Faculty Research Labs

Faculty Labs

Successful biomedical research demands collaboration among scientists with varying specialties. Faculty throughout IU School of Medicine's 26 academic departments work together to advance knowledge and treatment for patients in the world's most critical areas of medicine.

Adams Lab

In the research laboratory led by Zachary Adams, PhD, investigators are focused on improving access to high-quality clinical services for children, teens and families impacted by mental health problems and substance use—through research, clinical care and education.

Principal Investigator

Zachary W. Adams, PhD

Department

Psychiatry

Allen Lab

The Allen Laboratory (Indianapolis) is studying the tissue-level mechanisms responsible for musculoskeletal integrity in health and disease by utilizing numerous in vivo model systems that help investigators understand how disease and pharmaceutical intervention influence bone structure, cellular activity, tissue-level properties, and biomechanical properties.

Principal Investigator

Matthew R. Allen, PhD

Alpini Lab

Alpini Lab The Alpini Lab, led by Gianfranco Alpini, PhD, evaluates the regulation of cholangiocyte proliferation/damage during the progression of cholangiopathies, the chronic diseases that target intrahepatic cholangiocytes. Proliferating cholangiocytes display a neuroendocrine phenotype and secrete and respond to a number of hormones, neuropeptides and neurotransmitters in autocrine and paracrine signaling mechanisms.

Principal Investigator

Gianfranco Alpini, PhD

Department

Gastroenterology

Accepting Students

Alves Lab

Research in the Alves Lab (Indianapolis) focuses on the interdisciplinary development of translational technologies, treatments and techniques that can be used to have a positive impact on people’s lives. A chemical and bimolecular engineer, Nathan Alves, PhD, encourages researchers to apply engineering principles and designs to create translational technologies for clinical implementation.

Principal Investigator

Nathan J. Alves, PhD, MS

Apostolova Lab

Dr. Apostolova’s research focuses on the early symptomatic and presymptomatic stages of Alzheimer’s disease and on the development and validation of sensitive imaging and genetic biomarkers for Alzheimer’s disease and other dementing disorders. (Indianapolis)

Principal Investigator

Liana G. Apostolova, MD, MSC, FAAN

Department

Neurology

Arrizabalaga Lab

Current projects in the Arrizabalaga Lab (Indianapolis) involve the characterization of kinases, phosphatases and other signaling proteins involved in the process by which the parasite exits its host cell and the characterization of autophagy-related proteins in mitochondrial dynamics and parasite death.

Atwood Lab

The Atwood Laboratory (Indianapolis) team is interested in how drugs of abuse, diet, stress and pain influence the behaviors of humans. The focus of the lab’s work is on the molecular mechanisms and brain circuits that are specifically impacted by these substances and experiences.

Principal Investigator

Brady K. Atwood, PhD

Department

Psychiatry

Bellido Lab

The Bellido Laboratory (Indianapolis) investigates the mechanisms of signal transduction among and within bone cells, with particular emphasis on the biology of osteocytes.

Principal Investigator

Teresita Bellido, PhD

Bidwell Lab

The Bidwell Lab (Indianapolis) is exploring improvement of therapies for restoring bone lost to osteoporosis or other diseases.

Principal Investigator

Joseph P. Bidwell, PhD

Block Lab

Research in the Block Laboratory (Indianapolis) is centered on identifying how microglia, the resident innate immune cells in the brain, can become a chronic source of cytokines and reactive oxygen species that drive progressive neuron damage.

Principal Investigator

Michelle L. Block, PhD

Bonewald Lab

The Bonewald Laboratory (Indianapolis) focuses on the biology and function of the osteocyte.

Principal Investigator

Lynda Bonewald, PhD

Boothman Lab

The Boothman Lab (Indianapolis) is working to understand and exploit cell stress responses in cancer versus normal cells.

Broxmeyer Lab

The Broxmeyer Lab (Indianapolis) focuses on mechanisms regulating proliferation, survival, self-renewal, metabolism, differentiation and homing/mobilization of hematopoietic, embryonic and induced pluripotent stem cells at cellular, intracellular and animal levels.

Principal Investigator

Hal E. Broxmeyer, PhD

Brustovetsky Lab

The Brustovetsky laboratory (Indianapolis) is working to determine the mechanisms of calcium deregulation, mitochondrial dysfunction, and neuronal death in aging and age-related neurodegenerations such as Huntington’s disease.

