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Indiana Center for Regenerative Medicine and Engineering

Indiana Center for Regenerative Medicine and Engineering

The Indiana Center for Regenerative Medicine and Engineering is a multidisciplinary research center focused on the development of novel technologies that regenerate cells and tissues affected by age, disease, damage or congenital effects, ultimately leading to wound care and healing for patients in Indiana and beyond. Located on the Indiana University School of Medicine–Indianapolis campus, the center is comprised of more than 30 scientists and staff working to reduce the number of amputations in the state of Indiana and deliver critically acclaimed science.

Research Updates

To stay current on the medical research work at IU School of Medicine’s statewide campuses, follow the IU School of Medicine research blog, where investigators throughout the school’s academic departments post updates about their work.


Tissue Nanotransfection

Investigators at the Center have developed a non-invasive, nanochip device that uses tissue nanotransfection technology to reprogram one type of tissue into another with a simple touch and electric spark that is harmless to the body.

Learn More

Diabetic Foot Consortium

Indiana University School of Medicine is leading the first study of the national Diabetic Foot Consortium sponsored by the National Institutes of Health (NIH) National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK). The goal of the study is to prevent reopening of closed wounds by identifying a biomarker that would predict such recurrence during the process of standard wound care. Such an advanced approach to managing diabetic foot ulcers is likely to decrease amputation rates across the country.
Read the IU School of Medicine press release

Interdisciplinary Collaboration

Regenerative medicine solutions require expertise across disciplines in medicine and engineering to develop transformative solutions in science and health care. With support from the state of Indiana, philanthropic donors, foundations and the federal government, the center partners with private industry to develop new treatments for disease.

The center’s team of investigators are located throughout the state of Indiana, converging toward excellence in regenerative medicine and engineering, in partnership with industry and government agencies. Together, this team is working to address four core pillars: Cell-Based Therapies; Tissue Engineering; Wound, Burn, and Inflammation; and Military Health.


The power of healing through innovative technology

Indiana Center for Regenerative Medicine and Engineering


Emerging Training Programs

The Indiana Center for Regenerative Medicine and Engineering is proud to introduce a new Regenerative Medicine and Technologies Graduate Program here at Indiana University School of Medicine. The program will primarily focus on developing a skilled workforce to shape the future of regenerative medicine. This program emphasizes training scholars in regenerative medicine-based innovations, regulatory science, and supply chain management. Soon the ICRME will also offer a Master’s program In regenerative medicine.

Learn More

Center Leadership

Chandan Sen, PhD

Director, Center for Regenerative Medicine and Engineering

Chandan Sen, PhD, serves as the Associate Vice President of Research at Indiana University, and as Vice Chair of Research at IU School of Medicine Department of Surgery. He also serves as the Director of the Indiana Center for Regenerative Medicine and Engineering. Dr. Sen’s team is made up of more than 30 scientists and staff who study how to tap into the power of regenerative medicine and engineering to heal burns, develop new therapies for diabetic complications, treat injured soldiers, and even regrow damaged and diseased tissue.

Watch Monthly Directors Video

Mervin C. Yoder, MA, MD

Director Emeritus, Indiana Center for Regenerative Medicine and Engineering

Mervin C. Yoder, MA, MD, became an Assistant Professor of Pediatrics at the Indiana University School of Medicine in 1985. He was awarded tenure in 1991, and promoted to Professor of Pediatrics and of Biochemistry and Molecular Biology in 2000. In 2004, Dr. Yoder was named the Richard and Pauline Klingler Professor of Pediatrics. In March 2008, he was promoted to Director of the Herman B. Wells Center for Pediatric Research and Associate Chair for Basic Research in the Department of Pediatrics. In 2011 he was chosen to serve as Assistant Dean for Entrepreneurial Research for the IU School of Medicine and Associate Director for Entrepreneurship for the Indiana Clinical and Translational Sciences Institute. He was promoted to Distinguished Professor in 2013.

Watch Monthly Directors Video
Photo of Dr. Gayle Gordillo

Gayle M. Gordillo, MD

Medical Director of the Comprehensive Wound Care Center at IU Methodist Hospital

Gayle Gordillo, MD, is a plastic surgeon in Indianapolis, Indiana and is affiliated with Indiana University Health Medical Center. She has worked on multiple different projects studying mechanisms regulating angiogenesis in both wound healing and endothelial cell tumor biology. She has expertise in the design and execution of both sponsored clinical trials and investigator-initiated clinical and translational research. Additional funded projects that she has worked on are thermal burns, oxygen imaging, and nutritional interventions to treat diabetes and stroke. She received her medical degree from The Ohio State University College of Medicine and has been in practice for more than 20 years. She is one of 20 doctors at Indiana University Health Medical Center who specialize in Plastic Surgery Dr. Gordillo has co-authored many articles in well-known publications, including Antioxidants and Redox Signaling, Journal of Biological Chemistry, American Journal of Physiology-Cell Physiology and Plastic and Reconstructive Surgery.


Check out what the Indiana Center for Regenerative Medicine and Engineering is doing in the monthly director’s update.
photo of Sashwati Roy PhD

Sashwati Roy, PhD

Director of Clinical Research at Comprehensive Wound Care Center at IU Methodist Hospital

Sashwati Roy, PhD is a Professor of Surgery and Director of Clinical Research at IU Health Comprehensive Wound Center. She is an expert in inflammation and macrophage biology in chronic wounds. She did her PhD from the University of Kuopio, Finland, and post-doc from the University of California, Berkeley. Her research interests include wound inflammation, mechanisms of resolution of diabetic wound infection, tissue repair, and cellular plasticity. Her laboratory recently highlighted immune cell plasticity in wound repair. The work published in Nature Communication in March 2018.

Watch Monthly Directors Video
Photo of Brent Toto

Brent D. Toto, MHA

Brent D. Toto is the Associate Director for the Indiana Center for Regenerative Medicine and Engineering at Indiana University located on the Indianapolis campus. Mr. Toto is tasked with strategic planning and operations of the Center. He also has significant operational involvement in military and industry research partnerships within and outside the Center operations. He has extensive leadership experience in building teams and improving and expanding healthcare programs across the continuum of care and research related operations.

Mentee Research Development Program

Photo of Al Hassanein, MDDr. Al Hassanein is a Harvard and Johns Hopkins trained, board-certified plastic surgeon. He was born and raised in Illinois. and graduated college magna cum laude at the University of Illinois. He finished medical school at the University of Illinois in 2005. He completed a general surgery residency at the University of California San Diego. He trained in plastic surgery at the Harvard plastic surgery program and completed an additional specialized Reconstructive Microsurgery/Breast fellowship at Johns Hopkins in Baltimore.

Watch Mentee talk about his experience in the program

Schedule an Interview

Schedule an interview with an IU School of Medicine faculty member or request materials and resources about regenerative medicine research by contacting the IU School of Medicine media relations team.

Contact Media Relations