TBI

The Wu lab addresses the sensitivity issues of conventional medical imaging techniques in detecting mild traumatic brain injury (mTBI) by utilizing hybrid diffusion imaging (HYDI). By employing advanced diffusion imaging techniques such as neurite orientation dispersion and density imaging (NODDI) and q-space analyses, the study identified significant white matter alterations in patients with mTBI compared to trauma control patients. Furthermore, correlations between diffusion metrics and neuropsychological test results revealed potential biomarkers for mTBI, indicating that NODDI-derived axonal density index and q-space measures could serve as sensitive indicators of white matter changes associated with mTBI.

 

Imaginges of brain scans, TBI

Active Research

Grant: 0255-G861-4609
PI: Kristen Dams-O’Connor and Flora Hammond
2022-25

Grant: R44AG060861
PI: D. Mathews and Yu-Chien Wu
2022-24

Get Research Updates

To stay up-to-date on the medical research work at IU School of Medicine, follow the IU School of Medicine research blog, where investigators throughout the school’s academic departments statewide post updates about their work.

Discover active research areas