Below you will find articles and research published in various journals and books during 2022 by faculty in the Department of Pathology and Laboratory Medicine. Bolded text infers primary faculty author as well as residents and/or fellows who worked with our faculty.
Katrina Collins, MD
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Toklu A, Mesa H, Collins K. Incidental adrenal hemangioma clinically suspicious for malignancy: diagnostic considerations and review of the literature. Int J Clin Exp Pathol. 2022;15(11):444-458. Bahler CD, Green MA, Tann MA, Swensson JK, Collins K, Alexoff D, Kung H, Brocken E, Mathias CJ, Cheng L, Hutchins GD, Koch MO. Assessing extra-prostatic extension for surgical guidance in prostate cancer: Comparing two PSMA-PET tracers with the standard-of-care. Urol Oncol. 2023 Jan;41(1):48.e1-48.e9. doi: 10.1016/j.urolonc.2022.10.003. Epub 2022 Nov 1. PMID: 36333187. Miller CQ, Saeed OAM, Collins K. Gastrointestinal histoplasmosis complicating pediatric Crohn disease: A case report and review of literature. World J Gastrointest Endosc 2022; 14(10): 648-656 PMID: 36303809 DOI: 10.4253/wjge.v14.i10.648
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Jessica Davis, MD
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Cho F‡, Odinstov I, Davis L, Christopher CL, Stork L, Somwar R, Ladanyi M, Davis JL, Davare MA. Functional impact and targetability of PI3KCA, GNAS, and PTEN mutations in a spindle cell rhabdomyosarcoma with MYOD1 L122R mutation. Cold Spring Harbor Molecular Case Studies. 2022. Jan;8(1). PMID: 35012940. Baranov E‡, Davis JL, Winsnes K, Church A, Breen M, Janeway KA, Dubois S, Al-Ibraheemi A. Histologic characterization of targeted therapy-treated pediatric mesenchymal neoplasms with kinase alterations. Histopath. 2022; 81: 215-227. PMID: 35543076. Calco GN‡, Davis JL, Chung J. Non-sebaceous lymphadenoma arising as a painless subcutaneous nodule on the eyebrow. JCP. 2022. Epub. PMID: 35717609. Aru M‡, Davis JL, Mills MK, Stacy GS, Grossmann AH, Nomura E, McCallum R, Hansford BG. Beyond schwannomas and neurofibromas: a radiological and histopathological review of lesser-known lesions that arise in association with peripheral nerves. Skeletal Radiology. 2022. Epub. PMID: 36280619 Surrey L,*Davis JL*. NTRK rearranged soft tissue neoplasms: A review of evolving diagnostic entities and algorithmic detection methods. Cancer Genetics. 2022; 260-261: 6-13. PMID: 34794069*Authors contributed equally Davis JL , Al-Ibraaheemi A*, Rudzinski ER*, Surrey L*. Mesenchymal neoplasms with NTRK and other receptor kinase gene alterations (JLD invited review article). Histopathology. 2022 Jan;80(1):4-18.*Authors contributed equally PMID: 34958503  Mau B‡, Hakar M, Lin H, Davis JL. A review of histopathologic features of pediatric autoimmune liver disease. Clinical Liver Disease. 2022. Jul 16;20(4):116-119. PMID: 36245682  |
Hong Du, PhD
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Grabowski, G. A. and Du, H.: Lysosomal Acid Lipase: Roles in Rare Deficiency Diseases, Myeloid Cell Biology, Innate Immunity, and Common Neutral Lipid Diseases. In: CHOLESTEROL: FROM BIOPHYSICS TO THE CLINICS. Chapter 26. 2021. Bukiya, A., Dopico, A., eds., Elsevier, Cambridge, MA
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Michael Feldman, MD, PhD
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1. Adam A Kraya, Kara N Maxwell, Monika A Eiva, Bradley Wubbenhorst, John Pluta , Michael Feldman, Anupma Nayak, Daniel J Powell Jr, Susan M Domchek, Robert H Vonderheide, Katherine L Nathanson: PTEN Loss and BRCA1 Promoter Hypermethylation Negatively Predict for Immunogenicity in BRCA-Deficient Ovarian Cancer. JCO Precis Oncol Feb 2022. PMID: 35201851 2. Kofi K Acheampong, Dylan L Schaff, Benjamin L Emert, Jonathan Lake, Sam Reffsin, Emily K Shea, Courtney E Comar, Leslie A Litzky, Nigar A Khurram, Rebecca L Linn, Michael Feldman, Susan R Weiss, Kathleen T Montone, Sara Cherry, Sydney M Shaffer: Subcellular Detection of SARS-CoV-2 RNA in Human Tissue Reveals Distinct Localization in Alveolar Type 2 Pneumocytes and Alveolar Macrophages. mBio 13(1), Feb 2022. PMID: 35130722 3. Maria Fasolino, Gregory W Schwartz, Abhijeet R Patil, Aanchal Mongia, Maria L Golson, Yue J Wang, Ashleigh Morgan, Chengyang Liu, Jonathan Schug, Jinping Liu, Minghui Wu, Daniel Traum, Ayano Kondo, Catherine L May, Naomi Goldman, Wenliang Wang, Michael Feldman, Jason H Moore, Alberto