Gustavo A. Arrizabalaga, PhD
Assistant Dean for Faculty Affairs & Professional Development
Professor of Pharmacology & Toxicology
Professor of Microbiology & Immunology
- Phone
- (317) 278-6355
- Address
-
MS A418
635 Barnhill Drive
Indianapolis, IN 46202 - PubMed:
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Bio
Dr. Gustavo Arrizabalaga has been studying the cell biology of the pathogenic parasite Toxoplasma gondii for over 20 years. He received his Ph.D. in Biology from MIT under the mentorship of Dr. Ruth Lehmann. His doctoral work focused on developmental biology and translational regulation using Drosophila as a model system. From 1999 to 2004 Dr. Arrizabalaga did a post-doctoral fellowship with Dr. John Boothroyd at Stanford University School of Medicine, where he began focusing on how Toxoplasma gondii exits its host cell. From 2004 to 2012 he was a faculty member at the University of Idaho where he established an independent research group. In 2012, he joined the Departments of Pharmacology and Toxicology and Microbiology and Immunology as an Associate Professor. He was promoted to full professor in 2017. He currently serves as an Assistant Dean for Faculty Affairs and Professional Development
Key Publications
Severo V, Souza R, F Vitorino F, Cunha J, Ávila A, Arrizabalaga G, and Nardelli S. 2022 The missed histone H1 is involved in cell division and ribosome biosynthesis in Toxoplasma gondii" mSphere
Dominicus C, Nofal SD, Broncel M, Katris NJ, Flynn HR, Arrizabalaga G, Botté CY, Brandon Invergo M, Treeck M. 2022 A positive feedback loop mediates crosstalk between calcium, cyclic nucleotide and lipid signalling in Toxoplasma gondii. PLOS Pathogens 2022 Oct 20;18(10):e1010901. doi: 10.1371/journal.ppat.1010901.
Souza, R.O.O, Jacobs, K., Back, PS, Bradley, PJ Arrizabalaga G. 2022 IMC10 and LMF1 mediate membrane contact between the mitochondrion and the inner membrane complex in Toxoplasma gondii. Journal of Cell Sciences Oct 31:jcs.260083. doi: 10.1242/jcs.260083.
Yang C, Blakely WJ, Arrizabalaga G. 2022 The tyrosine phosphatase PRL regulates attachment of Toxoplasma gondii to host cells and is essential for virulence. mSphere 7(3):e0005222
Dave N, Arrizabalaga G. 2022 An EF hand protein in Toxoplasma gondii localizes to the endolysosomal complex and regulates egress. Cells 11(10): 1709
Blakely WJ, Holmes MJ, Arrizabalaga G. 2020. The secreted acid phosphatase domain-containing GRA44 from Toxoplasma gondii is required for C-myc induction in infected cells mSphere. 2020 Feb 19;5(1):e00877-19. doi: 10.1128/mSphere.00877-19.
Jacobs K, Charvat R, Arrizabalaga G. 2019. Identification of Fis1 interactors in Toxoplasma gondii reveals a novel protein required for peripheral distribution of the mitochondrion. mBio. 2020 Feb 11;11(1):e02732-19. doi: 10.1128/mBio.02732-19.
Yang, C., Broncel, M., Dominicus, C., Sampson, E., Blakely, W. J., Treeck, M., Arrizabalaga G., 2019 A plasma membrane localized protein phosphatase in Toxoplasma gondii, PPM5C, regulates attachment to host cells. Sci Rep 9:5924.
Heredero-Bermejo I, Varberg JM, Charvat R, Jacobs K, Garbuz T, Sullivan WJ Jr, Arrizabalaga G., 2018TgDrpC, an atypical dynamin-related protein in Toxoplasma gondii, is associated with vesicular transport factors and parasite division., Molecular microbiology. 2019; 111(1):46-64.
Varberg, J., Coppens, I., Arrizabalaga, G. and Gaji, R.Y., 2018. TgTKL1 is a unique plant like nuclear kinase that plays an essential role in acute toxoplasmosis. mBio 20;9(2).
Panozzo-Zénere E.A., Porta E.O., Arrizabalaga G., Fargnoli L., Khan S.I., Tekwani B.L., and Labadie, G.R., 2017 A minimalistic approach to develop new anti-apicomplexa polyamines analogs, European Journal of Medicinal Chemistry
Varberg, J.M., LaFavers, K.A., 1Sullivan, W.J., 1Arrizabalaga, G., 2017 Characterization of Plasmodium Atg3-Atg8 interaction inhibitors identifies novel alternative mechanisms of action in Toxoplasma gondii, Antimicrob Agents Chemother., PMID:29158278 1Senior authors contributed equally
Garbuz, T. and Arrizabalaga, G., 2017 Lack of mitochondrial MutS homolog 1 in Toxoplasma gondii disrupts maintenance and fidelity of mitochondrial DNA and reveals metabolic plasticity, Plos One, PMID:29141004
Roiko, M.S., LaFavers, K., Arrizabalaga, G., 2017 Toxoplasma gondii-positive human sera recognize intracellular tachyzoites and bradyzoites with diverse patterns of immunoreactivity, Int J. for Parasitology.
