Matthew R. Allen, PhD
Professor of Anatomy, Cell Biology & Physiology
Bio
Our laboratory studies the tissue-level mechanisms responsible for musculoskeletal integrity in health and disease by utilizing numerous in vivo model systems that help investigators understand how disease and pharmaceutical intervention influence bone structure, cellular activity, tissue-level properties (such as mineralization, microdamage, collagen, hydration), and biomechanical properties.
The laboratory studies a range of diseases/conditions, including osteoporosis, chronic kidney disease, and disuse using techniques that include imaging (CT, DXA, X-ray), histology (static and dynamic histomorphometry, microdamage), and mechanical testing (bending, compression, fatigue loading).
Titles & Appointments
- Professor of Anatomy, Cell Biology & Physiology
- Adjunct Professor of Medicine
- Adjunct Professor of Orthopaedic Surgery
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Education2003 PhD Texas A&M University1998 BS Alma College
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Research
Treating skeletal complications of chronic kidney disease
NIH/NIAMS-funded project: One in ten Americans suffers from chronic kidney disease (CKD). Individuals with end-stage CKD have a 17-fold higher risk of skeletal fracture than the normal population and of CKD patients that sustain a hip fracture over 60% die within a year (compared to 20% in the normal population). Our work in this field is focused on gaining a greater understanding of the underlying skeletal schanges associated with CKD and finding a viable treatment for these changes. This work is done in collaboration with Dr. Sharon Moe, a clinical nephrologist.
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PublicationsPreclinical Models for Skeletal Research: How Commonly Used Species Mimic (or Don't) Aspects of Human Bone.
Allen MR; Toxicologic pathology 2017 Sep 25Corrigendum to "Even with rehydration, preservation in ethanol influences the mechanical properties of bone and how bone responds to experimental manipulation" [Bone 97 (2017) 49-53].
Vesper EO; Hammond MA; Allen MR; Wallace JM; Bone 2017 Sep 18Improving Combination Osteoporosis Therapy in a Preclinical Model of Heightened Osteoanabolism.
Shao Y; Hernandez-Buquer S; Childress P; Stayrook KR; Alvarez MB; Davis H; Plotkin LI; He Y; Condon KW; Burr DB; Warden SJ; Robling AG; Yang FC; Wek RC; Allen MR; Bidwell JP; Endocrinology 2017 Sep 1Incorporating tissue anisotropy and heterogeneity in finite element models of trabecular bone altered predicted local stress distributions.
Hammond MA; Wallace JM; Allen MR; Siegmund T; Biomechanics and modeling in mechanobiology 2017 Nov 14Effects of daily restraint with and without injections on skeletal properties in C57BL/6NHsd mice.
Larsen RA; Peveler JL; Klutzke JB; Hickman DL; Aref MW; Wallace JM; Brown DM; Allen MR; Lab animal 2017 Jun 23What Animal Models Have Taught Us About the Safety and Efficacy of Bisphosphonates in Chronic Kidney Disease.
Allen MR; Aref MW; Current osteoporosis reports 2017 JunRad GTPase is essential for the regulation of bone density and bone marrow adipose tissue in mice.
Withers CN; Brown DM; Byiringiro I; Allen MR; Condon KW; Satin J; Andres DA; Bone 2017 Jul 18Even with rehydration, preservation in ethanol influences the mechanical properties of bone and how bone responds to experimental manipulation.
Vesper EO; Hammond MA; Allen MR; Wallace JM; Bone 2017 Jan 3Raloxifene Improves Bone Mechanical Properties in Mice Previously Treated with Zoledronate.
Meixner CN; Aref MW; Gupta A; McNerny EMB; Brown D; Wallace JM; Allen MR; Calcified tissue international 2017 Feb 28Effects of combination treatment with alendronate and raloxifene on skeletal properties in a beagle dog model.
Allen MR; McNerny E; Aref M; Organ JM; Newman CL; McGowan B; Jang T; Burr DB; Brown DM; Hammond M; Territo PR; Lin C; Persohn S; Jiang L; Riley AA; McCarthy BP; Hutchins GD; Wallace JM; PloS one 2017 Aug 9Exposure to Low-Dose X-Ray Radiation Alters Bone Progenitor Cells and Bone Microarchitecture.
