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Volunteers sought for IU School of Medicine diabetes research studies


INDIANPOLIS — Indiana University School of Medicine is among a select group of institutions chosen to participate in two National Institutes of Health diabetes research studies.

The studies will evaluate the effects of medications in delaying the onset of or controlling diabetes.

One of seven sites selected for the RISE study — Restoring Insulin Secretion — IU diabetes experts will enroll people at high risk of developing diabetes. The participants will be assigned to one of four randomly assigned treatments that have been approved for use by the U.S. Food and Drug Administration for treatment of diabetes. All study medications will be provided free of charge.

In the other national study, participants enrolling in GRADE, or the Glycemia Reduction Approaches in Diabetes: A Comparative Effectiveness Study, will help evaluate the long-term risks and benefits of four widely used diabetes drugs used in combination with metformin, the most common first-line medication for treating type 2 diabetes.

Participants enrolling in GRADE will take metformin, along with a second medication randomly assigned from among four classes of medications approved for use with metformin by the U.S. Food and Drug Administration. All study medications will be provided free of charge.

For additional information or to enroll in the study at IU, contact the GRADE or RISE study coordinator at 317-274-7679 or