Faculty Labs

Successful biomedical research demands collaboration among scientists with varying specialties. Faculty investigators throughout IU School of Medicine’s 26 academic departments work together to advance knowledge and treatment for patients in the world’s most critical areas of medicine. These scientists and physician investigators are recognized as the nation’s leading experts in their fields and operate research labs that focus on specialty areas of medical research. Researchers across the school’s nine campuses explore disease and treatment options in exceptional research facilities and are supported with administrative and compliance support.

Anatomy and Cell Biology

The Allen Laboratory is studying the tissue-level mechanisms responsible for musculoskeletal integrity in health and disease by utilizing numerous in vivo model systems that help investigators understand how disease and pharmaceutical intervention influence bone structure, cellular activity, tissue-level properties, and biomechanical properties.

The Bellido Laboratory investigates the mechanisms of signal transduction among and within bone cells, with particular emphasis on the biology of osteocytes.

The Bidwell Lab is exploring improvement of therapies for restoring bone lost to osteoporosis or other diseases.

Research in the Block Laboratory is centered on identifying how microglia, the resident innate immune cells in the brain, can become a chronic source of cytokines and reactive oxygen species that drive progressive neuron damage.

The Bonewald Laboratory focuses on the biology and function of the osteocyte.

The primary area of research for the Burr Lab is to evaluate the effects of pharmacologic agents used to treat osteoporosis on properties associated with quality of the bone matrix.

Research in the Jin Lab focuses on the organization and plasticity of neural circuits in the cerebral cortex, and the mechanisms of epileptogenesis following traumatic brain injury.

The Johnson Lab at IU School of Medicine is investigating the mechanisms of centrally regulated anxiety and panic associated behavior that coincides with cardiorespiratory and thermoregulatory activity.

The Jones Laboratory focuses on neural injury and repair, gonadal steroids as neurotherapeutics, neuroimmunology, and ALS.

The Landreth Lab focuses on the biological basis of Alzheimer’s disease (AD)—specifically, how genetic risks factors influence disease pathogenesis.

The Lasagna-Reeves Lab is studying the role of protein tau in neurodegenerative diseases.

The basic science research in the McNulty Lab focuses on bone and joint pathology. Educational research in this lab centers on improving learning of the anatomical sciences in professional curricula for veterinary, medical and allied health students.

The Organ Lab at IU School of Medicine studies the relationship between bone and muscle mechanics at the whole-organ level, and explores how tissue-level mechanisms influence whole-organ function.

The Plotkin Lab focuses on the role of connexins in the transduction of signals induced by hormonal, pharmacotherapeutic and mechanical stimuli in osteoblasts and osteocytes.

The Robling Laboratory is investigating the molecular mechanisms by which bone tissue senses mechanical loading, by studying how several signal transduction pathways affect bone accumulation and how cellular activity is altered by mechanical stimulation.

The Sankar Laboratory at IU School of Medicine is investigating the mechanisms by which members of the Calcium/calmodulin-dependent protein kinase (CaMK) signaling cascade, CaMKK2 (along with its downstream kinases AMPK, CaMKI and CaMKIV) regulate the fate and function of bone marrow-derived mesenchymal stem cells, osteoblasts and osteoclasts.

The research lab of William A. Truitt, PhD, is focused on determining how social interactions can be used to overcome anxiety. This lab team hopes to contribute to elucidating the neural mechanism by which psychotherapy helps patients overcome anxiety.

The Williams Lab is investigating why kidney stones form and what the bioeffects are of kidney stone removal when using different treatment modalities.

The Xu Lab is studying the role of alteration of neuronal excitability in pathogenesis of neurological disorders.

Biochemistry and Molecular Biology

The Hurley Lab is exploring, at the molecular level, the processes involved in the recognition and binding of molecules that are directed to the active sites of enzymes. Recent work has challenged the team to understand the functional distinction between active site directed inhibitors as well as activators.

Cardiology

Research in the CP Chang Laboratory focuses on defining the molecular mechanisms underlying cardiomyopathy and heart failure and translating bench findings to clinical applications. The lab, led by Ching-Pin Chang, MD, PhD, is staffed by scientists and postdoctoral fellows carrying out research for the Department of Medicine.

The Chen Lab, led by Peng-Sheng Chen, MD, is part of the Krannert Institute of Cardiology, Division of Cardiology, Department of Medicine at IU School of Medicine. The primary interest of the laboratory is to advance science related to cardiac arrhythmias. Members of the laboratory also collaborate widely within the institute and provide basic science support to various basic science and clinical research programs.

Emergency Medicine

Research in the Alves Lab focuses on the interdisciplinary development of translational technologies, treatments and techniques that can be used to have a positive impact on people’s lives. A chemical and bimolecular engineer, Nathan Alves, PhD, encourages researchers to apply engineering principles and designs to create translational technologies for clinical implementation.

Jeff Kline, MD, is a translational researcher in the area of venous thromboembolism, and his lab conducts clinical and applied laboratory research intended to improve the therapeutic index of all steps of venous thromboembolism diagnosis and treatment.

Immunology

The Lobashevsky Lab focuses on Human Leukocyte Antigen (HLA)  studies and performs tests aimed at selecting potential organ donors. The laboratory team also monitors the functional status of patients’ immune cells and tests for paternity.

Microbiology and Immunology

The Broxmeyer Lab focuses on mechanisms regulating proliferation, survival, self-renewal, metabolism, differentiation and homing/mobilization of hematopoietic, embryonic and induced pluripotent stem cells at cellular, intracellular and animal levels.

The Dent Laboratory is focused on the regulation of the immune response by CD4 T helper and regulatory T cells.

The Guo Laboratory focuses on the viral pathogenesis of hepatitis B virus (HBV) and antiviral discovery.

The Kaplan Laboratory focuses on transcription factors that are involved in the development of T helper cell subsets and how those cells contribute to inflammation in allergic and autoimmune diseases.

The Spinola Laboratory focuses on the bacterium Haemophilus ducreyi, which causes cutaneous ulcers in children in the tropics and the genital ulcer disease chancroid, which facilitates the transmission of HIV-1.

The Sullivan Laboratory studies cellular signaling and the regulation of gene expression in a protozoan parasites Plasmodium (malaria) called Toxoplasma.

Ophthalmology

The Corson Lab applies chemical biology to issues relating to eye disease, including age-related macular degeneration and other neovascular eye diseases. The research team is also exploring the biology of and potential therapies for pediatric ocular cancer retinoblastoma.

Orthopaedic Surgery

The Kacena Lab is exploring the interaction of the bone and hematopoietic systems to improve the treatment of metabolic bone disease, hematopoietic disorders and fracture healing.

Psychiatry

The Adams Lab is improving access to high-quality clinical services for children, teens and families impacted by mental health problems and substance use.

Radiology and Imaging Sciences

The Wu Lab studies a wide range of radiology and imaging topics, with a particular focus on diffusion physics in biologic system using diffusion MRI.

Radiation Oncology

The Dynlacht Lab studies the effects of physical and chemical agents that modulate the response of cancer cells and normal tissue to the radiation response, particularly hyperthermia and various chemotherapeutic agents.

The Lautenschlaeger Lab team is working to measure and predict response to radiation therapy in solid tumors with the goal to develop biomarker-guided personalized radiation prescriptions and follow-up care.

Research in the Mendonca Lab is focused on gaining a better understanding of radiation’s ability to both heal and harm.