methods Clin Dev. 2024 Feb 20;32(1):101216. doi: 10.1016/j.omtm.2024.101216. PMID: 38440160; PMCID: PMC10911854.

  25. Mohamad SF, El Koussa R, Ghosh J, Blosser R, Gunawan A, Layer J, Zhang C, Karnik S, Davé U, Kacena MA, Srour EF. Osteomacs promote maintenance of murine hematopoiesis through megakaryocyte-induced upregulation of Embigin and CD166. Stem Cell Reports. 2024 Apr 9;19(4):486-500. doi: 10.1016/j.stemcr.2024.02.004. Epub 2024 Mar 7. PMID: 38458190; PMCID: PMC11096441.

  26. Mohamad SF, Kacena MA. Isolation of Murine Neonatal and Adult Osteomacs to Examine Their Role in the Hematopoietic Niche. Methods Mol Biol. 2024 Mar 21. doi: 10.1007/7651_2024_535. Epub ahead of print. PMID: 38507212.

  27. Pasupuleti SK, Kapur R. The impact of obesity-induced inflammation on clonal hematopoiesis. Curr Opin Hematol. 2024 Jul 1;31(4):193-198. doi: 10.1097/MOH.0000000000000819. Epub 2024 Apr 19. PMID: 38640133; PMCID: PMC11197996.

  28. Gutch S, Beasley L, Cooper S, Kaplan MH, Capitano ML, Ropa J. Protocol for enrichment and functional analysis of human hematopoietic cells from umbilical cord blood. STAR Protoc. 2024 Jun 21;5(2):103024. doi: 10.1016/j.xpro.2024.103024. Epub 2024 Apr 23. PMID: 38662544; PMCID: PMC11061328.

  29. Nichols C, Do-Thi VA, Peltier DC. Noncanonical microprotein regulation of immunity. Mol Ther. 2024 Sep 4;32(9):2905-2929. doi: 10.1016/j.ymthe.2024.05.021. Epub 2024 May 11. PMID: 38734902; PMCID: PMC11403233.

  30. Cao D, Byrne BJ, de Jong YP, Terhorst C, Duan D, Herzog RW, Kumar SRP. Innate Immune Sensing of Adeno-Associated Virus Vectors. Hum Gene Ther. 2024 Jul;35(13-14):451-463. doi: 10.1089/hum.2024.040. Epub 2024 Jul 5. PMID: 38887999; PMCID: PMC11310564.

  31. Denizli M, Ropa J, Beasley L, Ghosh J, DeVanna K, Spice T, Haneline LS, Capitano M, Kua KL. Glucose intolerance as a consequence of hematopoietic stem cell dysfunction in offspring of obese mice. Mol Metab. 2024 Oct;88:102008. doi: 10.1016/j.molmet.2024.102008. Epub 2024 Aug 12. PMID: 39142562; PMCID: PMC11395717

  32. Plett PA, Chua HL, Wu T, Sampson CH, Guise TA, Wright L, Pagnotti GM, Feng H, Chin-Sinex H, Pike F, Cox GN, MacVittie TJ, Sandusky G, Orschell CM. Effect of Age at Time of Irradiation, Sex, Genetic Diversity, and Granulopoietic Cytokine Radiomitigation on Lifespan and Lymphoma Development in Murine H-ARS Survivors. Radiat Res. 2024 Sep 1;202(3):580-598. doi: 10.1667/RADE-24-00065.1. PMID: 39099001.

  33. Hurwitz SN, Kobulsky DR, Jung SK, Chia JJ, Butler JM, Kurre P. CCR2 cooperativity promotes hematopoietic stem cell homing to the bone marrow. Sci Adv. 2024 Sep 20;10(38):eadq1476. doi: 10.1126/sciadv.adq1476. Epub 2024 Sep 18. PMID: 39292787; PMCID: PMC11409967.

  34. Chen Q, Abdi AM, Luo W, Yuan X, Dent AL. T follicular regulatory cells in food allergy promote IgE via IL-4. JCI Insight. 2024 Oct 8;9(19):e171241. doi: 10.1172/jci.insight.171241. PMID: 39377224; PMCID: PMC11466180.