Brutkiewicz Lab

The Brutkiewicz Lab (Indianapolis) studies immune evasion by microbial pathogens and tumors as well as the regulation of antigen presentation by various signal transduction pathways in both innate and adaptive immune responses.

Burr Lab

The primary area of research for the Burr Lab (Indianapolis) is to evaluate the effects of pharmacologic agents used to treat osteoporosis on properties associated with quality of the bone matrix.

Principal Investigator

David Burr, MD

Chen Lab

The Chen Lab (Indianapolis), led by Peng-Sheng Chen, MD, is part of the Krannert Institute of Cardiology, Division of Cardiology, Department of Medicine at IU School of Medicine. The primary interest of the laboratory is to advance science related to cardiac arrhythmias. Members of the laboratory also collaborate widely within the institute and provide basic science support to various basic science and clinical...

Principal Investigator

Peng-Sheng Chen, MD

Department

Medicine

Clauss Lab

The research lab (Indianapolis) of Matthias Clauss, PhD, is focused on vascular function and repair are involved in many diseases, in particular in those of the cardiopulmonary system.

Clinkenbeard Lab

The Clinkenbeard Lab (Indianapolis) is exploring the molecular mechanism driving bone loss in chronic kidney disease: mineral and bone disorder (CKD-MBD).

Conway Lab

The Conway Lab (Indianapolis) is located in the Herman B Wells Center for Pediatric Research and focuses on the examination and manipulation of the molecular regulatory mechanisms that govern cardiopulmonary development and disease.

Principal Investigator

Simon Conway, PhD

Department

Pediatrics

Cornetta Lab

The Cornetta Lab (Indianapolis) is using viral-based gene transfer as a means of introducing genetic sequences to correct mutations and ameliorate disease.

Corson Lab

The Corson Lab (Indianapolis) applies chemical biology to issues relating to eye disease, including age-related macular degeneration and other neovascular eye diseases. The research team is also exploring the biology of and potential therapies for pediatric ocular cancer retinoblastoma.

Principal Investigator

Timothy W. Corson, PhD

Department

Ophthalmology

Dent Lab

The Dent Laboratory (Indianapolis) is focused on the regulation of the immune response by CD4 T helper and regulatory T cells.

Principal Investigator

Alexander Dent, PhD

Derbigny Lab

The Derbigny Lab (Indianapolis) is working to characterize the cellular immune responses of epithelial cells lining the lumen of the oviduct and describing their contributions to the overall immune response to Chlamydia infections.

Principal Investigator

Wilbert A. Derbigny, PhD

Dong Lab

Dr. Charlie Dong’s laboratory (Indianapolis) focuses on the pathogenesis of aging, cancer, diabetes, obesity, and fatty liver disease.

Principal Investigator

X C. Dong, PhD

Dynlacht Lab

The Dynlacht Lab (Indianapolis) studies the effects of physical and chemical agents that modulate the response of cancer cells and normal tissue to the radiation response, particularly hyperthermia and various chemotherapeutic agents.

Principal Investigator

Joseph R. Dynlacht, PhD

Edenberg Lab

The Edenberg Lab (Indianapolis) focuses on the genetics and genomics of alcoholism, bipolar disorder and other complex diseases.

Elmendorf Lab

The research lab of Jeffrey Elmendorf (Indianapolis) dissects mechanisms of insulin action that regulate glucose uptake by fat and muscle cells, and defines defects contributing to insulin resistance associated with obesity and type 2 diabetes.

Fehrenbacher Lab

The Jill C. Fehrenbacher, PhD, laboratory (Indianapolis) is focused on how diseases and drugs can modulate the function of peripheral sensory neurons to underlie clinical neuronal dysfunction.

Field Lab

The Field Lab (Indianapolis) focuses on regenerative growth of the heart. The lab works to develop strategies to monitor the intrinsic rates of cardiomyocyte cell cycle renewal in normal and injured adult hearts, as well as strategies to induce regenerative growth following myocardial injury.

Principal Investigator

Loren Field, PhD

Department

Pediatrics

Francis Lab

The Francis lab, led by Heather Francis, PhD, focuses on understanding and identifying target therapies for chronic and often fatal liver diseases. Cholangiopathies are diseases that target cholangiocytes and include diseases like Primary Biliary Cholangitis (PBC), Primary Sclerosing Cholangitis (PSC) and Cholangiocarcinoma (CCA).