LaFavers, K.A, Márquez-Nogueras, K.M., Coppens, I., Moreno, SNJ, Arrizabalaga, G., 2017 A novel dense granule protein, GRA41, regulates timing of egress and calcium sensitivity in Toxoplasma gondii. Cell Microb, PMID: 28430089
Colinot, D.L., Garbuz, T., Bosland, M., Rice, S., Wang, L., Sullivan, W.J., 1Jerde, T. 1Arrizabalaga, G., 2017 Toxoplasma gondii: a novel inducer of chronic prostatic inflammation and proliferative inflammatory microglandular hyperplasia in a mouse model of prostatic inflammation. Prostate, PMID: 28497488. 1 Senior authors contributed equally
Padgett, L., 1Sullivan, W.J., 1Arrizabalaga, G., 2016, Targeting of tail-anchored membrane proteins to subcellular organelles in Toxoplasma gondii. Traffic. 2017 Mar;18(3):149-158. PMID:27991712 1 Senior authors contributed equally
Charvat, R. and Arrizabalaga, G., 2016. Oxidative stress generated during monensin treatment contributes to altered Toxoplasma gondii mitochondrial function. Nature Scientific Reports, Mar 15;6. PMID: 26976749
Gaji, R., Johnson, D., Wang, M., Hudmon, A., and Arrizabalaga, G., 2015. Phosphorylation of a Myosin motor by TgCDPK3 facilitates rapid initiation of motility during Toxoplasma gondii egress. PLoS Pathog. 1(11):e1005268. PMID: 26544049
Benmerzouga, I., Checkley, L., Ferdig, M., Arrizabalaga, G., Wek, R., and Sullivan, W., 2015. Guanabenz repurposed as an anti-parasitic with activity against acute and latent toxoplasmosis, Antimicrob Agents Chemother, 59(11):6939-45. PMID: 26303803
Treeck, M., Sanders, J., Gaji, R., LaFavers, K., Child, M., Arrizabalaga, G., Elias, J., Boothroyd, J., 2014. A novel role of Calcium-dependent Kinase 3 in regulating metabolism in Toxoplasma gondii in addition to ionophore induced egress. PLoS Pathogen, 10(6):e1004197. PMID: 24945436
Gaji, R., Checkley, L., Reese, M., Ferdig, M.T., and Arrizabalaga, G., 2014. Expression of the essential kinase PfCDPK1 from Plasmodium falciparum in Toxoplasma gondii facilitates the discovery of novel antimalarial drugs. Antimicrob Agents Chemother, 58(5):2598-607. PMID: 24550330
Garrison, E., Treeck, M., Ehret, M., Garbuz, T., Oswald, B.P., Settles, M., Boothroyd, J., Arrizabalaga, G., 2012. A forward genetic screen reveals calcium-dependent kinase 3 is critical for calcium-induced egress in Toxoplasma. Plos Pathogen, 8(11). PMDI: 23209419
Lavine, M.D. and Arrizabalaga, G., 2012, Analysis of Monensin Sensitivity in Toxoplasma gondii reveals autophagy as a mechanism for drug induced death. Plos One, 7(7):e42107. PMID: 22848721
Francia, M.E., Wicher S., Pace D.A., Sullivan, J., Moreno, S.N.J., and Arrizabalaga, G., 2011. A Toxoplasma protein with homology to intracellular type Sodium Hydrogen Exchangers is required for osmotolerance and protein processing. Experimental Cell Research. 317(10):1384-96. PMID: 21501607
Lavine, M.D. and Arrizabalaga, G., 2011. The antibiotic monensin causes cell cycle disruption of Toxoplasma gondii, mediated through the DNA repair enzyme TgMSH-1. Antimicrob Agents Chemother, 55(2): 745-55. PMID: 21098240
Garrison, E. and Arrizabalaga, G., 2009. Disruption of a mitochondrial homolog of a MutS DNA Repair Enzyme confers drug resistance in the pathogenic parasite Toxoplasma gondii. Molecular Microbiology, 72(2):425-41. PMID 19291232
Arrizabalaga, G., Ruiz, F., Moreno, S. and Boothroyd J.C., 2004. Ionophore-resistant mutant of Toxoplasma gondii reveals involvement of a sodium/hydrogen exchanger in calcium regulation. Journal of Cell Biology: 165(5):653-62,. PMID: 15173192
| Year | Degree | Institution |
|---|---|---|
| 2004 | Fellowship | Stanford University School of Medicine |
| 1999 | PhD | Massachusetts Institute of Technology |
| 1992 | BS | Haverford College |
My research focuses on the cell signaling events that drive the propagation of the parasiteToxoplasma gondii. This remarkable parasite infects any warm blooded animal, can invade any nulceated cell, is found everywhere in the world, and infects a third of the world population. Toxoplasma can cause birth defects, and opportunistic disease in HIV/AIDS, cancer and organ transplant patients. A great part of the pathogenesis associated with toxoplasmosis is due to the repeating cycles of cell invasion, replication and egress that drive its propagation through an infected individual. Our lab is interested in the signaling pathways that regulate various aspects of this lytic cycle. Given that events such as invasion and egress are essential for parasite survival and that Toxoplasma uses some unique signaling molecules our studies aim at discovering novel targets for the development of much needed anti-parasitic drugs.
Desc: Trustee Teaching Award
Scope: University
Date: 2022-09-01
Desc: Trustee Teaching Award
Scope: University
Date: 2017-05-01