Lima F; Swift JM; Greene ES; Allen MR; Cunningham DA; Braby LA; Bloomfield SA; Radiation research 2017 Aug 3The fracture toughness of small animal cortical bone measured using arc-shaped tension specimens: Effects of bisphosphonate and deproteinization treatments.
Hunckler MD; Chu ED; Baumann AP; Curtis TE; Ravosa MJ; Allen MR; Roeder RK; Bone 2017 Aug 18Assessment of regional bone tissue perfusion in rats using fluorescent microspheres.
Aref MW; Akans E; Allen MR; Bone reports 2017 Apr 26PTHrP-Derived Peptides Restore Bone Mass and Strength in Diabetic Mice: Additive Effect of Mechanical Loading.
Maycas M; McAndrews KA; Sato AY; Pellegrini GG; Brown DM; Allen MR; Plotkin LI; Gortazar AR; Esbrit P; Bellido T; Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2016 Oct 24Conditional Deletion of Murine Fgf23: Interruption of the Normal Skeletal Responses to Phosphate Challenge and Rescue of Genetic Hypophosphatemia.
Clinkenbeard EL; Cass TA; Ni P; Hum JM; Bellido T; Allen MR; White KE; Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2016 Mar 4Protection From Glucocorticoid-Induced Osteoporosis by Anti-Catabolic Signaling in the Absence of Sost/Sclerostin.
Sato AY; Cregor M; Delgado-Calle J; Condon KW; Allen MR; Peacock M; Plotkin LI; Bellido T; Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2016 Jun 5Zoledronate treatment has different effects in mouse strains with contrasting baseline bone mechanical phenotypes.
Aref MW; McNerny EM; Brown D; Jepsen KJ; Allen MR; Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA 2016 Jul 20Corrigendum to "Structural features underlying raloxifene's biophysical interaction with bone matrix" [Bioorg. Med. Chem. 24 (2016) 759-767].
Bivi N; Hu H; Chavali B; Chalmers MJ; Reutter CT; Durst GL; Riley A; Sato M; Allen MR; Burr DB; Dodge JA; Bioorganic & medicinal chemistry 2016 Jul 14Raloxifene improves skeletal properties in an animal model of cystic chronic kidney disease.
Newman CL; Creecy A; Granke M; Nyman JS; Tian N; Hammond MA; Wallace JM; Brown DM; Chen N; Moe SM; Allen MR; Kidney international 2016 Jan 4Assessing the inter- and intra-animal variability of <i>in vivo</i> OsteoProbe skeletal measures in untreated dogs.
McNerny EM; Organ JM; Wallace JM; Newman CL; Brown DM; Allen MR; Bone reports 2016 Aug 8Skeletal Muscle Regeneration and Oxidative Stress Are Altered in Chronic Kidney Disease.
Avin KG; Chen NX; Organ JM; Zarse C; O'Neill K; Conway RG; Konrad RJ; Bacallao RL; Allen MR; Moe SM; PloS one 2016 Aug 3Simulating the Lunar Environment: Partial Weightbearing and High-LET Radiation-Induce Bone Loss and Increase Sclerostin-Positive Osteocytes.
Macias BR; Lima F; Swift JM; Shirazi-Fard Y; Greene ES; Allen MR; Fluckey J; Hogan HA; Braby L; Wang S; Bloomfield SA; Radiation research 2016 Aug 18Reference point indentation is insufficient for detecting alterations in traditional mechanical properties of bone under common experimental conditions.
Krege JB; Aref MW; McNerny E; Wallace JM; Organ JM; Allen MR; Bone 2016 Apr 9Defective cancellous bone structure and abnormal response to PTH in cortical bone of mice lacking Cx43 cytoplasmic C-terminus domain.
Pacheco-Costa R; Davis HM; Sorenson C; Hon MC; Hassan I; Reginato RD; Allen MR; Bellido T; Plotkin LI; Bone 2015 Sep 26Response to Comments on "True Gold or Pyrite: A Review of Reference Point Indentation for Assessing Bone Mechanical Properties In Vivo".
