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Neuropathology Core

The primary goal of the IADRC Neuropathology Core within the Indiana Alzheimer’s Disease Research Center is to diagnose dementing illnesses and gain novel insights into the mechanisms underlying Alzheimer’s disease and related neurodegenerative dementias. Supported by the Dementia Laboratory developed within the Department of Pathology and Laboratory Medicine, the Neuropathology Core impacts the field of neurodegenerative dementias by characterizing neuropathologically, post-mortem, the central nervous system of individuals longitudinally studied intra vitam. Advanced diagnostic and research methodologies are used to characterize neuropathologic phenotypes along with the identification of structural changes of proteins and genetic factors

The IADRC Neuropathology Core carries out state-of-the-art neuropathological examinations of brain, spinal cord and other tissue samples obtained from individuals affected by neurodegenerative dementia and/or related neurodegenerative diseases. This core supports a large number of national and international scientists with frozen and fixed samples from the tissue repository.

The IADRC Neuropathology Core interacts with the IADRC Clinical Core, Neuroimaging Core and Genetics and Biomarkers Core to study research participants applying concepts of precision medicine. This multidisciplinary approach helps to provide a definitive diagnosis of dementing disorders.  


  • To support research projects related to etiology, pathogenesis, and evolution of dementia
  • To participate in regularly scheduled clinicopathologic conferences to educate clinicians, residents, fellows, medical students and other interested individuals
  • To participate in lectures, seminars, continuing education programs, and symposia to communicate new diagnostic and research developments in neurodegeneration