Dr. Padmanabhan Pattabiraman obtained his Bachelors and Masters majoring in Biochemistry from Tamil Nadu, India and his Ph.D. in Neuroscience from the International School for Advanced Studies (SISSA), Trieste, Italy. He studied the role of neurotrophic factors - brain derived neurotrophic factor and neurotrophin 4/5 - in visual cortical plasticity.
For more information, visit: https://ppattabi.wixsite.com/padhulab
During the post-doctoral training at Duke University in the lab of Dr. Vasanth Rao, he demonstrated the significance of molecular interactions between actomyosin-based contractile activity and extracellular matrix on IOP regulation. His studies provided evidence for the effects of Rho GTPase on mechanotransduction in TM via regulation of ECM synthesis and contractile activity within the AH drainage pathway. He showed this is important in IOP regulation. He generated a rodent model of ocular hypertension by overexpressing constitutively active RhoA. This model provided the proof of concept that constitutively active RhoA induces fibrogenic activity leading to ocular hypertension in a Rho kinase-dependent manner. Inhibition of Rho signaling by Rho kinase inhibitor decreased the IOP via decreasing the ECM deposition. Further, he was involved in the preclinical testing of the RhopressaTM (Netarsudil), currently the first FDA-approved ROCK inhibitor that improves trabecular meshwork outflow from Aerie Pharmaceuticals.
After a brief stint at Case Western Reserve University as a Research Track Investigator, Dr. Pattabiraman joined Glick Eye Institute in Aug 2019 and has a secondary appointment in the Department of Biochemistry and Molecular Biology.
His lab focuses on the following three lines of research:
- Study intraocular pressure regulation in physiological systems (PMID: 34831087)
- Regulation of cytoskeleton and extracellular matrix interactions by proteins and lipids
- Role of extracellular matrix interactions with actin cytoskeleton in intraocular pressure regulation (PMID: 35567755)
- Novel drug discovery and preclinical development of pharmacological as well as molecular therapeutics for lowering intraocular pressure. (PMID: 28609185)
- Preclinical testing of surgical devices for their efficacies in IOP lowering (PMID: 32673594)
Additionally, his lab studies the structural and functional differences in trabecular outflow tissues between people of African (AD) and European Descent (ED). Little knowledge exists of differences in the ECM architecture and compaction in normal and POAG eyes in AD and ED. Dr. Pattabiraman believes that studying the structure of the TM (molecular and cellular) with its function (outflow facility) in non-glaucomatous and glaucomatous donor eyes can identify differences in ocular physiology among AD and ED.
Dr. Avinash Soundararajan - Postdoctoral Fellow - Graduated from Deakin University, Australia in June 2019. 2019 - Present. firstname.lastname@example.org
Ting Wang - Graduate Student (MED NEURO) - 2020 - Present. email@example.com
Anoop Magesh - Research Analyst - 2022 - Present. firstname.lastname@example.org
Lulya Fecadu - LHSI Undergrad Studentship - 2022- Present. email@example.com
Shivendra (Chevy) Singh - Medical Student, IUSM (Former IMPRS student 2020) - 2020- Present - firstname.lastname@example.org
Sai Supriya Vuda - Research Analyst - Sep 2019- May 2021. Currently Med Student at the Univ of Missouri
Sachin Anil Ghag - Research Volunteer - Jan 2020- June 2021. Currently Grad Student at IUB School of Optometry
Wes Stansberry - Rotation Student - March - April 2020
Basant Hens - Rotation Student - March - April 2022
Zion Goldman - LHSI Student - Aug 2021 - May 2022
Anjali Mahes Sivamohan - Summer 2022 - IMPRS Program - Indiana School of Medicine, Evansville
NIH/NEI - R01; CTSI IUSM; 2018 Frank Stein and Paul S May Grant for Innovative Glaucoma Research from The Glaucoma Research Foundation (Shaffer Grant); Eversight Vision Research Grant; CTSC grant from Case Western Reserve University.