Allen MR; McNerny EM; Organ JM; Wallace JM; Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2015 Sep 16Skin wound trauma, following high-dose radiation exposure, amplifies and prolongs skeletal tissue loss.
Swift JM; Swift SN; Smith JT; Kiang JG; Allen MR; Bone 2015 Sep 1Reduced skeletal muscle function is associated with decreased fiber cross-sectional area in the Cy/+ rat model of progressive kidney disease.
Organ JM; Srisuwananukorn A; Price P; Joll JE; Biro KC; Rupert JE; Chen NX; Avin KG; Moe SM; Allen MR; Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 2015 Oct 5Effects of spaceflight on the murine mandible: Possible factors mediating skeletal changes in non-weight bearing bones of the head.
Ghosh P; Stabley JN; Behnke BJ; Allen MR; Delp MD; Bone 2015 Nov 9In Vivo UTE-MRI Reveals Positive Effects of Raloxifene on Skeletal-Bound Water in Skeletally Mature Beagle Dogs.
Allen MR; Territo PR; Lin C; Persohn S; Jiang L; Riley AA; McCarthy BP; Newman CL; Burr DB; Hutchins GD; Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2015 May 21Foreword: Calcified Tissue International and Musculoskeletal Research Special Issue: Bone Material Properties and Skeletal Fragility.
Burr DB; Allen MR; Calcified tissue international 2015 May 13Influence of Zoledronic Acid on Atrial Electrophysiological Parameters and Electrocardiographic Measurements.
Tisdale JE; Allen MR; Overholser BR; Jaynes HA; Kovacs RJ; Journal of cardiovascular electrophysiology 2015 Mar 31Response to Courtney et al.
Bajaj D; Geissler JR; Allen MR; Burr DB; Fritton JC; Bone 2015 Mar 24Anti-sclerostin antibody treatment in a rat model of progressive renal osteodystrophy.
Moe SM; Chen NX; Newman CL; Organ JM; Kneissel M; Kramer I; Gattone VH 2nd; Allen MR; Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2015 MarIn vivo reference point indentation measurement variability in skeletally mature inbred mice.
Srisuwananukorn A; Allen MR; Brown DM; Wallace JM; Organ JM; BoneKEy reports 2015 Jun 17Inhibition of osteocyte apoptosis prevents the increase in osteocytic receptor activator of nuclear factor ?B ligand (RANKL) but does not stop bone resorption or the loss of bone induced by unloading.
Plotkin LI; Gortazar AR; Davis HM; Condon KW; Gabilondo H; Maycas M; Allen MR; Bellido T; The Journal of biological chemistry 2015 Jun 17Low Bone Turnover in Chronic Kidney Disease Is Associated with Decreased VEGF-A Expression and Osteoblast Differentiation.
Chen NX; O'Neill KD; Allen MR; Newman CL; Moe SM; American journal of nephrology 2015 Jul 25Effects of skeletal unloading on the vasomotor properties of the rat femur principal nutrient artery.
Prisby RD; Behnke BJ; Allen MR; Delp MD; Journal of applied physiology (Bethesda, Md. : 1985) 2015 Jan 29Development of an in vivo rabbit ulnar loading model.
Baumann AP; Aref MW; Turnbull TL; Robling AG; Niebur GL; Allen MR; Roeder RK; Bone 2015 Feb 12Structural features underlying raloxifene's biophysical interaction with bone matrix.
Bivi N; Hu H; Chavali B; Chalmers MJ; Reutter CT; Durst GL; Riley A; Sato M; Allen MR; Burr DB; Dodge JA; Bioorganic & medicinal chemistry 2015 Dec 29Raloxifene reduces skeletal fractures in an animal model of osteogenesis imperfecta.
Berman AG; Wallace JM; Bart ZR; Allen MR; Matrix biology : journal of the International Society for Matrix Biology 2015 Dec 18True Gold or Pyrite: A Review of Reference Point Indentation for Assessing Bone Mechanical Properties In Vivo.
