The Bhatwadekar Lab studies how early changes in the retinal cellular network leads to the diabetic retinopathy. Pioneering studies in the lab demonstrated that circadian rhythms similar to sleep-wake cycle are abnormal in the retina in case of diabetic retinopathy. Future studies are aimed at restoring abnormal circadian rhythm to correct the vision problems. Additional focuses include pharmacy outcome research.
The Corson Lab studies: neovascularization; abnormal blood vessel growth in the eye, which is a key feature of diseases like age-related macular degeneration; diabetic retinopathy; retinopathy of prematurity; and cancers of the eye. The lab is interested in finding new pathways that regulate blood vessel growth and targeting these with new chemicals that could be the basis for drugs; and working with collaborators to formulate and test potential therapies.
In the study of glaucoma, the Das Lab has developed methods to make human optic nerve cells in a Petri dish, and discovered that cleaning up damaged mitochondria by lysosomes is essential for human optic nerve survival.
The lab is investigating medicines required to protect human optic nerve using patient derived cells.
The Imanishi Lab solved several critical questions regarding the mechanisms of maintaining healthy retina and vision, elevating the understanding, treatment and diagnosis of blinding diseases. He developed new technologies to study the renewal of proteins and light-sensitive structures in the eye. He invented a new method for drug discovery.
Research in the Mao Lab focuses on glaucoma and retinal ganglion cells patients lose that transmit visual signal from the eye to the brain. The research team found that cell signaling changes elevate high eye pressure, which kills retinal ganglion cells and causes glaucoma. Currently, the lab working on understand the role of the Wnt signaling pathway in the trabecular meshwork tissue.
The Pattabiraman Lab is studying the molecular mechanisms involved in achieving a normalcy in intraocular pressure as a cure for glaucoma and understanding what goes wrong to cause increased ocular pressure that causes glaucoma. Researchers also study the racial disparity in the preponderance of glaucoma in African Americans compared to Caucasian population.
The Sharma Lab utilized human stem cells to develop different neuronal subtypes and have a patented pressure model for studying various diseases including glaucoma and eye defects in astronauts. The Sharma Lab is currently funded by the Translational Research Institute for Space Health for understanding ocular defects in astronauts.