S Japp, Michael R Betts, HPAP Consortium; Robert B Faryabi, Ali Naji, Klaus H Kaestner, Golnaz Vahedi: Single-cell multi-omics analysis of human pancreatic islets reveals novel cellular states in type 1 diabetes. Nat Metab 4(2): 284-299, Feb 2022. PMID: 35228745/ 4. Oindrila Paul, Jian Qin Tao, Eric West, Leslie Litzky, Michael Feldman, Kathleen Montone, Chamith Rajapakse, Christian Bermudez, Shampa Chatterjee: Pulmonary vascular inflammation with fatal coronavirus disease 2019 (COVID-19): possible role for the NLRP3 inflammasome. Respir Res 23(1): 25, Feb 2022. PMID: 35144622 5. Eliot G Peyster, Andrew Janowczyk, Abigail Swamidoss, Samhith Kethireddy, Michael D Feldman, Kenneth B Margulies: Computational Analysis of Routine Biopsies Improves Diagnosis and Prediction of Cardiac Allograft Vasculopathy. Circulation 145(21), May 2022. PMID: 35405081 6. Xiangxue Wang, Cristian Barrera, Kaustav Bera, Vidya Sankar Viswanathan, Sepideh Azarianpour-Esfahani, Can Koyuncu, Priya Velu, Michael D Feldman, Michael Yang, Pingfu Fu, Kurt A Schalper, Haider Mahdi, Cheng Lu, Vamsidhar Velcheti, Anant Madabhushi: Spatial interplay patterns of cancer nuclei and tumor-infiltrating lymphocytes (TILs) predict clinical benefit for immune checkpoint inhibitors. Sci Adv 8(22), Jun 2022. 7. Jianhong Cheng, John Sollee, Celina Hsieh, Hailin Yue, Nicholas Vandal, Justin Shanahan, Ji Whae Choi, Thi My Linh Tran, Kasey Halsey, Franklin Iheanacho, James Warren, Abdullah Ahmed, Carsten Eickhoff, Michael Feldman, Eduardo Mortani Barbosa Jr, Ihab Kamel, Cheng Ting Lin, Thomas Yi, Terrance Healey, Paul Zhang, Jing Wu, Michael Atalay, Harrison X Bai, Zhicheng Jiao, Jianxin Wang: COVID-19 mortality prediction in the intensive care unit with deep learning based on longitudinal chest X-rays and clinical data. Eur Radiol 32(7): 4446-4456, Jul 2022. PMID: 35184218 8. Clifford W Sandlin, Song Gu, Jun Xu, Charuhas Deshpande, Michael D Feldman, Matthew C Good: Epithelial cell size dysregulation in human lung adenocarcinoma. PLoS One 17(10): e0274091, Oct 2022. PMID: 36201559 9. Anurag Verma, Scott M Damrauer, Nawar Naseer, JoEllen Weaver, Colleen M Kripke, Lindsay Guare, Giorgio Sirugo, Rachel L Kember, Theodore G Drivas, Scott M Dudek, Yuki Bradford, Anastasia Lucas, Renae Judy, Shefali S Verma, Emma Meagher, Katherine L Nathanson, Michael Feldman, Marylyn D Ritchie, Daniel J Rader: The Penn Medicine BioBank: Towards a Genomics-Enabled Learning Healthcare System to Accelerate Precision Medicine in a Diverse Population. J Pers Med 12(12): 1974, Nov 2022. PMID: 36556195 10. Igor Makhlin, Nicholas P McAndrew, E Paul Wileyto, Amy S Clark, Robin Holmes, Lisa N Bottalico, Clementina Mesaros, Ian A Blair, Grace R Jeschke, Kevin R Fox, Susan M Domchek, Jennifer M Matro, Angela R Bradbury, Michael D Feldman, Elizabeth O Hexner, Jacqueline F Bromberg, Angela DeMichele: Ruxolitinib and exemestane for estrogen receptor positive, aromatase inhibitor resistant advanced breast cancer. NPJ Breast Cancer 8(2): 122, Nov 2022. PMID: 36369506 11. Jennifer B Shah, Dana Pueschl, Bradley Wubbenhorst, Mengyao Fan, John Pluta, Kurt D'Andrea, Anna P Hubert, Jake S Shilan, Wenting Zhou, Adam A Kraya, Alba Llop Guevara, Catherine Ruan, Violeta Serra, Judith Balmaña, Michael Feldman, Pat J Morin, Anupma Nayak, Kara N Maxwell, Susan M Domchek, Katherine L Nathanson: Analysis of matched primary and recurrent BRCA1/2 mutation-associated tumors identifies recurrence-specific drivers. Nat Comm 13(1): 6728, Nov 2022. 12. Kelsey S Lau-Min, Danielle McKenna, Stephanie Byers Asher, Tanya Bardakjian, Colin Wollack, Joseph Bleznuck, Daniel Biros, Arravinth Anantharajah, Dana F Clark, Courtney Condit, Jessica E Ebrahimzadeh 1, Jessica M Long, Jacquelyn Powers, Anna Raper, Anna Schoenbaum, Michael Feldman, Lauren Steinfeld, Sony Tuteja, Christine VanZandbergen, Susan M Domchek, Marylyn D Ritchie, Jeffrey Landgraf, Jessica Chen, Katherine L Nathanson: Impact of integrating genomic data into the electronic health record on genetics care delivery. Genet Med 24(11): 2338-50, Nov 2022. 