Principal Investigator

Heather Francis, PhD

Department

Gilk Lab

The Gilk Lab (Indianapolis) uses a combination of cell biology, biochemistry and molecular biology to address the role of cholesterol in Coxiella-host cell interactions.

Principal Investigator

Stacey D. Gilk, PhD

Graham Laboratory

The Graham Laboratory (Indianapolis) is studying the genetics of metabolic function and disease through the manipulation of genetic model systems, particularly the mouse and the fruit fly, Drosophila melanogaster.

Guo Lab

The Guo Laboratory (Indianapolis) focuses on the viral pathogenesis of hepatitis B virus (HBV) and antiviral discovery.

Principal Investigator

Haitao Guo, PhD

Hashino Lab

The Hashino Lab (Indianapolis) leverages expertise in CRISPR/Cas9 genome-editing technology to generate inner ear/brain organoids harboring disease-associated mutations and also various reporter stem cell lines for prompt identification of specific cell types.

Principal Investigator

Eri Hashino, PhD

Department

Otolaryngology

Hawkins Lab

Investigators in the Hawkins laboratory (Indianapolis) use next generation sequencing, mouse models, 3D bioprinting, and human samples to study benign and malignant diseases of the female reproductive tract, including endometriosis, endometriosis-associated ovarian cancer, endometrial dysfunction, and endometrial cancer.

Herbert Lab

The Herbert Lab (Indianapolis) studies the roles of telomeres and telomerase in aging and cancer.

Herzog Lab

The Herzog Lab (Indianapolis) focuses on developing gene therapies that result in a lasting cure of the inherited disorder hemophilia.

Principal Investigator

Roland Herzog, PhD

Department

Pediatrics

Hulvershorn Lab

The research lab of Leslie Hulvershorn, MD at Indiana University School of Medicine (Indianapolis) is focused on understanding more about risky decision-making in youth, including how the brain processes risky decisions and how it influences health like acquiring infectious diseases, suicidal behavior and using drugs of abuse.

Principal Investigator

Leslie A. Hulvershorn, MD

Department

Psychiatry

Hurley Lab

The Hurley Lab (Indianapolis) is exploring, at the molecular level, the processes involved in the recognition and binding of molecules that are directed to the active sites of enzymes. Recent work has challenged the team to understand the functional distinction between active site directed inhibitors as well as activators.

Ivan Lab

The Ivan Lab (Indianapolis) is studying the metabolic branches of the hypoxic response and how they can be exploited for synergistic anticancer combinations in solid tumors (with emphasis on brain cancer).

Principal Investigator

Mircea Ivan, MD, PhD

Department

Medicine

Jin Lab

Research in the Jin Lab (Indianapolis) focuses on the organization and plasticity of neural circuits in the cerebral cortex, and the mechanisms of epileptogenesis following traumatic brain injury.

Principal Investigator

Xiaoming Jin, PhD

John Lab

The lab of Chandy John, MD (Indianapolis) focus of research is on malaria, one of the leading causes of death and long-term morbidity in children under five years of age worldwide.

Principal Investigator

Chandy C. John, MD, MS

Department

Pediatrics

Johnson Lab

The Johnson Lab (Indianapolis) at IU School of Medicine is investigating the mechanisms of centrally regulated anxiety and panic associated behavior that coincides with cardiorespiratory and thermoregulatory activity.

Principal Investigator

Philip L. Johnson, PhD

Jones Lab

The Jones Laboratory (Indianapolis) focuses on neural injury and repair, gonadal steroids as neurotherapeutics, neuroimmunology, and ALS.

Principal Investigator

Kathryn J. Jones, PhD

Kacena Lab

The Kacena Lab (Indianapolis) is exploring the interaction of the bone and hematopoietic systems to improve the treatment of metabolic bone disease, hematopoietic disorders and fracture healing.

Principal Investigator

Melissa A. Kacena, PhD

Kaplan Lab

The Kaplan Laboratory (Indianapolis) focuses on transcription factors that are involved in the development of T helper cell subsets and how those cells contribute to inflammation in allergic and autoimmune diseases.

