Nathan J. Alves, MS, PhD

Bio

Dr. Nathan J. Alves received his PhD in Chemical and Biomolecular Engineering from the University of Notre Dame. Following graduate school, he completed a post-doctoral research fellowship at the IU School of Medicine, where he began his work on the pharmaceutical delivery of clot-digesting enzymes utilizing a nanoparticle-based delivery system. He then spent two years at the Naval Research Labroatory (NRL) in DC on a National Academy of Science Research Associateship. Currently, Dr. Alves is the Director of Translational Research and an Assistant Professor at the Indiana University School of Medicine (IUSM) in the Department of Emergency Medicine with a joint appointment at Purdue University in Biomedical Engineering. The research he conducts, while spanning many disciplines, is centered on the development of translational technologies, treatments, and techniques that can be utilized to have a positive impact on people’s lives. He has extensive experience in: site-specific antibody modification, oriented antibody immobilization for advanced diagnostics, nanoparticle delivery, and packaging of pharmaceutical agents/enzymes to treat various diseases. His multidisciplinary background affords him a unique perspective to tackle complex therapeutic and medical device development problems.

Titles & Appointments

Associate Professor of Emergency Medicine
Adjunct Associate Professor of Anatomy, Cell Biology & Physiology
Adjunct Associate Professor of Biochemistry & Molecular Biology
Director of Translational Research, Emergency Medicine
Assistant Professor of Biomedical Engineering, Purdue University

Education

2013 PhD University of Notre Dame

2011 MS University of Notre Dame

2008 MS University of Rochester

2007 BS University of Rochester
Research

As a chemical and biomolecular engineer, I love conducting research at the interface of science, engineering, and medicine. I am particularly driven to develop translational solutions to real-world clinical problems. This goal is achieved through collaborative research initiates, publication, and patent filings. The following are my areas of active interest:

-Developing safter direct fibrinolytic therapeutics to effectively digest blood clots while limiting bleeding risk.

-Creating high fidelity in-vivo like blood clots with reproducible clot architecture.

-Establish an ex-vivo testing platform for assessing novel clot digesting therapeutics under flow at physiologically relevant length scales.

-Identify how multivalency can be leveraged to modulate enzyme activity in the body.
Professional Organizations

American Association for the Advancement of Science

American Chemical Society

Biomedical Engineering Society

National Blood Clot Alliance; Medical and Scientific Advisory Board

Society of Academic Emergency Medicine

The Antibody Society; Scientific Advisor
Awards

Org: IUPUI
Desc: Translating Research into Practice (TRIP) Scholar
Scope: Campus
Date: 2017-01-01

Org: National Academies of Science, Engineering, and Medicine
Desc: National Research Council (NRC) Post-Doctoral Research Associateship
Scope: National
Date: 2014-01-01

Org: Baxter International
Desc: Young Investigator Award as an Up-and-Coming Mind in Science
Scope: National
Date: 2013-01-01

Org: Baxter International
Desc: Young Investigator Award as an Up-and-Coming Mind in Science
Scope: National
Date: 2013-01-01

Org: Baxter International
Desc: Young Investigator Award
Scope: National
Date: 2013-01-01

Org: Autumn Immunology Conference
Desc: John H. Wallace Diversity Fellow
Scope: Regional
Date: 2013-01-01

Org: The Antibody Society
Desc: Student Scholarship
Scope: International
Date: 2012-01-01

Org: University of Notre Dame
Desc: Notebaert Professional Development Grant
Scope: Campus
Date: 2012-01-01

Org: Gordon Research Conferences
Desc: Carl Storm Underrepresented Minority Fellowship
Scope: National
Date: 2012-01-01

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Faculty Labs