13. Mariana Cooke, Xuyao Zhang, Suli Zhang, Evgeniy Eruslanov, Priti Lal, Reba E Daniel, Michael D Feldman, Martin C Abba, Marcelo G Kazanietz: PROTEIN KINASE C ALPHA IS A CENTRAL NODE FOR TUMORIGENIC TRANSCRIPTIONAL NETWORKS IN HUMAN PROSTATE CANCER. Cancer Res Commun 2(11): 1372-87, Nov 2022. PMID: 36818489 14. Marie Osdoit, Christina Yau, W Fraser Symmans, Judy C Boughey, Cheryl A Ewing, Ron Balassanian, Yunn-Yi Chen, Gregor Krings, Anne M Wallace, Somaye Zare, Oluwole Fadare, Rachael Lancaster, Shi Wei, Constantine V Godellas, Ping Tang, Todd M Tuttle, Molly Klein, Sunati Sahoo, Tina J Hieken, Jodi M Carter, Beiyun Chen, Gretchen Ahrendt, Julia Tchou, Michael Feldman, Eleni Tousimis, Jay Zeck, Nora Jaskowiak, Husain Sattar, Arpana M Naik, Marie Catherine Lee, Marilin Rosa, Laila Khazai, Mara H Rendi, Julie E Lang, Janice Lu, Ossama Tawfik, Smita M Asare, Laura J Esserman, Rita A Mukhtar: Association of Residual Ductal Carcinoma In Situ With Breast Cancer Recurrence in the Neoadjuvant I-SPY2 Trial. JAMA Surg 157(11): 1034-41, Nov 2022. PMID: 36069821 |
Ivan Gonzalez, MD
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González IA, Jain D. Diagnosis and Classification of Vascular Liver Disorders. Diagnostic Histopathology 2022. González IA, Surrey L, Russo P. Hepatocellular adenoma in an infant with Burn-McKeown syndrome: report of a case. Pediatric and Developmental Pathology 2022. PMID: 36262073 [online ahead of print] González IA, Linn RL, Wilkins BJ. Solid-tubulocystic variant of intrahepatic cholangiocarcinoma: report of a pediatric case with molecular characterization. Pediatric and Developmental Pathology 2022. PMID: 36031872 [online ahead of print] Wang D, González IA, Russo P, Jain D, Zhang X. Prominent Pseudoacini in Focal Nodular Hyperplasia: A Potential Diagnostic Pitfall. American Journal of Surgical Pathology 2022;46(10):1380-1385. PMID: 35749760 Farooq A, González IA, Byrnes K, Jenkins S, Hartley C, Hagen C. Multi-institutional development and validation of a novel histologic grading system for colonic graft-versus-host disease. Modern Pathology 2022;35(9):1254-1261. PMID: 35365769 González IA, Stewart DR, Schultz KA, Field AP, Hill DA, Dehner LP. DICER1 Tumor Predisposition Syndrome: An Evolving Story Initiated With The Pleuropulmonary Blastoma. Modern Pathology 2022;35(1):4-22. PMID: 34599283 [Cover of the January 2022 issue and elected as Monthly reader’s choice] González IA, Fuller LD, Zhang X, Papke Jr DJ, Zhao L, Zhang D, Liao X, Liu X, Fiel MI, Zhang X. Development of a scoring system to differentiate amiodarone-induced liver injury from alcoholic steatohepatitis. American Journal of Clinical Pathology 2022;157(3):434-442 PMID: 34596220 |
Jingmei Lin, MD, PhD
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Wang GY, Garcia V, Lee J, Yanum J, Lin J, Jiang H, Dai G. Nrf2 deficiency causes hepatocyte dedifferentiation and reduced albumin production in an experimental extrahepatic cholestasis model. PLoS One. 2022 13;17(6):e0269383. doi: 10.1371/journal.pone.0269383. Lee J, Garcia V, Nambiar SM, Jiang H, Lin J, and Dai G. Activation of proneuronal transcription factor Ascl1 in maternal liver ensures a healthy pregnancy. Cell Mol Gastroenterol Hepatol. 2022; 13(1):33-35. Lee CJ, Vemulapalli KC, Lin J, Rex DK. Metastatic cancer of apparent colon origin with no intraluminal cancer after resection of colorectal lateral spreading lesions. ACG Case Rep J. 2021 Dec 28;9(1):e00716. doi: 10.14309/crj.0000000000000716. eCollection 2022 Jan. PMID: 34977261 Mihaylov P, Lutz AJ, Oppliger F, Lin J. Adenovirus-related fulminant liver failure after kidney transplantation. American J of case reports. 2022; 23:e936564 :: DOI: 10.12659/AJCR.936564. Weldemichael W, Zhang D, Lin J. Histopathological evaluation of recurrent primary biliary cholangitis after liver transplantation. 2022, J of Clinical and Translational Pathol 2(3): 91-99. Everted diverticula with endoscopic mucosal changes mimicking serrated lesions (with video). Rex D, Lahr RE, Lin J. Gastrointestinal Endoscopy. 2022; https://doi.org/10.1016/j.gie.2022.09.001 Saeed O, Panarelli N, Umrau K, Lee HJ, Westerhoff M, Cheng J, and Lin J. The histopathologic features of sickle cell hepatopathy: a multi-institutional study. Am J Clin Pathol. 2022;157(1):73-81. PMID: 34609512 |
Hector Mesa, PhD, MD