Principal Investigator

Mark Kaplan, PhD

Kareken Lab

The Kareken Lab (Indianapolis) focuses on understanding the brain and genetic vulnerabilities that may predispose individuals to alcoholism.

Principal Investigator

David A. Kareken, PhD

Department

Neurology

Katzenellenbogen Lab

The Katzenellenbogen Lab (Indianapolis) is focused on the host-pathogen interactions that activate oncogenic pathways and dysregulate typical cellular processes to permit cancer development and progression of HPV-associated cancers.

Kelley Lab

The Kelley Lab (Indianapolis) focuses on translational research in DNA damage and repair as well as redox signaling pathways in tumor and normal cells, with extensive expertise on the apurinic/apyrimidinic endonuclease 1/ Redox effector factor-1 (APE1/Ref-1) enzyme.

Principal Investigator

Mark R. Kelley, MS, PhD

Department

Pediatrics

Kim Lab

Research in the Kim Lab (Indianapolis) focuses on therapeutic strategies for Alzheimer’s disease. This research team is studying brain lipid-regulating proteins, such as apolipoprotein E (ApoE), low density lipoprotein receptor (LDLR), and ATP-binding cassette transporter A1 (ABCA1).

Principal Investigator

Jungsu Kim, PhD

Kline Lab

The Kline Lab (Indianapolis) focuses on venous thromboembolism, and his lab conducts clinical and applied laboratory research intended to improve the therapeutic index of all steps of venous thromboembolism diagnosis and treatment.

Principal Investigator

Jeffrey A. Kline, MD

Koehler Lab

The Koehler Lab (Indianapolis) generates organoids within a 3D culture system in pursuit of establishing regenerative therapies for rebuilding auditory nerves for improved hearing as well as craniofacial tissues for improved skin grafting techniques.

Principal Investigator

Karl R. Koehler, PhD

Department

Otolaryngology

Kota Lab

The Kota lab (Indianapolis) is focused on understanding the pathophysiological role of microRNAs (miRNAs) in disease mechanisms associated with advanced forms of human cancers, such as pancreatic and liver cancers, and exploring their therapeutic and biomarker potential.

Principal Investigator

Janaiah Kota

Landreth Lab

The Landreth Lab (Indianapolis) focuses on the biological basis of Alzheimer’s disease (AD)—specifically, how genetic risks factors influence disease pathogenesis.

Principal Investigator

Gary Landreth, PhD,

Lasagna-Reeves Lab

The Lasagna-Reeves Lab (Indianapolis) is studying the role of protein tau in neurodegenerative diseases.

Lautenschlaeger Lab

The Lautenschlaeger Lab team (Indianapolis) is working to measure and predict response to radiation therapy in solid tumors with the goal to develop biomarker-guided personalized radiation prescriptions and follow-up care.

Principal Investigator

Tim Lautenschlaeger, MD

Liangpunsakul Lab

The Liangpunsakul Lab, led by Suthat Liangpunsakul, MD, focuses on the identification of non-invasive biomarkers to screen for excessive alcohol use and the molecular mechanism, risk factors, and treatment for alcohol-associated liver disease (ALD). This research spans from basic molecular mechanism in mouse models, translational research studies using human biosamples to explore the role of immune cells in the pathogenesis...

Principal Investigator

Liangpunsakul

Department

Gastroenterology

Accepting Students

Liu Lab

The research laboratory (Indianapolis) led by Yunlong Liu, PhD, develops innovative computational and high-throughput genomics approaches in studying gene regulation, with the focus on splicing regulation.

Principal Investigator

Yunlong Liu, PhD

Lobashevsky Lab

The Lobashevsky Lab (Indianapolis) focuses on Human Leukocyte Antigen (HLA)  studies and performs tests aimed at selecting potential organ donors. The laboratory team also monitors the functional status of patients’ immune cells and tests for paternity.

Principal Investigator

Andrew Lobashevsky, MD, PhD

Department

Medicine

Lu Lab

The research laboratory (Indianapolis) of Dr. Tao Lu focuses on addressing how NF-κB is regulated and how this regulation contributes to tumorigenesis.

Principal Investigator

Tao Lu, PhD

Lu Lab

The Lu Lab (Indianapolis) studies cancer biology, identifying novel drug targets and therapies, and developing new cancer drugs using innovative nanoscale biomaterials.

