22606-Alves, Nathan

Nathan J. Alves, MS, PhD

Associate Professor of Emergency Medicine

FT FOB 3rd Floor
Indianapolis, IN
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Dr. Nathan J. Alves received his PhD in Chemical and Biomolecular Engineering from the University of Notre Dame.  Following graduate school, he completed a post-doctoral research fellowship at the IU School of Medicine, where he began his work on the pharmaceutical delivery of clot-digesting enzymes utilizing a nanoparticle-based delivery system. He then spent two years at the Naval Research Laboratory (NRL) in DC on a National Academy of Science Research Associateship. Currently, Dr. Alves is the Director of Translational Research and an Associate Professor at the Indiana University School of Medicine (IUSM) in the Department of Emergency Medicine with a joint appointment at Purdue University in Biomedical Engineering.  The research he conducts, while spanning many disciplines, is centered on the development of translational technologies, treatments, and techniques that can be utilized to have a positive impact on people’s lives.  He has extensive experience in: nanoparticle drug delivery, packaging of pharmaceutical agents/enzymes to treat various diseases, studying the effect that microplastic exposure has on coagulation and fibrinolysis, site-specific antibody modification, oriented antibody immobilization for advanced diagnostics, and extracellular vesicles (EV).  His multidisciplinary background affords him a unique perspective to tackle complex therapeutic and medical device development problems. 

Key Publications

  1. Zeng Z., Christodoulides A., Alves N. J. (2023). Real-time Tracking of Fibrinolysis Under Constant Wall Shear and Various Pulsatile Flows in an in-vitro Thrombolysis Model. Bioengineering & Translational Medicine, e10511, doi:10.1002/btm2.10511.
  2. Nallan Chakravarthula T., Zeng Z., Alves N. J. (2022). Multivalent Benzamidine Molecules for Plasmin Inhibition: Effect of Valency and Linker Length. ChemMedChem17(22), e202200364.
  3. Zeng Z., Chakravarthula T. N., Muralidharan C., Hall A., Linnemann A. K., Alves, N. J. (2021). A Unique Fluorescently Labeled Annular Clot Lysis Assay for Diagnostic and Drug Development Applications. Royal Society of Chemistry: Journal of Materials Chemistry B, 9(45), 9295-9307.~featured on cover.
  4. Lett Z., Hall A., Skidmore S., Alves N. J. (2021). Environmental Microplastic and Nanoplastic: Exposure Routes and Effects on Coagulation and the Cardiovascular System. Environmental Pollution291, 118190.
  5. Alves, N. J., Turner, K. B., Daniele, M. A., Oh, E., Medintz, I. L., & Walper, S. A. (2015). Bacterial Nanobioreactors-Directing Enzyme Packaging into Bacterial Outer Membrane Vesicles. ACS Applied Materials & Interfaces, 7(44), 24963-24972.
  6. Alves N. J., Mustafaoglu N., Bilgicer B. (2013). Oriented antibody immobilization by site-specific UV photocrosslinking of biotin at the conserved nucleotide binding site for enhanced antigen detection. Biosensors and Bioelectronics, 49, 387-393.
  7. Paraskar A.S., Son, S., Chin K.T., Chaudhuri P., Muto K.W., Berkowitz J., Handlogten M.W., Alves N.J., Bilgicer B., Dinulescu D.M., Mashelkar R.A. (2010). Harnessing structure-activity relationship to engineer a cisplatin nanoparticle for enhanced antitumor efficacy. Proceedings of the National Academy of Sciences107(28), pp.12435-12440.

Titles & Appointments

  • Associate Professor of Emergency Medicine
  • Adjunct Associate Professor of Anatomy, Cell Biology & Physiology
  • Adjunct Associate Professor of Biochemistry & Molecular Biology
  • Director of Translational Research, Emergency Medicine
  • Assistant Professor of Biomedical Engineering, Purdue University
  • Education
    2013 PhD University of Notre Dame
    2011 MS University of Notre Dame
    2008 MS University of Rochester
    2007 BS University of Rochester
  • Research

    As a chemical and biomolecular engineer, I love conducting research at the interface of science, engineering, and medicine.  I am particularly driven to develop translational solutions to real-world clinical problems. This goal is achieved through collaborative research initiates, publication, and patent filings.  The following are my areas of active interest:

    -Developing safter direct fibrinolytic therapeutics to effectively digest blood clots while limiting bleeding risk.

    -Creating high fidelity in-vivo like blood clots with reproducible clot architecture.

    -Establish an ex-vivo testing platform for assessing novel clot digesting therapeutics under flow at physiologically relevant length scales. 

    -Identify how multivalency can be leveraged to modulate enzyme activity in the body. 

    -Studying the effects of microplastic and nanoplastic exposure on coagulation and fibrinolysis through various routes of exposure.

  • Professional Organizations
    American Association for the Advancement of Science
    American Chemical Society
    Biomedical Engineering Society
    National Blood Clot Alliance; Medical and Scientific Advisory Board
    Society of Academic Emergency Medicine
    The Antibody Society; Scientific Advisor
  • Awards
    Org: BioCrossroads
    Desc: Inaugural 23 PAIR (Promising Achiever in Innovation and Research) Recipient
    Scope: State
    Date: 2022-03-01
    Org: IUPUI
    Desc: Translating Research into Practice (TRIP) Scholar
    Scope: Campus
    Date: 2017-01-01
    Org: National Academies of Science, Engineering, and Medicine
    Desc: National Research Council (NRC) Post-Doctoral Research Associateship
    Scope: National
    Date: 2014-01-01
    Org: Baxter
    Desc: Baxter Young Investigator Award as an Up-and-Coming Mind in Science
    Scope: National
    Date: 2013-01-01
    Org: Autumn Immunology Conference
    Desc: John H. Wallace Diversity Fellow
    Scope: Regional
    Date: 2013-01-01
    Org: University of Notre Dame
    Desc: Notebaert Professional Development Grant
    Scope: Campus
    Date: 2012-01-01

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