Faculty

Christie M. Orschell, PhD

Robert Wallace Miller Professor of Oncology

Phone (317) 278-2834

Address

Joseph E. Walther Hall, Room C341
980 W. Walnut St.

Indianapolis , IN 46202

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Titles & Appointments

Robert Wallace Miller Professor of Oncology
Professor of Medicine
Adjunct Professor of Anatomy, Cell Biology & Physiology

Education

1994 FEL Postdoctoral Fellowship, Indiana University, Indianapolis, IN

1992 PhD Indiana University

1986 BS Indiana University
Research

Acute and delayed effects of radiation exposure on the hematopoietic system and hematopoietic stem cell biology
Publications

Further Characterization of the Mitigation of Radiation Lethality by Protective Wounding.
Dynlacht JR; Garrett J; Joel R; Lane K; Mendonca MS; Orschell CM; Radiation research 2017 Apr 24

An oral Hemokine<sup>TM</sup>, a-methylhydrocinnamate, enhances myeloid and neutrophil recovery following irradiation in vivo.
Faller DV; Castaneda SA; Zhou D; Vedamony M; Newburger PE; White GL; Kosanke S; Plett PA; Orschell CM; Boosalis MS; Perrine SP; Blood cells, molecules & diseases 2016 Oct 31

Combined Hydration and Antibiotics with Lisinopril to Mitigate Acute and Delayed High-dose Radiation Injuries to Multiple Organs.
Fish BL; Gao F; Narayanan J; Bergom C; Jacobs ER; Cohen EP; Moulder JE; Orschell CM; Medhora M; Health physics 2016 Nov

Delayed Effects of Acute Radiation Exposure in a Murine Model of the H-ARS: Multiple-Organ Injury Consequent to <10 Gy Total Body Irradiation.
Unthank JL; Miller SJ; Quickery AK; Ferguson EL; Wang M; Sampson CH; Chua HL; DiStasi MR; Feng H; Fisher A; Katz BP; Plett PA; Sandusky GE; Sellamuthu R; Vemula S; Cohen EP; MacVittie TJ; Orschell CM; Health physics 2015 Nov

The H-ARS Dose Response Relationship (DRR): Validation and Variables.
Plett PA; Sampson CH; Chua HL; Jackson W; Vemula S; Sellamuthu R; Fisher A; Feng H; Wu T; MacVittie TJ; Orschell CM; Health physics 2015 Nov

Relationships Between Renal Parameters and Serum and Urine Markers of Inflammation in Those With and Without HIV Infection.
Shinha T; Mi D; Liu Z; Orschell CM; Lederman MM; Gupta SK; AIDS research and human retroviruses 2015 Feb 26

Subcutaneous wounding postirradiation reduces radiation lethality in mice.
Garrett J; Orschell CM; Mendonca MS; Bigsby RM; Dynlacht JR; Radiation research 2014 May 8

Prognostic biomarkers for acute graft-versus-host disease risk after cyclophosphamide-fludarabine nonmyeloablative allotransplantation.
Nelson RP Jr; Khawaja MR; Perkins SM; Elmore L; Mumaw CL; Orschell C; Paczesny S; Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation 2014 Jul 10

Survival efficacy of the PEGylated G-CSFs Maxy-G34 and neulasta in a mouse model of lethal H-ARS, and residual bone marrow damage in treated survivors.
Chua HL; Plett PA; Sampson CH; Katz BP; Carnathan GW; MacVittie TJ; Lenden K; Orschell CM; Health physics 2014 Jan

PEGylated G-CSF (BBT-015), GM-CSF (BBT-007), and IL-11 (BBT-059) analogs enhance survival and hematopoietic cell recovery in a mouse model of the hematopoietic syndrome of the acute radiation syndrome.
Plett PA; Chua HL; Sampson CH; Katz BP; Fam CM; Anderson LJ; Cox GN; Orschell CM; Health physics 2014 Jan

Pyk2 regulates megakaryocyte-induced increases in osteoblast number and bone formation.
Cheng YH; Hooker RA; Nguyen K; Gerard-O'Riley R; Waning DL; Chitteti BR; Meijome TE; Chua HL; Plett AP; Orschell CM; Srour EF; Mayo LD; Pavalko FM; Bruzzaniti A; Kacena MA; Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2013 Jun

Long-term hematopoietic stem cell damage in a murine model of the hematopoietic syndrome of the acute radiation syndrome.
Chua HL; Plett PA; Sampson CH; Joshi M; Tabbey R; Katz BP; MacVittie TJ; Orschell CM; Health physics 2012 Oct