Principal Investigator

Xiongbin Lu, PhD

McNulty Lab

The basic science research in the lab of Margaret McNulty, PhD focuses on bone and joint pathology. The McNulty lab (Indianapolis) uses both advanced imaging (e.g. micro-computed tomography) and histological techniques to evaluate changes in bones and joints secondary to various diseases and treatments.

Principal Investigator

Margaret McNulty, PhD

Mendonca Lab

Research in the Mendonca Lab (Indianapolis) is focused on gaining a better understanding of radiation’s ability to both heal and harm.

Principal Investigator

Marc S. Mendonca, PhD

Meng Lab

The research program of Fanyin Meng, PhD focuses on the pathogenesis of non-coding RNAs and extracellular vesicles regulated human cholestatic and alcoholic liver injuries, hepatocellular carcinoma and cholangiocarcinoma and identifying new therapeutic avenues to treat these diseases.

Principal Investigator

Meng

Department

Gastroenterology

Accepting Students

Mosley Lab

The Mosley Lab (Indianapolis) is focused on uncovering novel mechanisms involved in the control of RNA Polymerase II transcription elongation and termination. This work is foundational to understanding how transcription is controlled in normal cells and how these pathways are defective in a wide-array of human diseases including cancers, diabetes and neuropathologies.

Motea Lab

The Motea Lab (Indianapolis) studies the molecular basis of carcinogenesis and genomic instability induced by endogenous and exogenous genotoxic agents, translesion DNA synthesis, persistent R-loops (RNA:DNA hybrid structures), and aberrant DNA damage response and repair pathways.

Nelson Lab

The Nelson Lab, led by Rick Nelson, MD, PhD, is interested in elucidating the mechanisms that underlie hair cell degeneration as it relates to deafness and balance disorders. (Indianapolis)

Principal Investigator

Rick F. Nelson, MD, PhD

Department

Otolaryngology

Nelson Lab

The Nelson Lab (Indianapolis) is studying chlamydial pathogenesis, microbiome pathogen interactions and pathogen discovery.

Principal Investigator

David E. Nelson, PhD

O’Connell Lab

The O’Connell Lab (Indianapolis) focuses on applying integrated metabolomics analyses to develop new precision diagnostics and determine the metabolic drivers of cancer-associated cachexia and other wasting conditions.

Principal Investigator

Thomas M. O

Department

Otolaryngology

Oberlin Lab

Dr. Oberlin’s lab (Indianapolis) identifies behavioral risk variables, brain regions, and systems governing impulsive addiction choices and the impact of cues on those choices.

Principal Investigator

Brandon Oberlin, PhD

Department

Psychiatry

Organ Lab

The Organ Lab (Indianapolis) at IU School of Medicine studies the relationship between bone and muscle mechanics at the whole-organ level, and explores how tissue-level mechanisms influence whole-organ function.

Principal Investigator

Jason Organ, PhD

Paczesny Lab

The Paczesny Lab at IU School of Medicine (Indianapolis) is working to better understand the role of cytokines and cellular effectors in the biology of GVHD/GVL by discovering and investigating biomarkers in the blood and tissues of patients following allogeneic HSCT.

Principal Investigator

Sophie Paczesny, MD, PhD

Pelus Lab

The Pelus Lab (Indianapolis) focuses on understanding the regulation of survival proliferation and differentiation of normal adult blood and mesenchymal stem cells, how they respond to stress, and how this knowledge can be leveraged for therapeutic application in the areas of bone marrow transplantation, gene therapy and protection and mitigation of radiation injury.

Principal Investigator

Louis M. Pelus, PhD

Plotkin Lab

The Plotkin Lab (Indianapolis) focuses on the role of connexins in the transduction of signals induced by hormonal, pharmacotherapeutic and mechanical stimuli in osteoblasts and osteocytes.

Principal Investigator

Lillian Plotkin, PhD

Pollok Lab

The Pollok Lab (Indianapolis) focuses on the development of new combination therapies for solid tumors with emphasis on investigations that evaluate the therapeutic effect of blocking DNA damage and repair pathways in the context of front-line therapies.

Principal Investigator

Karen E. Pollok, PhD

Department

Pediatrics

Quilliam Lab

The focus of the Quilliam Laboratory (Indianapolis) is on cancer-cellular signaling. The lab is interested in delineating signal transduction pathways induced by growth-stimulatory factors, and in determining the mechanisms by which these pathways are activated during the course of malignant transformation.

