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Clinical Research

The study of emergency medicine is a broad field that covers the variety of ailments arriving at the emergency room, with a deep focus on how to improve particular aspects of urgent care.

Throughout their clinical research initiatives, faculty members of Indiana University School of Medicine’s Department of Emergency Medicine are devoted to developing future leaders and investigators, dedicating funds and considerable resources to continue their successful track record of mentorship. They actively support junior investigators, fellows and residents as well as senior faculty seeking novel lines of inquiry.

Diverse Patient Population

Department researchers actively seek and encourage other investigators toward collaborative studies, both within and outside IU School of Medicine. Among Riley Hospital for Children, Eskenazi and IU Health Methodist hospitals, the patient volume is vast and varied. Opportunities exist to engage patients—for acute studies and as contacts for future research endeavors such as studies, biobanking and registries.

Department investigators have significant experience with various study designs as well as the ability to collect, process and store biologic samples around the clock. Notably, the Department of Emergency Medicine at IU School of Medicine has experience with both federally funded and industry-sponsored trials.

Emergency Medicine investigators treat patients at Indiana University Health hospitals, including Methodist, Riley Hospital for Children (downtown and North), University, Bloomington, North and West as well as at Sidney and Lois Eskenazi Hospital and through Indianapolis Emergency Medical Services (EMS).

Full-Scope Research Leadership

Under the guidance of Director of Clinical Research, Peter Pang, MD, MS, and Vice Chair of Research, Jeffrey Kline, MD, the Emergency Medicine research team encompasses all aspects of clinical research—from regulatory and enrollment to follow up and study completion.

Collaborative partners include the Indiana University Physical Education Department, Health and Hospital Corporation of Marion County, Krannert Institute of Cardiology (IU School of Medicine Cardiology Research division), and IU Health and Rehabilitation Services.

23006-Pang, Peter

Peter S. Pang, MD

Interim Chair, Department of Emergency Medicine

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21891-Kline, Jeffrey

Jeffrey A. Kline, MD

Eskenazi Health Foundation Professor of Emergency Medicine

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Clinical Trials

The Department of Emergency Medicine regularly performs a wide variety clinical trials to study the effectiveness of new therapies. All clinical trials are managed through Indiana University’s Clinical Trials Office, which reviews and approves all contractual documents. Clinical trials in this department study conditions such as venous thromboembolism, heart failure, right ventricle dysfunction, pain, anxiety, suicide, empathy assessment, mild traumatic brain injury, cardiac arrest, atrial fibrillation, residency and Emergency Medical Services (EMS).

BOOST-3 Clinical Trial

BOOST-3 is a research study to learn if either of two strategies for monitoring and treating patients with TBI in the intensive care unit (ICU) is more likely to help them get better. Both of these alternative strategies are used in standard care. It is unknown if one is more effective than the other. In one strategy doctors concentrate only on preventing high ICP (intracranial pressure) caused by a swollen brain. In the other strategy doctors try to prevent high ICP, and also try to prevent low PbtO2 (brain oxygen). It is unknown if measuring and treating low brain oxygen is more effective, less effective, or the same as monitoring and treating high brain pressure alone. The results of this study will help doctors discover if one of these methods is safer and more effective.

ACCESS Clinical Trial

Sudden cardiac arrest occurring outside of the hospital is the third leading cause of death in the United States. IU School of Medicine emergency medicine researchers are part of a national effort to study standard treatment options for a type of cardiac arrest that has the highest survival rate and the greatest opportunity for improved health outcomes.

The ACCESS Trial has been completed in Marion County. The study aimed to determine the best method of care for survival and neurological recovery for patients resuscitated after cardiac arrest due to ventricular fibrillation (VF) outside of the hospital, but who have no evidence of a heart attack on an electrocardiogram (ECG).