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Miller Q, Saeed O. Mesa H. Clinical, Pathologic and Molecular–Genetic Aspects of Colorectal Polyps. Gastrointest. Endosc. Clin. N. 2022; 32(2): 313-328. PMID: 35361338. Khan J, Ullah A, Waheed A, Karki NR, Adhikari N, Vemavarapu L, Belakhlef S, Bendjemil SM, Mehdizadehseraj S, Sidhwa F, Ghleilib I, Foroutan S, Blakely AM, Del Rivero J, Karim NA, Vail E, Heneidi S, Mesa H. Gastrointestinal Stromal Tumors (GIST): A Population-Based Study using the SEER Database, Including Management and Recent Advances in Targeted Therapy. Cancers 2022,14, 3689. https://doi.org/10.3390/cancers14153689. PMID: 35954353. Miller, Q., Dave, N., Popnikolov, N, Bruce SD, Mesa H. Prominent Pseudo-Angiovascular invasion by benign gallbladder epithelium and bile emboli in a patient with delayed cholecystectomy due to COVID-19 positive test. Surg Exp Pathol 2022; 5:18. https://doi.org/10.1186/s42047-022-00120-y. Ullah A, Khan J, Waheed A, Sharma N, Pryor EK, Stumpe TR, Velaquez Zarate L, Cason FD, Kumar S, Misra S, Kavuri S, Mesa H, Roper N, Foroutan S, Karki NR, Del Rivero J, Simonds WF, Abdel Karim N. Parathyroid Carcinoma: Incidence, Survival Analysis, and 2 Management: A Study from the SEER Database and Insights 3 into Future Therapeutic Perspectives. Cancers 2022, 14, 1426. https://doi.org/10.3390/cancers14061426. PMID: 35326576. Puello B, Hwang M, Mesa H, Collins K. Differential Diagnosis of Cystic Lesions of the Spleen: A Review of Clinical, Imaging and Pathological Findings. Int J Surg Path. 2022; DOI: 10.1177/10668969221107080. PMID: 35818747. *†Priemer DS, Wysozan T, Zahedi1 F, Alrabadi N, Mesa H, Vortmeyer AO. Qualitative Comparison of Cryostat- vs. Snap-frozen Neurosurgical Intraoperative Consultations. Int J Surg Path. 2022 doi:10.1177/10668969221117987. PMID: 35971290. Shabaan A, Alkashash A, Hou T, Saeed O, Yesensky J, Roshal A, Mesa H. Isolated Kaposi sarcoma of the upper aerodigestive tract in immunocompetent individuals, an underrecognized entity with favorable prognosis. Ear Nose Throat J 2022 DOI: 10.1177/01455613221128112. Jones KJ, Dougherty RE, Randolph M, Sim MW, Mesa H. Cobas® HPV Genotyping of FNA-Sample-Supernatant and Frozen-Section- Scrapings of Suspected Head and Neck Cancer. AIMM 2022. doi: 10.1097/PAI.0000000000001066. PMID: 36121288.
Journal articles accepted in 2022, not yet printed: |
Mehdi Nassiri, MD
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Gulati R, Abu-Salah A, Salous T, Nassiri M. Relapse of Tagraxofusp treated Blastic Plasmacytoid Dendritic Cell Neoplasm with Loss of CD123 Expression. Journal of Hematopathology. 2022 15:35-39. doi.org/10.1007/s12308-021-00479-z Al-Obaidy KI, Saleeb RM, Trpkov K, Williamson S, Sangoi A, Hes O, Montironi R, Cimadamore A, Acosta AM, Nassiri, M, Alruwaii, Z; Alkashash A, Hassan O, Gupta N, Sakr WA, Osunkoya AO, Sen JD, Baldrige LA, Idrees MT, Eble JN, Grignon DJ, Cheng L, Recurrent KRAS Mutations are Early Events in the Development of Papillary Renal Neoplasm with Reverse Polarity: An International Multi-Institutional Analysis of 50 Neoplasms. Modern Pathology. 2022 Sep;35(9):1279-1286. doi: 10.1038/s41379-022-01018-6, PMID: 35152262 Nassiri M. Interoperability, how far and how well will your data travel? Medical Laboratory Observer. 2022 Feb Vol 54 N0.2 p26-29, https://www.mlo-online.com/information-technology/lis/article/21253050/how-far-and-how-well-will-your-data-travel. Saxena R, Nassiri M, Yin XM, Morral N. Insights from a high-fat diet fed mouse model with a humanized liver. PLOS ONE. 2022 May 9;17(5):e0268260. doi: 10.1371/journal.pone.0268260. eCollection 2022. PMID: 35533183 Zhou J, Nassiri M. Lymphoproliferative neoplasms with plasmablastic morphology: an overview and diagnostic approach. Archives of Pathology and Laboratory Medicine. 2022 Apr 1;146(4):407-414. doi: 10.5858/arpa.2021-0117-RA. PMID: 34559873 Araujo de Oliveira Santana M, Butt S, Nassiri M. Central nervous system Whipple disease presenting as hypersomnolence. Cureus. 2022 14(3): e23572. doi:10.7759/cureus.23572. PMID: 35494928 |
Ryan Relich, PhD
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In-print, PubMed-indexed journal articles published in 2022: 1. Syndromic and Point-of-Care Molecular Testing - PubMed (nih.gov) 2. Cepheid Xpert Xpress Flu/RSV evaluation performed by minimally trained non-laboratory operators in a CLIA-waived environment - PubMed (nih.gov) 3. Clinical comparison and agreement of PCR, antigen, and viral culture for the diagnosis of COVID-19: Clinical Agreement Between Diagnostics for COVID19 - PubMed (nih.gov) 4. A 58-Year-old Man With Multifocal Pulmonary Nodules - PubMed (nih.gov) 5. Erratum for Pancholi et al., "Multicenter Evaluation of the Simplexa VZV Direct Assay for Detection of Varicella-Zoster Virus in Cerebrospinal Fluid and Lesion-Swab Specimens" - PubMed (nih.gov) 6. Soluble Immune Checkpoints Are