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Allen Lab

The laboratory led by Matthew R. Allen, PhD studies the tissue-level mechanisms responsible for musculoskeletal integrity in health and disease by utilizing numerous in vivo model systems that help investigators understand how disease and pharmaceutical intervention influence bone structure, cellular activity, tissue-level properties (such as mineralization, microdamage, collagen, hydration), and biomechanical properties.

The laboratory studies a range of diseases/conditions, including osteoporosis, chronic kidney disease, and disuse using techniques that include imaging (CT, DXA, X-ray), histology (static and dynamic histomorphometry, microdamage), and mechanical testing (bending, compression, fatigue loading).

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Active Research

  • Enhancing bone strength using combination drug therapy

    NIH R01 – AR 062002

    Matthew Allen

  • Treating bone deterioration associated with chronic kidney disease
    VA Merit grant – BX003025

    Matthew R. Allen

  • Pathogenesis of compromised bone quality and mechanics in chronic kidney disease
    NIH R01 DK110871

    Multi PI – Matthew R. Allen, Sharon Moe, Tom Nickolas

  • Assessing and modifying bone quality in chronic kidney disease
    NIH – F30 DK100093

    Chris Newman; Mentors: Matthew R. Allen & Sharon Moe

  • The role of bone trait covariation in vertebral fracture resistance
    NIH R01AR064244

    Todd Bredbenner

  • Assessing and improving bone quality in chronic kidney disease
    NIH – F32 DK108554

    Erin McNerny; Mentors: Matthew R. Allen & Sharon Moe

  • Mechanical size effects and bone failure
    NSF – EAGER

    Co-PI – Matthew R. Allen and Thomas Siegmund

Research Faculty

5035-Allen, Matthew

Matthew R. Allen, PhD

Assistant Dean for Faculty Affairs and Professional Development

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