Research

Neurosurgery research at IU School of Medicine encompasses the development of innovative techniques as well as increasing the success of proven treatments.

Whether through clinical and laboratory research projects or involvement in multi-center clinical trials and databases, Department of Neurological Surgery faculty researchers dedicate their life’s work to advancing treatment solutions in this critical area of medicine. 

Neurosurgery Researchers

Faculty Labs

The Gupta Lab

The laboratory of Kunal Gupta, MD, PhD, works to understand the mechanisms responsible for pathological and therapeutic remodeling in the development of epilepsy. Gupta and his team aims to discover novel therapeutic strategies that might prevent the development of epilepsy and recurrence after epilepsy surgery.

Learn more about the Gupta Lab

The Tailor Lab

The laboratory of Jignesh Tailor, MD, PhD, has developed a unique human neural stem cell system to study the role of cancer predisposition gene mutations in brain tumorigenesis. The lab aims to understand how brain tumors are generated in developing human brain so that molecular targets can be identified to prevent tumor formation.

Learn more about the Tailor Lab

The Yadav Lab

In the Brain-Spine-Machine Interfaces Lab led by Amol P. Yadav, PhD, researchers are working to develop neural recording and stimulation tools to treat neurological disorders and understand the brain-spine relationship from a systems neuroscience perspective.

Learn more about the Yadav Lab

Active Clinical Research Investigations

Basic Science Studies

  • Neuromodulatory
    • Wnt modulation in epileptogenesis, neuronal plasticity and the development of epileptic networks. Sponsor: National Institutes of Health: Kunal Gupta, MBBCH, PhD
    • Deep brain stimulation for spasmodic dysphonia: from mechanism to optimal application. Sponsor: CTSI, Collaboration in Translational Research (CTR)/NCATS: Kunal Gupta, MBBCH, PhD
    • RNA sequencing of the whole dentate gyrus in temporal lobe epileptogenesis. Sponsor: CTSI/NIH: Kunal Gupta, MBBCH, PhD
  • Neuro-Oncology
    • Tumor selective retroviral replicating vectors for the treatment of leptomeningeal medulloblastoma. Sponsor: Neurosurgery Research and Education Foundation (NREF): Angela Richardson, MD, PhD
    • Discovery of synthetic lethal targets in MYCN neuroepithelial stem cells. Sponsor: Cure Childhood Cancer, Inc.: Jignesh Tailor, MD, PhD
  • Neurotrauma
    • Role of alterations of mitochondrial lipids in the pathogenesis of spinal cord injury. Sponsor: Indiana State Department of Health, Indiana Spinal Cord and Brain Injury Research (ISDH/ISCBIR): Naikui Liu, MD, MS, PhD
    • A polypharmacological strategy to promote regeneration and recovery of function after cervical spinal cord injury. Sponsor: Indiana State Department of Health, Indiana Spinal Cord and Brain Injury Research (ISDH/ISCBIR): Wei Wu, BMED, PhD
    • Combination of locomotor training and Schwann cell transplantation to promote the micturition function after contusive spinal cord injury. Sponsor: Indiana State Department of Health, Indiana Spinal Cord and Brain Injury Research (ISDH/ISCBIR): Lingxiao Deng, BMED, PhD, MS
    • A novel enzymatic mechanism for removing neurotoxic aldehydes after rodent spinal cord injury. Sponsor: Purdue University (subcontract) NIH/NINDS R21: Xiao-Ming Xu, MD, PhD
    • Modulation of lumbar motor circuitry after an above-level SCI and NT-3 gene therapy. Sponsor: NIH-NINDS R01: Xiao-Ming Xu, MD, PhD
    • Role of FHFs in chronic neuropathic pain following SCI. Sponsor: Craig H. Neilsen Foundation: Naikui Lui, MD, MS, PhD
    • Targeting Multiple Kinases to Treat Experimental Spinal Cord Injury. Sponsor: University of Miami (subcontract) NIH/NINDS R01: Xiao-Ming Xu, MD, PhD
    • Reprogramming reactive glial cells into functional new neurons after SCI. Sponsor: NIH/NINDS R01: Xiao-Ming Xu, MD, PhD
    • Preclinical Development of Human Peripheral Nerve-Derived Therapeutic Products. Sponsor: Indiana State Department of Health, Indiana Spinal Cord and Brain Injury Research (ISDH/ISCBIR): Lingxio Deng, BMED, PhD, MS
    • Improving the functional outcomes by preventing progressive spine loss after repetitive mild traumatic brain injury. Sponsor: Indiana State Department of Health, Indiana Spinal Cord and Brain Injury Research (ISDH/ISCBIR): Xiang Gao, PhD
  • Neurovascular
    Combine intravascular imaging and inverse biomechanical modeling as a novel risk stratification tool for brain aneurysms. Sponsor: University of Oklahoma (subaward American Heart Association): Bradley Bohnstedt, MD