Dysregulated in COVID-19 and Heavy Alcohol Users With HIV Infection - PubMed (nih.gov) 7. Serum from COVID-19 patients early in the pandemic shows limited evidence of cross-neutralization against variants of concern - PubMed (nih.gov) 8. Microbiology of bile aspirates obtained at ERCP in patients with suspected acute cholangitis - PubMed (nih.gov) Published for the American Society for Microbiology, not indexed in PubMed: 1. Mitchell S, Bateman A, Relich R, Munster V, Antonara S, Humphries R, Anderson N, She R, Anglewicz C, Filkins L, Scheutz A. 2022. Monkeypox virus biosafety and testing recommendations. American Society for Microbiology. https://asm.org/Guideline/Monkeypox-Virus-Biosafety-and-Testing-Recommendation. 2. Mitchell S, Bateman A, Relich R, Munster V, Filkins L, Schuetz A. 2022. Monkeypox virus inactivation guidance for nucleic acid testing validation. American Society for Microbiology. https://asm.org/Guideline/Monkeypox-Virus-Inactivation-Guidance-for-Nucleic. Journal articles accepted in 2022, not yet printed: 1. Gavina K, Whitacre B, Meyer T, Van Benten K, Glazier M, Emery C, Lavik JP, Relich RF. 2022. The Brief Case: Suspicious Gram-Negative coccobacilli – Francisella tularensis susp. novicida isolated from an immunocompromised patient with blastomycosis. J Clin Microbiol. ACCEPTED: AUGUST 2022. 2. Gavina K, Whitacre B, Meyer T, Van Benten K, Glazier M, Emery C, Lavik JP, Relich RF. 2022. Closing the Brief Case: Suspicious Gram-Negative coccobacilli – Francisella tularensis susp. novicida isolated from an immunocompromised patient with blastomycosis. J Clin Microbiol. ACCEPTED: AUGUST 2022. 3. Relich RF, Loeffelholz MJ. 2023. Taxonomic changes for human viruses, 2020-2022. J Clin Microbiol. ACCEPTED: SEPTEMBER 2022. |
Omer Saeed, MD
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Miller Q, Saeed O, Collins K: Gastrointestinal histoplasmosis complicating pediatric Crohn disease: a case report and review of the literature. World J Gastrointest Endosc. Oct 16, 2022; 14(10): 648-656 Shabaan A, Alkashash A, Hou T, Saeed O, Yesensky J, Roshal A, Mesa H: Isolated Kaposi sarcoma of the upper aerodigestive tract in immunocompetent individuals, an underrecognized entity with favorable prognosis. Ear, Nose & Throat J. 2022, Vol 0(0) 1-5. Saeed OAM, Armutlu A, Cheng L, Longe HO, Saxena R: Tumor genomic profiling to determine tissue origin of cancers of unknown primary: a single institute experience with its utility and impact on patient management. App Immunohistochem Mol Morphol. 2022 Oct 1;30(9):592-599. Tirkes T, Saeed OA, Osuji VC, Kranz CE, Roth AA, Patel AA, Zyromski NJ, Fogel EL: Histopathologic correlation of pancreatic fibrosis with pancreatic magnetic resonance imaging quantitative metrics and Cambridge classification. Abdom Radiol (NY). 2022 Jul;47(7):2371-2380. Miller Q, Saeed O, Mesa H: Clinical, Pathologic and Molecular-Genetic Aspects of Colorectal Polyps. Gastrointest Endosc Clin N Am. 2022 Apr; 32(2):313-328. Armutlu A, Saeed O, Saxena R, Metastatic liver tumors in surgical pathology: impact of contemporary diagnostic and therapeutic paradigms in a tertiary care center. Int J Surg Pathol 2022 Apr; 30(2): 138-144. Saeed O, Panarelli N, Umrau K, Lee H, Westerhoff M, Cheng J, Lin J: The histopathologic features of sickle cell hepatopathy; a multi-institutional study. Am J Clin Pathol 2022 Jan 6; 157 (1):73-81. Book chapters
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George Sandusky, DVM, PhD
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Tumor collection/processing under physioxia uncovers highly relevant signaling networks and drug sensitivity. Science Advances 1/12/2022 https://www.science.org/doi/full/10.1126/sciadv.abh3375 Aberrant epigenetic and transcriptional events associated with breast cancer risk. Clinical Epigenetics 2/9/2022 FAM83A is a potential biomarker for breast cancer initiation. Biomarker Research. 2/19/2022. https://biomarkerres.biomedcentral.com/articles/10.1186/s40364-022-00353-9 Using VBIM Technique to Discover ARMC4/ODAD2 as a Novel Negative Regulator of NF-κB and a New Tumor Suppressor in Colorectal Cancer. International Journal of Molecular Sciences. 2/27/2022. https://www.mdpi.com/1422-0067/23/5/2732 Exposure to perfluorooctanoic acid leads to promotion of pancreatic cancer. Carcinogenesis. 3/5/2022. https://academic.oup.com/carcin/article/43/5/469/6504004 Polyphenic Risk Score Shows Robust Predictive Ability For Long-Term Future Suicidality. Research Square. 