Allen MR; McNerny EM; Organ JM; Wallace JM; Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2015 Aug 6Alendronate treatment alters bone tissues at multiple structural levels in healthy canine cortical bone.
Acevedo C; Bale H; Gludovatz B; Wat A; Tang SY; Wang M; Busse B; Zimmermann EA; Schaible E; Allen MR; Burr DB; Ritchie RO; Bone 2015 Aug 5Genome-Wide Mapping and Interrogation of the Nmp4 Antianabolic Bone Axis.
Childress P; Stayrook KR; Alvarez MB; Wang Z; Shao Y; Hernandez-Buquer S; Mack JK; Grese ZR; He Y; Horan D; Pavalko FM; Warden SJ; Robling AG; Yang FC; Allen MR; Krishnan V; Liu Y; Bidwell JP; Molecular endocrinology (Baltimore, Md.) 2015 Aug 5Medication-Related Osteonecrosis of the Jaw: Basic and Translational Science Updates.
Allen MR; Oral and maxillofacial surgery clinics of North America 2015 Aug 13Compromised vertebral structural and mechanical properties associated with progressive kidney disease and the effects of traditional pharmacological interventions.
Newman CL; Chen NX; Smith E; Smith M; Brown D; Moe SM; Allen MR; Bone 2015 Apr 17Beta-1 adrenergic agonist treatment mitigates negative changes in cancellous bone microarchitecture and inhibits osteocyte apoptosis during disuse.
Swift JM; Swift SN; Allen MR; Bloomfield SA; PloS one 2014 Sep 11Duration-dependent effects of clinically relevant oral alendronate doses on cortical bone toughness in beagle dogs.
Burr DB; Liu Z; Allen MR; Bone 2014 Oct 23Variability of in vivo reference point indentation in skeletally mature inbred rats.
Allen MR; Newman CL; Smith E; Brown DM; Organ JM; Journal of biomechanics 2014 May 8Parathyroid hormone receptor signaling induces bone resorption in the adult skeleton by directly regulating the RANKL gene in osteocytes.
Ben-awadh AN; Delgado-Calle J; Tu X; Kuhlenschmidt K; Allen MR; Plotkin LI; Bellido T; Endocrinology 2014 May 30Pathogenesis of arrhythmias in a model of CKD.
Hsueh CH; Chen NX; Lin SF; Chen PS; Gattone VH 2nd; Allen MR; Fishbein MC; Moe SM; Journal of the American Society of Nephrology : JASN 2014 May 22Cortical bone mechanical properties are altered in an animal model of progressive chronic kidney disease.
Newman CL; Moe SM; Chen NX; Hammond MA; Wallace JM; Nyman JS; Allen MR; PloS one 2014 Jun 9Genetic rescue of glycosylation-deficient Fgf23 in the Galnt3 knockout mouse.
Ichikawa S; Gray AK; Padgett LR; Allen MR; Clinkenbeard EL; Sarpa NM; White KE; Econs MJ; Endocrinology 2014 Jul 22Bone cell-independent benefits of raloxifene on the skeleton: a novel mechanism for improving bone material properties.
Gallant MA; Brown DM; Hammond M; Wallace JM; Du J; Deymier-Black AC; Almer JD; Stock SR; Allen MR; Burr DB; Bone 2014 Jan 24High bone mass in mice lacking Cx37 because of defective osteoclast differentiation.
Pacheco-Costa R; Hassan I; Reginato RD; Davis HM; Bruzzaniti A; Allen MR; Plotkin LI; The Journal of biological chemistry 2014 Feb 7Neonatal iron deficiency causes abnormal phosphate metabolism by elevating FGF23 in normal and ADHR mice.
Clinkenbeard EL; Farrow EG; Summers LJ; Cass TA; Roberts JL; Bayt CA; Lahm T; Albrecht M; Allen MR; Peacock M; White KE; Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2014 FebTreatment with eldecalcitol positively affects mineralization, microdamage, and collagen crosslinks in primate bone.
