Clinical Research Imaging

Siemens Vision 600 (at Goodman Hall)
A research-dedicated Siemens Biograph Vision 600 PET/CT system was installed at the IU Health Neuroscience Center in June 2020.  This system is the first system worldwide to integrate a TwinBeam dual energy (TBDE) CT scanner with PET.  The PET component consists of 8 detector rings with 38 detector blocks per ring. Each detector block consists of a 4x2 arrangement of mini-blocks (5x5 array of 3.2x3.2x20 mm crystals coupled to a SiPM array (16x16 mm with 16 output channels).  The PET system has 25.6 cm axial field-of-view and a 78-cm bore. Intrinsic spatial resolution for the system is approximately 3.5 mm FWHM near the center of the field-of-view with a sensitivity of 16.4 kcps/MBq based on NEMA  NU-2 conformance standards.  Time-of-flight resolution is less than 210 ps for all detector combinations.  PET features include: dynamic listmode data acquisition capabilities; multiple filter selections and algorithms for reconstruction, including OSEM and FBP; FlowMotion technology for continuous bed motion data acquisition.   

Siemens Biograph mCT (at R2 Building)
A research-dedicated Siemens Biograph PET-CT scanner was installed in 2012 and upgraded in 2017 at the IU Health Neuroscience Center.  PET features include:  TrueV technology for extended FOV up to 78 cm; HD∙PET and ultraHD∙PET/Siemens Time of Flight  technology for 2 mm intrinsic resolution and improved sensitivity; TrueC, model-based Compton scatter correction; patented high-density 4x4x20 mm LSO detectors with decay time of 40 ns and coincidence timing of 4.5 ns; HI-REZ detectors; sinogram mode and dynamic listmode data acquisition capabilities; multiple filter selections and algorithms for reconstruction, including OSEM and FBP; and FlowMotion Techology for single continuous motion of the patient table.

Siemens Vision 600 (at Goodman Hall)
The TBDE CT system enables simultaneous acquisition of high and low kV images in a single scan by splitting the X-ray beam with two filters.  Twin beam spectral CT enables better soft tissue delineation and expanded capabilities for attenuation correction.  CT features include: 128-slice CT with STRATON X-ray tube with 0.3s CT rotation speed, Adaptive Dose shielding and CARE Dose4D, z-Sharp technology for 0.33mm isotropic resolution, iMAR metal artifact reduction, and Adaptive 4D Spiral technology for full-coverage perfusion studies.  

Siemens Biograph mCT (at R2 Building)
CT features include: 128-slice CT with STRATON X-ray tube with 0.3s CT rotation speed, Adaptive Dose shielding and CARE Dose4D, z-Sharp technology for 0.33mm isotropic resolution, iMAR metal artifact reduction, and Adaptive 4D Spiral technology for full-coverage perfusion studies.

Siemens MAGNETOM Prisma 3T MRI (at Goodman Hall)
A research-dedicated Siemens MAGNETOM Prisma 3T 60cm-bore whole-body scanner was installed in August 2014. Key features include: Zero helium boil-off technology, gradient strength up to 80 mT/m at a slew rate up to 200 T/m/s, up to 50 cm FOV; RF system with 64 receive channels supporting up to 204 coil elements; Magnet homogeneity at 40 cm DSV – 0.25 ppm; multiple RF coils including the newly FDA approved 64-channel Head and Neck coil, a 20-channel Head and Neck Coil as well as an array of other anatomy coils (neck, cardiac, shoulder, knee, etc.); Tim 4G +Dot, Tim TX True Shape; Syngo E11C software with InLine Automated Processing; Auto Align slice positioning; Phoenix image reproducibility; Intelligent Coil Control auto coil position detection; full suite of imaging techniques, including multi-nuclear, advanced cardiac, and Syngo advanced neuroimaging applications. The flexible RF system has the capability of performing spectroscopy studies. IDEA and ICE development environment and analysis packages are also available.

Siemens MAGNETOM Prisma Fit 3T MRI (at R2 Building)
A research-dedicated Siemens MAGNETOM Prisma Fit 3T MRI, located in the R2 building, was upgraded in November 2017 and is a 3T whole-body imaging system operating with Syngo software. The system is equipped with a XR Gradients (80 mT/m @ 200 T/m/s) gradient system and 64 independent RF-channels supporting up to 204 coil elements.  Other capabilities are equivalent to the Siemens MAGNETOM Prisma 3T MRI system described above. 

• MRI compatible 4 button in-line response box with fORP interface (Current Designs)
• MRI compatible 2 button trackball (Current Designs)
• fMRI Stimulus Delivery Systems
• Psychology Software Tools, Inc. – DLP Projector System
• Avotec sound system
• Resonance Technolgies VisuaStim System with MRI compatible goggles and headphones
• “Presentation” stimulus delivery software
• Four Windows 64-bit desktops for running stimulus delivery software and equipment
• Two Windows 64-bit laptops for task training and stimulus delivery computer backup

Tau imaging, amyloid imaging, metabolic imaging, perfusion imaging, prostate-specific membrane antigen (PSMA) imaging, neuro-oncologic imaging, dopamine imaging and synaptic density imaging.

Head and neck imaging, musculoskeletal imaging, perfusion imaging, lung imaging and abdominal imaging.

T1-weighted imaging, T2-weighted imaging, T2-FLAIR imaging, diffusion MRI, IVIM MRI, functional MRI, susceptibility-weighted imaging, myelin imaging, arterial-spin labeling (ASL) MRI, dynamic contrast enhanced (DCE) MRI, dynamic susceptibility contrast (DSC) MRI, chemical exchange saturation transfer (CEST) MRI, ultrashort echo time (UTE) MRI, phase contrast imaging, MRI spectroscopy, GABA spectroscopy, glu/glx spectroscopy, P31 spectroscopy, proton density fat fraction (PDFF) and more.

All imaging core studies must register with the Office of Research Imaging (ORI).

Send completed registration form to ORI@iupui.edu

• Prior to opening the study for scheduling, ORI requires a copy of the following study documents:
  • Study protocol
  • Scan protocol or imaging manual
  • IRB number
  • IU account number

Once registered, ORI will review the study and provide an IIBIS ID number for the study. The IIBIS ID number is VERY important to your study, so please keep it with your study materials and make sure all members of the study team working with imaging know it. You must reference this number when scheduling. It will look something like this:

YEAR-00xxx

For studies with nonstandard imaging protocols a study startup meeting is required. Startup meetings are encouraged for all studies to ensure a smooth and successful study.

Please make sure to consider the following when completing your study registration form:

• Does my study require a safety read from a radiologist?
• Do I have all the budgetary information for each imaging procedure?
• Where will the image data be sent?

Once the above information has sent to ori@iupui.edu and has been approved, for scheduling, please contact the imaging technologists:

• resmri@iupui.edu for research MRI scheduling
• respet@iupui.edu for PET/CT scheduling