Aronoff Lab

The Aronoff Lab studies host-microbial interactions with an emphasis on bacterial infections and innate immunity. Our microbiology and immunology research centers primarily on the female reproductive tract, specifically at the maternal-fetal interface during pregnancy. We focus our work on the placenta and isolated innate immune cells, mainly macrophages. We are interested in fetal versus maternal macrophages and how each might contribute to protecting the fetus during infections throughout pregnancy. Some of the macrophage functions we study include:

  • Receptor-mediated recognition and phagocytosis of bacteria
  • Mechanisms of intracellular killing of bacteria
  • The production of inflammatory mediators (e.g., cytokines, chemokines, and lipids)

Our microbiological studies focus on the Gram positive bacterium Streptococcus agalactiae (Group B Streptococcus; GBS), the bacterium that roughly 30% of women of child-bearing age carry rectovaginally and can sometimes result in pregnancy complications.

Some of the lab techniques we commonly perform include:

  • RNA analysis via qRT-PCR, and scRNA methods including tissue-level spatial transcriptomics
  • Protein analysis via western blotting, ELISA, multiplexing bead-arrays, and phenocycling at the tissue-level using fresh/frozen tissues
  • Immunofluorescence staining and analysis on our EVOS microscope
anna branco taking images on the EVOS microscope
Anna taking images on the EVOS microscope
human gestational membrane immunohistochemistry H&E


Find our research publications via the US National Library of Medicine at the National Institutes of Health on PubMed.

View publications Publications
the aronoff lab in front of a white board of notes

The Aronoff Lab Team

The Aronoff Lab consists of many individuals with diverse backgrounds in varying fields of science.

Meet the team The Aronoff Lab Team

Scientific Meetings

To help foster collaborative research efforts and to share our findings, we regularly attend several scientific meetings and conferences.

aronoff lab members outside on a rainy day at the March for Science in Nashville in 2017
The Aronoff Lab at the March for Science in Nashville in 2017