Saito M; Grynpas MD; Burr DB; Allen MR; Smith SY; Doyle N; Amizuka N; Hasegawa T; Kida Y; Marumo K; Saito H; Bone 2014 Dec 5Changes in skeletal collagen cross-links and matrix hydration in high- and low-turnover chronic kidney disease.
Allen MR; Newman CL; Chen N; Granke M; Nyman JS; Moe SM; Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA 2014 Dec 3The resistance of cortical bone tissue to failure under cyclic loading is reduced with alendronate.
Bajaj D; Geissler JR; Allen MR; Burr DB; Fritton JC; Bone 2014 Apr 1A comparison of calcium to zoledronic acid for improvement of cortical bone in an animal model of CKD.
Moe SM; Chen NX; Newman CL; Gattone VH 2nd; Organ JM; Chen X; Allen MR; Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2014 AprA novel approach to evaluate the effect of medicaments used in endodontic regeneration on root canal surface indentation.
Yassen GH; Chu TM; Gallant MA; Allen MR; Vail MM; Murray PE; Platt JA; Clinical oral investigations 2013 Oct 8Adverse mandibular bone effects associated with kidney disease are only partially corrected with bisphosphonate and/or calcium treatment.
Allen MR; Chen NX; Gattone VH 2nd; Moe SM; American journal of nephrology 2013 Nov 22Partial weight bearing does not prevent musculoskeletal losses associated with disuse.
Swift JM; Lima F; Macias BR; Allen MR; Greene ES; Shirazi-Fard Y; Kupke JS; Hogan HA; Bloomfield SA; Medicine and science in sports and exercise 2013 NovDecreased microRNA is involved in the vascular remodeling abnormalities in chronic kidney disease (CKD).
Chen NX; Kiattisunthorn K; O'Neill KD; Chen X; Moorthi RN; Gattone VH 2nd; Allen MR; Moe SM; PloS one 2013 May 22Bisphosphonate-induced reductions in rat femoral bone energy absorption and toughness are testing rate-dependent.
Smith ER; Allen MR; Journal of orthopaedic research : official publication of the Orthopaedic Research Society 2013 Mar 13Short-courses of dexamethasone abolish bisphosphonate-induced reductions in bone toughness.
Luo TD; Allen MR; Bone 2013 Jun 14In vivo reference point indentation reveals positive effects of raloxifene on mechanical properties following 6 months of treatment in skeletally mature beagle dogs.
Aref M; Gallant MA; Organ JM; Wallace JM; Newman CL; Burr DB; Brown DM; Allen MR; Bone 2013 Jul 17Absence of exposed bone following dental extraction in beagle dogs treated with 9 months of high-dose zoledronic acid combined with dexamethasone.
Allen MR; Chu TM; Ruggiero SL; Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons 2013 Feb 1The Rho-GEF Kalirin regulates bone mass and the function of osteoblasts and osteoclasts.
Huang S; Eleniste PP; Wayakanon K; Mandela P; Eipper BA; Mains RE; Allen MR; Bruzzaniti A; Bone 2013 Dec 28Circulating aKlotho influences phosphate handling by controlling FGF23 production.
Smith RC; O'Bryan LM; Farrow EG; Summers LJ; Clinkenbeard EL; Roberts JL; Cass TA; Saha J; Broderick C; Ma YL; Zeng QQ; Kharitonenkov A; Wilson JM; Guo Q; Sun H; Allen MR; Burr DB; Breyer MD; White KE; The Journal of clinical investigation 2012 Nov 26Cell autonomous requirement of connexin 43 for osteocyte survival: consequences for endocortical resorption and periosteal bone formation.
Bivi N; Condon KW; Allen MR; Farlow N; Passeri G; Brun LR; Rhee Y; Bellido T; Plotkin LI; Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2012 FebReference-point indentation correlates with bone toughness assessed using whole-bone traditional mechanical testing.
Gallant MA; Brown DM; Organ JM; Allen MR; Burr DB; Bone 2012 Dec 27Orthodontic mini-implant diameter does not affect in-situ linear microcrack generation in the mandible or the maxilla.