3/17/2022. https://www.researchsquare.com/article/rs-1442969/v1 Cortactin loss protects against hemin-induced acute lung injury in sickle cell disease. American Journal of Physiology. 6/1/2022. https://journals.physiology.org/doi/full/10.1152/ajplung.00274.2021 Metabolic Links to Socioeconomic Stresses Uniquely Affecting Ancestry in Normal Breast Tissue at Risk for Breast Cancer. Frontiers in Oncology. 6/27/2022. https://www.frontiersin.org/articles/10.3389/fonc.2022.876651/full Inhibition of BTK and PI3Kδ impairs the development of human JMML stem and progenitor cells. Molecular Therapy. 7/6/2022. https://www.sciencedirect.com/science/article/pii/S1525001622002386 Influence of genetic ancestry on breast stromal cells provides biologic basis for increased incidence of metaplastic breast cancer in women of African descent. Research Square. 7/27/2022. https://www.researchsquare.com/article/rs-1855615/v1 Inhibition of MEK signaling prevents SARS-CoV2-induced lung damage and improves the survival of infected mice. Journal of Medical Virology. 8/31/2022. https://onlinelibrary.wiley.com/doi/10.1002/jmv.28094 Pathological Lung Lesions of COVID-19 and Opioid Use Disorder: A Post-Mortem Lung and Toxicology Examination of 43 Decedents. Forensic Medicine and Anatomy Research. 10/26/2022. https://www.scirp.org/journal/paperinformation.aspx?paperid=120683 Use of multimodality imaging, histology, and treatment feasibility to characterize a transgenic Rag2-null rat model of glioblastoma. Frontiers in Oncology. 11/22/2022. https://www.frontiersin.org/articles/10.3389/fonc.2022.939260/full Aberrant epigenetic and transcriptional events associated with breast cancer risk. Clinical Epigenetics. 02//09/2022. |
Sheila Segura, MD
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Segura SE, Young RH, Oliva E, Ulbright TM. Malignant Gonadal Germ Cell Tumors (Other Than Pure Germinoma) in Patients With Disorders of Sex Development: A Report of 21 Cases Based Largely on the Collection of Dr Robert E. Scully, Illustrating a High Frequency of Yolk Sac Tumor With Prominent Hepatoid and Glandular Features. Am J Surg Pathol. 2022 May 1;46(5):664-676. |
Gizem Tumer, MD
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Long-Term Outcomes of Kidney Transplant Recipients with Glomerulonephritides by Induction Type and Steroid Avoidance. Prasanth Ravipati, Scott Jackson, Gizem Tumer, Patrick H. Nachman, and Samy M. Riad. Transplantology 2022, 3(1), 68-82; https://doi.org/10.3390/transplantology3010007 Published: 11 February 2022 |
Thomas Ulbright, MD
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Acosta AM, Al-Obaidy KI, Sholl LM, Ulbright TM, Idrees MT: Molecular analysis of adenocarcinomas of the rete testis demonstrates frequent alterations in genes involved in cell cycle regulation. Histopathology 2022, 81:77-83. Acosta AM, McKenney JK, Sholl LM, Dickson BC, Matoso A, Lu H, Jo VY, Collins K, Ulbright TM, Fletcher CDM: Molecular assessment of paratesticular rhabdomyomas demonstrates recurrent findings, including a novel H3C2 p.K37I mutation. Mod Pathol 2022 (Epub ahead of print). Al-Obaidy KI, Idrees MT, Abdulfatah E, Kunju LP, Wu A, Ulbright TM: Large Cell Calcifying Sertoli Cell Tumor: A Clinicopathologic Study of 18 Cases With Comprehensive Review of the Literature and Reappraisal of Prognostic Features. Am J Surg Pathol 2022, 46:688-700. Collins K, Sholl LM, Siegmund S, Dickson BC, Colecchia M, Michalová K, Hwang M, Ulbright TM, Kao CS, van Leenders G, Mehta V, Trpkov K, Yilmaz A, Cimadamore A, Matoso A, Epstein JI, Maclean F, Comperat E, Anderson WJ, Fletcher CDM, Acosta AM: Myoid gonadal stromal tumours are characterised by recurrent chromosome-level copy number gains: molecular assessment of a multi-institutional series. Histopathology 2022. (Epub ahead of print) Collins K, Warmke LM, Chen S, Ulbright TM: Angiomyofibroblastoma and Potential Mimicking Soft Tissue Tumors That May Occasionally Present in the Retroperitoneum: An Approach to the Differential Diagnosis With Report of an Unusual Index Case Abutting the Kidney. Adv Anat Pathol 2022, 29:141-53. Hou T, Levy DR, Ulbright TM: Morphologic Changes in the Thymus Following Chemotherapy for Anterior Mediastinal Germ Cell Tumors. Arch Pathol Lab Med 2022. (Epub ahead of print) Pashankar F, Hanley K, Lockley M, Stoneham S, Nucci MR, Reyes-Múgica M, Elishaev E, Vang