Research

• PENS: A Placebo-Controlled Effectiveness in iNPH Shunting. Condition: Hydrocephalus. Principal Investigator: Jesse Savage, MD

• Bioengineering Strategies to Investigate Treatment Failure in Hydrocephalus. Principal Investigator: Rabia Qaiser, MD
• HCRN: Hydrocephalus Clinical Research Network (HCRN) Core Data Project: Characterizing Patient Populations within the HCRN. Principal Investigator: Jignesh Tailor, MD
• Role of Inflammatory Mediators in Congenital Hydrocephalus. Principal Investigator: Jignesh Tailor, MD

Division of Pediatric Neurological Surgery

• MRgLITT: MRI-Guided Laser Interstitial Thermal Therapy (MRgLITT) Registry. Condition: Epilepsy. Principal Investigator: Jignesh Tailor, MD
• Predicting Seizure Responsiveness to Neuromodulation Using Connectomic Profiling [Vagus Nerve Stimulated (VNS) Study]. Condition: Epilepsy. Principal Investigator: Jignesh Tailor, MD
• Dissecting the cellular heterogeneity of epileptogenic zones. Condition: Epilepsy. Principal Investigator: Jignesh Tailor, MD

• sTaRT: A Multicenter Observational Study of GammaTile™ Surgically Targeted RadiationTherapy (STaRT) in Intracranial Brain Neoplasms. Principal Investigator: Mitesh Shah, MD
• A Phase 3 Randomized Controlled Trial of Post-Surgical Stereotactic Radiotherapy (SRT) versus Surgically Targeted Radiation Therapy (STaRT) with Gamma Tile for Treatment of Newly Diagnosed Metastatic Brain Tumors. Principal Investigator: Mitesh Shah, MD
• Feasibility Study of Resection and GammaTile^® Followed by Concomitant External Beam Radiation Therapy (EBRT) and Temozolomide (TMZ) and Adjuvant TMZ in Newly Diagnosed Glioblastoma (GBM). Principal Investigator:  Mitesh Shah, MD
• An Observational Study: Surgeon experience using the Novel Pulse Control Setting on Sonopet including video demonstration of use. Principal Investigator: Mitesh Shah, MD

• Track TBI/ISTAT: Clinical Evaluation of the i-STAT TBI Test. Condition: Traumatic Brain Injury. Principal Investigator: Shelly Timmons, MD

• EVOLVE: Endovascular Treatment Of Wide-Neck Aneurysms, an Evaluation of Safety, and Effectiveness of Stryker Surpass Evolve Flow Diverter System. Principal Investigator: Bradley Bohnstedt, MD
• INSIGHT: Investigation of Clot in Ischemic Stroke and Hematoma Evacuation. Principal Investigator: Bradley Bohnstedt, MD 
• SEGA: Sedation v. General Anesthesia for Endovascular Therapy in Acute Ischemic Stroke---a randomized comparative effectiveness trial. Principal Investigator: Bradley Bohnstedt, MD
• SURF: A Prospective, Multicenter Study Assessing the Embolization of Neurovascular lesions using WAVE™ Extra Soft coils. Condition is brain aneurysm. Principal Investigator: Bradley Bohnstedt, MD
• RAGE: Ruptured Aneurysms Treated with Hydrogel Coils. Ruptured Brain aneurysm. Principal Investigator: Bradley Bohnstedt, MD
• SUCCESS: Success in Comaneci-assist Coils Embolization Surveillance Study. Condition: wide-necked ruptured and/or unruptured intracranial aneurysms. Principal Investigator: Bradley Bohnstedt, MD
• CITADEL: The Citadel Embolization Device Study. Condition: Brain aneurysm. Principal Investigator: Bradley Bohnstedt, MD

• The Park-Reeves Syringomyelia Research Consortium. Principal Investigator: Laurie Ackerman, MD
• The Genetics of Chiari Malformations. Principal Investigator: Laurie Ackerman, MD

• Wnt modulation in epileptogenesis, neuronal plasticity and the development of epileptic networks. Sponsor: National Institutes of Health: Kunal Gupta, MBBCH, PhD
• Deep brain stimulation for spasmodic dysphonia: from mechanism to optimal application. Sponsor: CTSI, Collaboration in Translational Research (CTR)/NCATS: Kunal Gupta, MBBCH, PhD
• RNA sequencing of the whole dentate gyrus in temporal lobe epileptogenesis. Sponsor: CTSI/NIH: Kunal Gupta, MBBCH, PhD

• Tumor selective retroviral replicating vectors for the treatment of leptomeningeal medulloblastoma. Sponsor: Neurosurgery Research and Education Foundation (NREF): Angela Richardson, MD, PhD
• Discovery of synthetic lethal targets in MYCN neuroepithelial stem cells. Sponsor: Cure Childhood Cancer, Inc.: Jignesh Tailor, MD, PhD

• Role of alterations of mitochondrial lipids in the pathogenesis of spinal cord injury. Sponsor: Indiana State Department of Health, Indiana Spinal Cord and Brain Injury Research (ISDH/ISCBIR): Naikui Liu, MD, MS, PhD
• A polypharmacological strategy to promote regeneration and recovery of function after cervical spinal cord injury. Sponsor: Indiana State Department of Health, Indiana Spinal Cord and Brain Injury Research (ISDH/ISCBIR): Wei Wu, BMED, PhD
• Combination of locomotor training and Schwann cell transplantation to promote the micturition function after contusive spinal cord injury. Sponsor: Indiana State Department of Health, Indiana Spinal Cord and Brain Injury Research (ISDH/ISCBIR): Lingxiao Deng, BMED, PhD, MS
• A novel enzymatic mechanism for removing neurotoxic aldehydes after rodent spinal cord injury. Sponsor: Purdue University (subcontract) NIH/NINDS R21: Xiao-Ming Xu, MD, PhD
• Modulation of lumbar motor circuitry after an above-level SCI and NT-3 gene therapy. Sponsor: NIH-NINDS R01: Xiao-Ming Xu, MD, PhD
• Role of FHFs in chronic neuropathic pain following SCI. Sponsor: Craig H. Neilsen Foundation: Naikui Lui, MD, MS, PhD
• Targeting Multiple Kinases to Treat Experimental Spinal Cord Injury. Sponsor: University of Miami (subcontract) NIH/NINDS R01: Xiao-Ming Xu, MD, PhD
• Reprogramming reactive glial cells into functional new neurons after SCI. Sponsor: NIH/NINDS R01: Xiao-Ming Xu, MD, PhD
• Preclinical Development of Human Peripheral Nerve-Derived Therapeutic Products. Sponsor: Indiana State Department of Health, Indiana Spinal Cord and Brain Injury Research (ISDH/ISCBIR): Lingxio Deng, BMED, PhD, MS
• Improving the functional outcomes by preventing progressive spine loss after repetitive mild traumatic brain injury. Sponsor: Indiana State Department of Health, Indiana Spinal Cord and Brain Injury Research (ISDH/ISCBIR): Xiang Gao, PhD