Liu SS; Cruz-Marroquin E; Sun J; Stewart KT; Allen MR; American journal of orthodontics and dentofacial orthopedics : official publication of the American Association of Orthodontists, its constituent societies, and the American Board of Orthodontics 2012 DecSkeletal effects of zoledronic acid in an animal model of chronic kidney disease.
Allen MR; Chen NX; Gattone VH 2nd; Chen X; Carr AJ; LeBlanc P; Brown D; Moe SM; Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA 2012 Aug 21Sost downregulation and local Wnt signaling are required for the osteogenic response to mechanical loading.
Tu X; Rhee Y; Condon KW; Bivi N; Allen MR; Dwyer D; Stolina M; Turner CH; Robling AG; Plotkin LI; Bellido T; Bone 2011 Oct 30Dietary phosphate restriction normalizes biochemical and skeletal abnormalities in a murine model of tumoral calcinosis.
Ichikawa S; Austin AM; Gray AK; Allen MR; Econs MJ; Endocrinology 2011 Oct 18Iron deficiency drives an autosomal dominant hypophosphatemic rickets (ADHR) phenotype in fibroblast growth factor-23 (Fgf23) knock-in mice.
Farrow EG; Yu X; Summers LJ; Davis SI; Fleet JC; Allen MR; Robling AG; Stayrook KR; Jideonwo V; Magers MJ; Garringer HJ; Vidal R; Chan RJ; Goodwin CB; Hui SL; Peacock M; White KE; Proceedings of the National Academy of Sciences of the United States of America 2011 Oct 17Bisphosphonates do not alter the rate of secondary mineralization.
Fuchs RK; Faillace ME; Allen MR; Phipps RJ; Miller LM; Burr DB; Bone 2011 May 18PTH receptor signaling in osteocytes governs periosteal bone formation and intracortical remodeling.
Rhee Y; Allen MR; Condon K; Lezcano V; Ronda AC; Galli C; Olivos N; Passeri G; O'Brien CA; Bivi N; Plotkin LI; Bellido T; Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2011 MayThe effects of bisphosphonates on jaw bone remodeling, tissue properties, and extraction healing.
Allen MR; Odontology 2011 Jan 27In vivo effects of zoledronic acid on oral mucosal epithelial cells.
Allam E; Allen M; Chu TM; Ghoneima A; Jack Windsor L; Oral diseases 2010 Sep 23Bisphosphonate effects on bone turnover, microdamage, and mechanical properties: what we think we know and what we know that we don't know.
Allen MR; Burr DB; Bone 2010 Oct 16Lack of correlation between duration of osteonecrosis of the jaw and sequestra tissue morphology: what it tells us about the condition and what it means for future studies.
Allen MR; Pandya B; Ruggiero SL; Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons 2010 NovMethodological assessment of acid-etching for visualizing the osteocyte lacunar-canalicular networks using scanning electron microscopy.
Kubek DJ; Gattone VH 2nd; Allen MR; Microscopy research and technique 2010 MarGreater magnitude of turnover suppression occurs earlier after treatment initiation with risedronate than alendronate.
Allen MR; Turek JJ; Phipps RJ; Burr DB; Bone 2010 Jul 15Cancer treatment dosing regimens of zoledronic acid result in near-complete suppression of mandible intracortical bone remodeling in beagle dogs.
Allen MR; Kubek DJ; Burr DB; Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2010 JanBisphosphonates do not inhibit periosteal bone formation in estrogen deficient animals and allow enhanced bone modeling in response to mechanical loading.
Feher A; Koivunemi A; Koivunemi M; Fuchs RK; Burr DB; Phipps RJ; Reinwald S; Allen MR; Bone 2009 Oct 24Effects of 1 to 3 years' treatment with alendronate on mechanical properties of the femoral shaft in a canine model: implications for subtrochanteric femoral fracture risk.
Burr DB; Diab T; Koivunemi A; Koivunemi M; Allen MR; Journal of orthopaedic research : official publication of the Orthopaedic Research Society 2009 OctThe pathogenesis of bisphosphonate-related osteonecrosis of the jaw: so many hypotheses, so few data.