R, Veneris J, Rytting H, Olson T, Hazard K, Covens A, Arora R, Billmire D, Al-Ibraheemi A, Ulbright TM, Frazier L, Hirsch MS: Addressing the diagnostic and therapeutic dilemmas of ovarian immature teratoma: Report from a clinicopathologic consensus conference. Eur J Cancer 2022, 173:59-70. Przybycin CG, Williamson SR, Kao CS, Reyes-Múgica M, Ulbright TM, McKenney JK: Nodular maturation of the testis: a Non-neoplastic lesion of boys that may present as a mass on clinical and ultrasound examination. Am J Surg Pathol 2022, 46:220-5. Segura SE, Young RH, Oliva E, Ulbright TM: Malignant Gonadal Germ Cell Tumors (Other Than Pure Germinoma) in Patients With Disorders of Sex Development: A Report of 21 Cases Based Largely on the Collection of Dr Robert E. Scully, Illustrating a High Frequency of Yolk Sac Tumor With Prominent Hepatoid and Glandular Features. Am J Surg Pathol 2022, 46:664-76. Warmke LM, Cheng L, Sperling RM, Sen JD, Ulbright TM: Atypical cartilage in type II germ cell tumors of the mediastinum show significantly different patterns of IDH1/2 mutations from conventional chondrosarcoma. Mod Pathol 2022, 35:1636-43. Wyvekens N, Sholl LM, Yang Y, Tran I, Vasudevaraja V, Dickson BC, Al-Obaidy KI, Baniak N, Collins K, Gordetsky JB, Idrees MT, Kao CS, Maclean F, Matoso A, Ulbright TM, Wobker SE, Fletcher CDM, Hirsch MS, Hornick JL, Snuderl M, Acosta AM: Molecular correlates of male germ cell tumors with overgrowth of components resembling somatic malignancies. Mod Pathol 2022 (Epub ahead of print). Book published in 2022Ulbright TM, Kao C-S, Williamson SR, Idrees MT: Tumors and Tumor-Like Lesions of the Testis and Adjacent Tissues. AFIP Atlases of Tumor and Non-Tumor Pathology. Edited by Hornick JL. Fifth series, Fascicle 12, Arlington, VA: American Registry of Pathology, 2022. |
Ruben Vidal, PhD
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Y. Yang, H. J. Garringer, Y. Shi, S. Lövestam, X. Zhang, A. Kotecha, M. Bacioglu, A. Koto, M. Takao, M. G. Spillantini, B. Ghetti, R. Vidal, A. G. Murzin, S. H.W. Scheres, M. Goedert. New SNCA mutation and structures of α-synuclein filaments from juvenile-onset synucleinopathy. (2022) Acta Neuropathol. (submitted). A. Fernandez, M. T. Gomez, and R. Vidal. Lack of ApoE inhibits ADan amyloidosis in a mouse model of Familial Danish Dementia (2022) J. Biol. Chem. (in press). L. Lantz, H. Shirani, B. Ghetti, R. Vidal, T. Klingstedt, and K. P. R. Nilsson. Thiophene-based ligands for multiplex spectral detection of distinct protein aggregates in tissue sections with Alzheimer’s disease pathology. (2022) ChemBioChem (submitted). Y. Yang, Y. Shi, M. Schweighauser, X. Zhang, A. Kotecha, A. G. Murzin, H. J. Garringer, P. W. Cullinane, Y. Saito, T. Foroud, T. T. Warner, K. Hasegawa, R. Vidal, S. Murayama, T. Revesz, B. Ghetti, M. Hasegawa, T. Lashley, S. H. W. Scheres, and M. Goedert. Cryo-EM structures of α-synuclein filaments from Parkinson’s disease and dementia with Lewy bodies. (2022) Nature Sep 15. doi: 10.1038/s41586-022-05319-3. Online ahead of print. L. Björk, M. Bäck, B. Ghetti, R. Vidal, T. Klingstedt, and K. P. R. Nilsson. Proteophenes - amino acid functionalized thiophene-based fluorescent ligands for visualization of protein deposits in tissue sections with Alzheimer´s disease pathology. (2022) Chemistry 11:e202201557. doi: 10.1002/chem.202201557. L. Cracco, E. H. Doud, G. I. Hallinan, H. J. Garringer, M. H. Jacobsen, R. Richardson, E. Buratti, R. Vidal, B. Ghetti, Kathy L. Newell. Distinguishing post-translational modifications in dominantly inherited FTD: FTLD-TDP Type A (GRN) versus Type B (C9orf72). (2022) Neuropathol. Appl. Neurobiol. 48(6):e12836. doi: 10.1111/nan.12836. G. I. Hallinan, K. A. Ozcan, Md. R. Hoq, L. Cracco, F. S. Vago, S. R. Bharath, D. Li, M. Jacobsen, E. H. Doud, A. L. Mosley, A. Fernandez, H. J. Garringer, W. Jiang*, B. Ghetti*, and R. Vidal*. Cryo-EM structures of Prion protein filaments from Gerstmann-Sträussler-Scheinker disease. (2022) Acta Neuropathol. 