Establishing a murine model of the hematopoietic syndrome of the acute radiation syndrome.
Plett PA; Sampson CH; Chua HL; Joshi M; Booth C; Gough A; Johnson CS; Katz BP; Farese AM; Parker J; MacVittie TJ; Orschell CM; Health physics 2012 Oct

Recovery from hematopoietic injury by modulating prostaglandin E(2) signaling post-irradiation.
Hoggatt J; Singh P; Stilger KN; Plett PA; Sampson CH; Chua HL; Orschell CM; Pelus LM; Blood cells, molecules & diseases 2012 Nov 30

Thrice weekly azacitidine does not improve hematological responses in lower-risk myelodysplastic syndromes: a study of the Hoosier Oncology Group.
Sayar H; Chan RJ; Orschell CM; Chan EM; Yu Z; Hood D; Plett A; Yang Z; Hui CL; Nabinger SC; Kohlbacher KJ; West ES; Walter A; Sampson C; Wu J; Cripe LD; Leukemia research 2011 Mar 21

Deficiency of Src family kinases compromises the repopulating ability of hematopoietic stem cells.
Orschell CM; Borneo J; Munugalavadla V; Ma P; Sims E; Ramdas B; Yoder MC; Kapur R; Experimental hematology 2008 Mar 17

Src family kinase-mediated negative regulation of hematopoietic stem cell mobilization involves both intrinsic and microenvironmental factors.
Borneo J; Munugalavadla V; Sims EC; Vemula S; Orschell CM; Yoder M; Kapur R; Experimental hematology 2007 Jul

Shp-2 heterozygous hematopoietic stem cells have deficient repopulating ability due to diminished self-renewal.
Chan RJ; Li Y; Hass MN; Walter A; Voorhorst CS; Shelley WC; Yang Z; Orschell CM; Yoder MC; Experimental hematology 2006 Sep

Effects of HIV protease inhibitor ritonavir on Akt-regulated cell proliferation in breast cancer.
Srirangam A; Mitra R; Wang M; Gorski JC; Badve S; Baldridge L; Hamilton J; Kishimoto H; Hawes J; Li L; Orschell CM; Srour EF; Blum JS; Donner D; Sledge GW; Nakshatri H; Potter DA; Clinical cancer research : an official journal of the American Association for Cancer Research 2006 Mar 15

Endothelial-monocyte-activating polypeptide II induces migration of endothelial progenitor cells via the chemokine receptor CXCR3.
Hou Y; Plett PA; Ingram DA; Rajashekhar G; Orschell CM; Yoder MC; March KL; Clauss M; Experimental hematology 2006 Aug

Rapid mobilization of murine and human hematopoietic stem and progenitor cells with AMD3100, a CXCR4 antagonist.
Broxmeyer HE; Orschell CM; Clapp DW; Hangoc G; Cooper S; Plett PA; Liles WC; Li X; Graham-Evans B; Campbell TB; Calandra G; Bridger G; Dale DC; Srour EF; The Journal of experimental medicine 2005 Apr 18

A role for the Fanconi anemia C protein in maintaining the DNA damage-induced G2 checkpoint.
Freie BW; Ciccone SL; Li X; Plett PA; Orschell CM; Srour EF; Hanenberg H; Schindler D; Lee SH; Clapp DW; The Journal of biological chemistry 2004 Sep 17

Modulation of in vitro proliferation kinetics and primitive hematopoietic potential of individual human CD34+CD38-/lo cells in G0.
Srour EF; Tong X; Sung KW; Plett PA; Rice S; Daggy J; Yiannoutsos CT; Abonour R; Orschell CM; Blood 2004 Dec 21

Impact of modeled microgravity on migration, differentiation, and cell cycle control of primitive human hematopoietic progenitor cells.
Plett PA; Abonour R; Frankovitz SM; Orschell CM; Experimental hematology 2004 Aug

Distribution of marrow repopulating cells between bone marrow and spleen early after transplantation.
Plett PA; Frankovitz SM; Orschell CM; Blood 2003 May 29

Fanconi anemia type C-deficient hematopoietic stem/progenitor cells exhibit aberrant cell cycle control.
Li X; Plett PA; Yang Y; Hong P; Freie B; Srour EF; Orschell CM; Clapp DW; Haneline LS; Blood 2003 May 22

Peripheral blood "endothelial progenitor cells" are derived from monocyte/macrophages and secrete angiogenic growth factors.
Rehman J; Li J; Orschell CM; March KL; Circulation 2003 Mar 4

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