Allen MR; Burr DB; Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons 2009 MayHigher bone matrix density exists in only a subset of patients with bisphosphonate-related osteonecrosis of the jaw.
Allen MR; Ruggiero SL; Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons 2009 JulSkeletal changes associated with the onset of type 2 diabetes in the ZDF and ZDSD rodent models.
Reinwald S; Peterson RG; Allen MR; Burr DB; American journal of physiology. Endocrinology and metabolism 2009 Jan 21Morphological assessment of basic multicellular unit resorption parameters in dogs shows additional mechanisms of bisphosphonate effects on bone.
Allen MR; Erickson AM; Wang X; Burr DB; Martin RB; Hazelwood SJ; Calcified tissue international 2009 Dec 2Mandibular necrosis in beagle dogs treated with bisphosphonates.
Burr DB; Allen MR; Orthodontics & craniofacial research 2009 AugSkeletal accumulation of bisphosphonates: implications for osteoporosis treatment.
Allen MR; Expert opinion on drug metabolism & toxicology 2008 NovAlendronate reduces bone toughness of ribs without significantly increasing microdamage accumulation in dogs following 3 years of daily treatment.
Allen MR; Reinwald S; Burr DB; Calcified tissue international 2008 May 8Mandible matrix necrosis in beagle dogs after 3 years of daily oral bisphosphonate treatment.
Allen MR; Burr DB; Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons 2008 MayAlendronate treatment results in similar levels of trabecular bone remodeling in the femoral neck and vertebra.
Diab T; Allen MR; Burr DB; Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA 2008 Aug 21Bisphosphonates and osteonecrosis of the jaw: moving from the bedside to the bench.
Allen MR; Cells, tissues, organs 2008 Aug 13Strontium ranelate does not stimulate bone formation in ovariectomized rats.
Fuchs RK; Allen MR; Condon KW; Reinwald S; Miller LM; McClenathan D; Keck B; Phipps RJ; Burr DB; Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA 2008 Apr 3Three years of alendronate treatment results in similar levels of vertebral microdamage as after one year of treatment.
Allen MR; Burr DB; Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2007 NovRaloxifene enhances material-level mechanical properties of femoral cortical and trabecular bone.
Allen MR; Hogan HA; Hobbs WA; Koivuniemi AS; Koivuniemi MC; Burr DB; Endocrinology 2007 May 3In situ examination of the time-course for secondary mineralization of Haversian bone using synchrotron Fourier transform infrared microspectroscopy.
Fuchs RK; Allen MR; Ruppel ME; Diab T; Phipps RJ; Miller LM; Burr DB; Matrix biology : journal of the International Society for Matrix Biology 2007 Jul 27Bisphosphonates alter trabecular bone collagen cross-linking and isomerization in beagle dog vertebra.
Allen MR; Gineyts E; Leeming DJ; Burr DB; Delmas PD; Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA 2007 Dec 18Mechanical stimulation of bone in vivo reduces osteocyte expression of Sost/sclerostin.
Robling AG; Niziolek PJ; Baldridge LA; Condon KW; Allen MR; Alam I; Mantila SM; Gluhak-Heinrich J; Bellido TM; Harris SE; Turner CH; The Journal of biological chemistry 2007 Dec 17Changes in vertebral strength-density and energy absorption-density relationships following bisphosphonate treatment in beagle dogs.
Allen MR; Burr DB; Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA 2007 Aug 21Antiremodeling agents influence osteoblast activity differently in modeling and remodeling sites of canine rib.
Allen MR; Follet H; Khurana M; Sato M; Burr DB; Calcified tissue international 2006 Oct 10Raloxifene enhances vertebral mechanical properties independent of bone density.
Allen MR; Iwata K; Sato M; Burr DB; Bone 2006 Jun 30Human femoral neck has less cellular periosteum, and more mineralized periosteum, than femoral diaphyseal bone.
Allen MR; Burr DB; Bone 2005 FebPeriosteum: biology, regulation, and response to osteoporosis therapies.
Allen MR; Hock JM; Burr DB; Bone 2004 Nov
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