Roach Lab

The Roach Lab (Indianapolis) is primarily focused on the metabolism of glycogen, its regulation, and the clinical consequences of its defects, as exhibited in glycogen storage diseases (glycogenoses).

Robinson Lab

The Robinson Lab (Indianapolis) studies the complex methods in which enteric viruses traverse the intestinal environment to initiate infection. The laboratory specifically identifies intestinal factors that influence viral replication.

Robling Lab

The Robling Laboratory (Indianapolis) is investigating the molecular mechanisms by which bone tissue senses mechanical loading, by studying how several signal transduction pathways affect bone accumulation and how cellular activity is altered by mechanical stimulation.

Principal Investigator

Alexander Robling, PhD

Safa Lab

The Safa Lab (Indianapolis) is particularly interested in multi-targeted therapy of brain cancer, breast cancer and pancreatic tumors through modulation of the death receptor signaling pathway in cancer cells.

Principal Investigator

Ahmad R. Safa, PhD

Sankar Lab

The Sankar Laboratory (Indianapolis) at IU School of Medicine is investigating the mechanisms by which members of the Calcium/calmodulin-dependent protein kinase (CaMK) signaling cascade, CaMKK2 (along with its downstream kinases AMPK, CaMKI and CaMKIV) regulate the fate and function of bone marrow-derived mesenchymal stem cells, osteoblasts and osteoclasts.

Principal Investigator

Uma Sankar, PhD

Spaeth Lab

The Spaeth Lab (Indianapolis) focuses on the pathogenesis of diabetes mellitus and islet cell function. The lab investigates how transcriptional coregulators modulate activities of islet enriched transcription factors that are critical for pancreas formation, islet cell development and function.

Principal Investigator

Jason Spaeth, PhD

Department

Pediatrics

Spinola Lab

The Spinola Laboratory (Indianapolis) focuses on the bacterium Haemophilus ducreyi, which causes cutaneous ulcers in children in the tropics and the genital ulcer disease chancroid, which facilitates the transmission of HIV-1.

Principal Investigator

Stanley M. Spinola, MD

Srour Lab

The Srour Lab (Indianapolis) is studying the characterization and biology of human and murine hematopoietic stem cells (HSC) and interactions between cellular elements of the hematopoietic niche and HSC.

Principal Investigator

Edward F. Srour, PhD

Department

Medicine

Sullivan Lab

The Sullivan Laboratory (Indianapolis) studies cellular signaling and the regulation of gene expression in a protozoan parasites Plasmodium (malaria) and Toxoplasma (toxoplasmosis).

Principal Investigator

William J. Sullivan, PhD

Takagi Lab

The Takagi Lab (Indianapolis) is interested in functionally and structurally deciphering molecular machines of gene regulation, and is particularly interested in the Mediator complex, a crucial component of transcription regulation in all eukaryotes.

Tepper Lab

The research laboratory of Robert Tepper, MD, PhD focuses on lung structure and function as it relates to airway hyper-reactivity, as well as lung growth and development.

Principal Investigator

Robert S. Tepper, MD, PhD

Department

Pediatrics

Truitt Lab

The Truitt Lab (Indianapolis) is focused on determining how social interactions can be used to overcome anxiety. This lab team hopes to contribute to elucidating the neural mechanism by which psychotherapy helps patients overcome anxiety.

Principal Investigator

William A. Truitt, PhD

Tune Lab

The research lab of Johnathan D. Tune, PhD, focuses on the regulation of coronary blood flow, contractile function and metabolism in health and disease. (Indianapolis)

Turner Lab

The research laboratory of Matthew Turner, MD, PhD, focuses on the interaction between skin injury, inflammation and wound healing.

Principal Investigator

Matthew J. Turner, MD PhD

Department

Dermatology

Vilseck Lab

The Vilseck Laboratory, led by Jonah Vilseck, PhD, is focused on the development and application of state-of-the-art computer simulations to provide atomistic insights into the mechanisms and thermodynamics of protein–ligand and protein–protein binding.

Principal Investigator

Jonah Vilseck

Accepting Students

Wells Lab

The Wells Lab (Indianapolis) investigates early changes in cell behavior that contribute to the initiation of breast and brain cancer.