144(3):509-520. doi: 10.1007/s00401-022-02461-0 (*Co-last authors). M. Schweighauser, D. Arseni, M. Bacioglu, M. Huang, S. Lövestam, Y. Shi, Y. Yang, W. Zhang, A. Kotecha , H. J. Garringer, R. Vidal, G. I. Hallinan, K. L. Newell, A. Tarutani, S. Murayama, M. Miyazaki, Y. Saito, M. Yoshida, K. Hasegawa, T. Lashley, T. Revesz, G. G. Kovacs, J. van Swieten, M. Takao, M. Hasegawa, B. Ghetti, M. G. Spillantini, B. Ryskeldi-Falcon, A. G. Murzin, M. Goedert, S. H.W. Scheres. Age-dependent formation of TMEM106B amyloid filaments in human brains. (2022) Nature 605(7909):310-314. doi: 10.1038/s41586-022-04650-z. X. Taylor, P. Cisternas, N. Jury, P. Martinez, X. Huang, Y. You, J. Redding-Ochoa, R. Vidal, J. Zhang, J. Troncoso, and C. A. Lasagna-Reeves. Activated Endothelial Cells Induce a Distinct Type of Astrocytic Reactivity. (2022) Commun. Biol. Mar 29;5(1):282. doi: 10.1038/s42003-022-03237-8. Y. Yang, D. Arseni, W. Zhang, M. Huang, S. Lövestam, M. Schweighauser, A. Kotecha, A. G. Murzin, S. Y. Peak-Chew, J. Macdonald, I. Lavenir, H. J. Garringer, E. Gelpi, K. L. Newell, G. G. Kovacs, R. Vidal, B. Ghetti, B. Ryskeldi-Falcon, S.H.W. Scheres, M. Goedert. Cryo-EM structures of amyloid-β 42 filaments from human brain. (2022) Science 375(6577):167-172. doi: 10.1126/science.abm7285. |
Alexander Vortmeyer, PhD, MD
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Kidney in VHL disease: Early clear cell proliferation occurs in the distal tubular system. Nayef S. Al‑Gharaibeh, Constance J. Temm, Sharon B. Shively, and Alexander Vortmeyer. September 22, 2022 DOI: 10.3892/or.2022.8437
Characterization of Microscopic Multicellular Foci in Grossly Normal Renal Parenchyma of Von Hippel-Lindau Kidney. Nayef S. Al‑Gharaibeh, Sharon B. Shively, and Alexander Vortmeyer. Medicina 2022, 58, 1725 Qualitative Comparison of Cryostatversus Snap-Frozen Neurosurgical Intraoperative Consultations. David S. Priemer, MD, Timothy Wysozan, Farhad Zahedi, MD, Nasr Alrabadi, Hector Mesa, MD, PhD, and Alexander O. Vortmeyer, MD, PhD. International Journal of Surgical Pathology 1–8 Developmentally Arrested Basket/Stellate Cells in Postnatal Human Brain as Potential Tumor Cells of Origin for Cerebellar Hemangioblastoma in Von Hippel-Lindau Patients. Sharon Baughman Shively, MD, PhD, Nancy A. Edwards, Tobey J. MacDonald, MD, Kory R. Johnson, PhD, Natalia M. Diaz-Rodriguez, MD, Marsha J. Merrill, PhD, and Alexander O. Vortmeyer, MD, PhD. J Neuropathol Exp Neurol Vol. , No. , , pp. 1–15. https://doi.org/10.1093/jnen/nlac073 |
Simon Warren, MD
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Czaja R, Layng KV, Barrett A, Hooper P, Alomari A, Warren S. An NTRK-1-associated soft tissue tumor showing distinctive nodules with peripheral accentuation of cellularity. J Cutan Pathol. 2022 PMID: 36335562. |
Howard Wu, MD
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Hang JF, Lee JJL, Nga MN, Higuchi K, Hirata Y, Wu HH, Alison DB, Gilbert JD, Lin O, Saieg M, de Arruda AF, Chen YA, Huang EC, Manucha V. Multi-institutional validation of a modified scheme for subcategorizing salivary gland neoplasm of uncertain malignant potential (SUMP). Cancer Cytopathol 2022;130:511-522 Khan, J.; la Sancha, C.D.; Saad, M.; Alkashash, A.; Ullah, A.; Alruwaii, F.; Velasquez Zarate, L.; Cramer, H.M.; Wu, H.H. The Role of Fluorescence In Situ Hybridization in Pancreatobiliary Brushing Cytology: A Large Retrospective Review with Histologic Correlation. Diagnostics 2022, 12, 2486. |
Cong Yan, PhD
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Lysosomal acid lipase, CSF1R, and PD-L1 determine functions of CD11c+ myeloidderived suppressor cells. Ting Zhao, Sheng Liu, Xinchun Ding, Erica M. Johnson, Nasser H. Hanna, Kanhaiya Singh, Chandan K. Sen, Jun Wan, Hong Du, and Cong Yan. JCI Insight. 2022;7(17):e156623. https://doi.org/10.1172/jci.insight.156623. Ting Zhao, Sheng Liu, Xinchun Ding, Erica M. Johnson, Nasser H. Hanna, Kanhaiya Singh, Chandan K Sen, Jun Wan, Hong Du, and Cong Yan: Lysosomal Acid Lipase, CSF1R and PD-L1 Determine Functions of CD11c+ Myeloid-Derived Suppressor Cells (2022). JCI Insight, 2022;7(17):e156623. PMID: 35917184, doi: 10.1172/jci.insight.156623. |
Ting Zhao, PhD, MS
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Title: Lysosomal acid lipase, CSF1R, and PD-L1 determine functions of CD11c+ myeloid-derived suppressor cells. Journal: JCI Insight Date, issue and page: 2022 Sep 8;7(17):e156623. doi: 10.1172/jci.insight.156623. PMID: 35917184 |
Michelle Zimmerman, MD
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Griffin AJ, O'Donnell KL, Shifflett K, Lavik JP, Russell PM, Zimmerman MK, Relich RF, Marzi A. Serum from COVID-19 patients early in the pandemic shows limited evidence of cross-neutralization against variants of concern. Sci Rep. 2022 Mar 10;12(1):3954. doi: 10.1038/s41598-022-07960-4. PMID: 35273264; PMCID: PMC8913826. |