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The full list of publications for the IU School of Medicine 3D Stem Cell Biology Research Group is available on PubMed.


The histone demethylase LSD1 regulates inner ear progenitor differentiation through direct interactions with Pax2 and the NuRD complex
Patel D, Shimomura A, Holley MC, Hashino E.
PLoS One. 2018 Jan 25;13(1):e0191689.

Hair follicle development in mouse pluripotent stem cell-derived skin organoids
Lee J, Boescke R, Tang PC, Hartman BH, Heller S, Koehler KR.
Cell Reports. 2018 January 2;22(1):242-254


Generation of inner ear organoids containing functional hair cells from human pluripotent stem cells
Koehler KR, Nie J, Longworth-Mills E, Liu XP, Lee J, Holt JR, Hashino E.
Nature Biotechnology. 2017 June;35(6):583-589.

Organoid technologies meet genome engineering
Nie J, Hashino E.
EMBO Reports. 2017 March;18(3):367-376.

Directed differentiation of mouse embryonic stem cells into inner ear sensory epithelia in 3D culture
Nie J, Koehler KR, Hashino E.
Methods In Molecular Biology. 2017;1597:67-83.

Inner ear organoids: Recapitulating inner ear development in 3D culture
Elghouche AN, Nelson RF, Hashino E. (2017)
In: T. Tsuji (Eds.) Organ Regeneration Based on Developmental Biology. Springer Nature, Singapore.


Modulation of Wnt signaling enhances inner ear organoid development in 3D culture
DeJonge RE, Liu XP, Deig CR, Heller S, Koehler KR, Hashino E.
PloS One. 2016 September 8;11(9):e0162508.

Functional development of mechanosensitive hair cells in stem cell-derived organoids parallels native vestibular hair cells
Liu XP, Koehler KR, Mikosz AM, Hashino E, Holt JR.
Nature Communications. 2016 May 24;7:11508.

Generating inner ear organoids from mouse embryonic stem cells
Longworth-Mills E, Koehler KR, Hashino E.
Methods in Molecular Biology. 2016;1341: 391-406.


Tlx3 promotes glutamatergic neuronal subtype specification through direct interactions with the chromatin modifier CBP
Shimomura A, Patel D, Wilson SM, Koehler KR, Khanna R, Hashino E.
PloS One. 2015 August 10;10(8):e0135060.


Recapitulating inner ear development with pluripotent stem cells: biology and translation
Koehler KR, Malone AK, Hashino E. (2014)
In: R. Romand and I. Varela-Nieto (Eds.) Development of the Auditory and Vestibular Systems 4th edition. Elsevier, San Diego.

3D mouse embryonic stem cell culture for generating inner ear organoids
Koehler KR, Hashino E.
Nature Protocols. 2014;9(6):1229–1244


Generation of inner ear sensory epithelia in a defined 3D culture
Koehler KR, Mikosz AM, Molosh AI, Patel D, Hashino E.
Nature. 2013 August 8;500(7461):217-221

Retinoic acid deficiency impairs the vestibular function
Romand R, Krezel W, Fraulob V, Messaddeq N, Kessler P, Bianchetti L, Cammas L, Hashino E, Dolle P.
Journal of Neuroscience. 2013 March 27;33(13):5856-66.

Epigenetic regulation of neuronal differentiation from embryonic stem cells
Shimomura A, Hashino E. (2013)
In: S. Wislet-Gendebien (Ed.) Trends in Cell Signaling Pathways in Neuronal Fate Decision. INTECH, Rijeka, Croatia.


Extended passaging increases the efficiency of neural differentiation of induced pluripotent stem cells
Koehler KR, Tropel P, Theile JW, Kondo T, Cummins TR, Viville S, Hashino E.
BMC Neuroscience. 2011 August 10;12(1):82