White Lab

The laboratory of Kenneth White, PhD, (Indianapolis) is studying the molecular genetics of metabolic bone diseases involving the osteocyte-derived hormone fibroblast growth factor-23 (FGF23). Mutations in FGF23 are responsible for the human phosphate wasting disorder autosomal dominant hypophosphatemic rickets (ADHR) and the converse disorder hyperphosphatemic familial tumoral calcinosis (hfTC). Studies in animal models and in cells are underway to elicit the...

Principal Investigator

Kenneth White, PhD

White Lab

Under the direction of Fletcher A. White, PhD, research in the White Lab (Indianapolis) focuses on the mechanistic development and chronicity of pain due to traumatic brain injury (TBI), peripheral nerve injury, polytrauma, chemotherapeutics and disease.

Principal Investigator

Fletcher A. White, PhD

Department

Anesthesia

Williams Lab

The Williams’ lab, led by James C. Williams, Jr., PhD, is learning why kidney stones form and what the bioeffects are of kidney stone removal when using different treatment modalities. (Indianapolis)

Principal Investigator

James C. Williams, PhD

Wu Lab

The Wu Lab (Indianapolis) studies a wide range of radiology and imaging topics, with a particular focus on diffusion physics in biologic system using diffusion MRI.

Principal Investigator

Yu-Chien Wu, MD, PhD

Xu Lab

The Xu Lab (Indianapolis) is studying the mechanisms underlying traumatic spinal cord injury (SCI) and brain injury (TBI) and to develop novel repair strategies to promote neural reorganization and functional recovery in experimental models of these injuries.

Principal Investigator

Xiao-Ming Xu, PhD

Xu Lab

The Xu Lab (Indianapolis) focuses on researching gynecologic oncology, especially the development and progression of gynecologic cancers at the molecular level.

Principal Investigator

Yan Xu, PhD

Yamamoto Lab

Research from the Yamamoto lab (Indianapolis) over the last 27 years has focused on how drugs of abuse affect the neurochemistry of brain.

Principal Investigator

Bryan K. Yamamoto, PhD

Yang Lab

The Yang Lab (Indianapolis) focuses on heart development. Approaches within the lab include the use of human embryonic stem (ES) cells, human induced pluripotent stem (iPS) cells, tissue engineering and mouse genetic models.

Principal Investigator

Lei Yang

Department

Pediatrics

Yang Lab

The Yang Lab (Indianapolis) studies bacterial pathogenesis—how bacterial pathogens colonize the host, evade host immune response and cause diseases—in order to develop new diagnostic tools and vaccine to detect and prevent bacterial infections.

Principal Investigator

X. Frank Yang, PhD

Yang Lab

Research in the Yang Lab, led by Zhihong (Joe) Yang, PhD is focused on the non-coding RNA’s roles in chronic liver disease, mainly in alcohol-associated liver disease (ALD). Dr. Yang’s current project, which is funded by NIAAA, is to explore the role of H19 and methionine metabolism in ALD.

Principal Investigator

Department

Gastroenterology

Accepting Students

Zhang Lab

The major research interest of the Zhang Lab (Indianapolis) is on tumorigenesis, drug discovery and cancer treatment resistance.

Principal Investigator

Jian-Ting Zhang, PhD

Zhang Lab

The Zhang Lab (Indianapolis) is studying protein regulators and noncoding RNAs in the DNA damage signaling pathway and human cancer, especially as they relate to genome stability, tumor initiation and progression.

Principal Investigator

Xinna Zhang, PhD

Zhang Lab

Led by Jie Zhang, PhD, the Zhang Lab (Indianapolis) focuses on the development and application of translational bioinformatics methods to identify disease genes, pathways and biomarkers in the areas of cancer, neurological disease, and other disorders.

Principal Investigator

Jie Zhang, PhD

Zhao Lab

The Zhao Lab (Indianapolis) focuses on the molecular mechanisms of auditory perception and deafness.

Principal Investigator

Bo Zhao, PhD

Department

Otolaryngology

Zhou Lab

The Zhou Lab (Indianapolis) studies the development and function of effector T helper (Th) cells and regulatory T (Treg) cells and how they impact immune mediated inflammatory diseases.

Principal Investigator

Baohua Zhou, PhD

Department

Pediatrics